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This example shows findings from an assessment of the unique pattern of genomic variations in human leukocyte antigens (HLA) for the purpose of characterizing the alleles, in order to...
understand the immune system (such as... ) to support tissue matching and to characterize/understand/ immune disease.
mechanism of action of drug and
- tissue matching
- immune system assessments
for the the immune system autoimmune
The identification of specific HLA alloantigens is used to select cell, tissue and organ donors [5], [6], [7]; to diagnose autoimmune diseases [8]; to determine the risk of adverse drug reactions [9]; and to guide immunotherapies [10].
This example shows findings from an assessment of genomic variations in drug metabolizing genes with the purpose of determining how variations in those genes affect drug absorption, distribution, metabolism, and excretion (ADME). The method used to summarize nucleotide variation is represented in variable GFANMETH where appropriate. Identifying information for the genomic panel is represented in SPDEVID. Additional information about the genomic panel may be represented in the Medical Device Domains (e.g., DI domain) as needed.
a pattern of genomic variations in human leukocyte antigens (HLA) with the purpose of determining genotyping of
| An assessment of the unique pattern of sequence variation of one to many loci associated with a normal or abnormal biological process. | A characterization or classification of the allele. |
Show the predicted phenotype based on the unique pattern of nucleotide variation of gene CYP2C19 that is involved in ADME.
This example shows findings from an assessment of genomic variations in drug metabolizing genes with the purpose of determining how variations in those genes affect drug absorption, distribution, metabolism, and excretion (ADME). The method used to summarize nucleotide variation is represented in variable GFANMETH where appropriate. Identifying information for the genomic panel is represented in SPDEVID. Additional information about the genomic panel may be represented in the Medical Device Domains (e.g., DI domain) as needed.
Genotyping of the human leucocyte antigen (HLA) is indispensable for transplantation of hematopoietic stem cells or organs [1–3] and for the management of other diseases involving immune reactions [4].
how variations in those genes affect drug absorption, distribution, metabolism, and excretion (ADME).
The method used to summarize nucleotide variation is represented in variable GFANMETH where appropriate. Identifying information for the genomic panel is represented in SPDEVID. Additional information about the genomic panel may be represented in the Medical Device Domains (e.g., DI domain) as needed.
This example shows findings from an assessment of the unique pattern of sequence variation of one to many loci associated
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An assessment of the unique pattern of sequence variation of one to many loci associated with a normal or abnormal biological process.
Human leukocyte antigen (HLA) typing
This example shows findings from an assessment of genomic variations in genes associated with HLA typing with the purpose of determining the allele subtypes.
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