This example shows PK parameters calculated from time-concentration profiles for the parent drug and 1 metabolite in plasma and urine for one subject. Note that PPRFTDTC is populated in order to link the PP records to the respective PC records. In this example, PPSPEC is null for observed total clearance (PPTESTCD = "CLO") records because it is calculated from multiple specimen sources (i.e., plasma and urine).
Rows 1-12:
Show parameters for day 1.
Rows 13-24:
Show parameters for day 4
pp.xpt
pp.xpt
Row
STUDYID
DOMAIN
USUBJID
PPSEQ
PPGRPID
PPTESTCD
PPTEST
PPCAT
PPORRES
PPORRESU
PPSTRESC
PPSTRESN
PPSTRESU
PPSPEC
PPANMETH
VISITNUM
VISIT
PPDTC
PPRFTDTC
PPSTINT
PPENINT
1
ABC-123
PP
123-0001
1
DAY1_PAR
TMAX
Time of CMAX
NICOTINE PARENT
5
m
5
5
m
PLASMA
non-compartmental analysis. and corrected for baseline
1
DAY 1
2002-01-07
2001-02-01T08:00
2
ABC-123
PP
123-0001
2
DAY1_PAR
CMAX
Max Conc
NICOTINE PARENT
13
ng/mL
13
13
ng/mL
PLASMA
non-compartmental analysis. and corrected for baseline
1
DAY 1
2002-01-07
2001-02-01T08:00
3
ABC-123
PP
123-0001
3
DAY1_PAR
AUCALL
AUC All
NICOTINE PARENT
11.4
h*ng/mL
11.4
11.4
h*ng/mL
PLASMA
non-compartmental analysis. and corrected for baseline
1
DAY 1
2002-01-07
2001-02-01T08:00
3
ABC-123
PP
123-0001
3
DAY1_PAR
AUCINT
AUC from T1 to T2
NICOTINE PARENT
6.0
h*ng/mL
6.0
6.0
h*ng/mL
PLASMA
non-compartmental analysis. and corrected for baseline