Nonclinical studies are conducted in tobacco product research to demonstrate
- biological activity within biological systems and identify toxicity and genotoxicity related to the products.
To see what kind of toxicity is related to the products
Understanding how tobacco products and changes to tobacco product characteristics* affect their potential to cause morbidity and mortality in both users and secondary exposure; including animal and cell culture models as well as novel alternative toxicology approaches that test the toxicity of tobacco smoke, aerosols, or specific constituents in tobacco. Priorities include:
- Toxicological assays (in vivo and in vitro) to compare toxicity across different types of tobacco products within the same class including ENDS, cigars, waterpipes, and smokeless tobacco;
- How product design characteristics* (variation(s) in those characteristics*) impact constituent exposure and toxicity from tobacco products;
- Biomarkers to assess exposure, as well as biomarkers to assess harm or toxicity of non-cigarette tobacco products, including ENDS;
- Toxicological impact of nicotine, flavors, and other constituents across different routes of exposure.
Overview
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