ADME Genes

This example is currently in draft.

This example shows findings from an assessment of genomic variations in drug metabolizing genes with the purpose of determining how variations in those genes affect drug absorption, distribution, metabolism, and excretion (ADME). The method of used to summarize nucleotide variation is represented in variable GFANMETH where appropriate. Identifying information for the genomic panel is represented in SPDEVID. Additional information about the genomic panel may be represented in the Medical Device Domains (e.g., DI domain) as needed.

Add Tags in Examples Collection for CYP450, UGT1A1

Rows 1-6, 9-14	Show variation at a particular allele for the single nucleotide variation identified in GFPVRID. An arbitrary identifier for the allele is represented in GFCOPYID.
Rows 7,15	Show the predicted phenotype based on the unique pattern of nucleotide variation of gene CYP2C19 that is involved in ADME.
Row 8, 16	Show the predicted diplotype based on the unique pattern of nucleotide variation of gene CYP2C19 that is involved in ADME.

Row Captions Debug Message

Please construct row caption labels as instructed in <ac:link><ri:page ri:content-title="Constructing labels for row captions" ri:space-key="TTD"/></ac:link>.

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Row	STUDYID	DOMAIN	USUBJID	SPDEVID	GFSEQ	GFREFID	GFTESTCD	GFTEST	GFTSTDTL	GFORRES	GFSTRESC	GFGENREF	GFCHROM	GFSYM	GFSYMTYP	GFGENLOC	GFPVRID	GFCOPYID	GFNAM	GFSPEC	GFMETHOD	GFANMETH	VISITNUM	VISIT	VISITDY	GFDTC	GFDY
1	ABC123	GF	100001	DMET Plus	1	A566575	SNV	Single Nucleotide Variation	ALLELE SEQUENCE	C	C	GRCh37	10	CYP2C19	GENE WITH PROTEIN PRODUCT	96521657	rs12248560	1	ACME Genomics	DNA	MICROARRAY		-1	SCREENING	-1	2022-04-02	-2
2	ABC123	GF	100001	DMET Plus	2	A566575	SNV	Single Nucleotide Variation	ALLELE SEQUENCE	C	C	GRCh37	10	CYP2C19	GENE WITH PROTEIN PRODUCT	96521657	rs12248560	2	ACME Genomics	DNA	MICROARRAY		-1	SCREENING	-1	2022-04-02	-2
3	ABC123	GF	100001	DMET Plus	3	A566575	SNV	Single Nucleotide Variation	ALLELE SEQUENCE	A	A	GRCh37	10	CYP2C19	GENE WITH PROTEIN PRODUCT	96541616	rs4244285	1	ACME Genomics	DNA	MICROARRAY		-1	SCREENING	-1	2022-04-02	-2
4	ABC123	GF	100001	DMET Plus	4	A566575	SNV	Single Nucleotide Variation	ALLELE SEQUENCE	G	G	GRCh37	10	CYP2C19	GENE WITH PROTEIN PRODUCT	96541616	rs4244285	2	ACME Genomics	DNA	MICROARRAY		-1	SCREENING	-1	2022-04-02	-2
5	ABC123	GF	100001	DMET Plus	5	A566575	SNV	Single Nucleotide Variation	ALLELE SEQUENCE	G	G	GRCh37	10	CYP2C19	GENE WITH PROTEIN PRODUCT	96540410	rs4986893	1	ACME Genomics	DNA	MICROARRAY		-1	SCREENING	-1	2022-04-02	-2
6	ABC123	GF	100001	DMET Plus	6	A566575	SNV	Single Nucleotide Variation	ALLELE SEQUENCE	G	G	GRCh37	10	CYP2C19	GENE WITH PROTEIN PRODUCT	96540410	rs4986893	2	ACME Genomics	DNA	MICROARRAY		-1	SCREENING	-1	2022-04-02	-2
7	ABC123	GF	100001	DMET Plus	7	A566575	VARPROF	Variant Profile	PREDICTED PHENOTYPE	IM	IM			CYP2C19	GENE WITH PROTEIN PRODUCT				ACME Genomics	DNA	MICROARRAY	ADME VARIANT PROFILE	-1	SCREENING	-1	2022-04-02	-2
8	ABC123	GF	100001	DMET Plus	8	A566575	VARPROF	Variant Profile	PREDICTED DIPLOTYPE	1/2	1/2			CYP2C19	GENE WITH PROTEIN PRODUCT				ACME Genomics	DNA	MICROARRAY	ADME VARIANT PROFILE	-1	SCREENING	-1	2022-04-02	-2
9	ABC123	GF	100002	DMET Plus	1	A899790	SNV	Single Nucleotide Variation	ALLELE SEQUENCE	C	C	GRCh37	10	CYP2C19	GENE WITH PROTEIN PRODUCT	96521657	rs12248560	1	ACME Genomics	DNA	MICROARRAY		-1	SCREENING	-1	2022-04-13	-1
10	ABC123	GF	100002	DMET Plus	2	A899790	SNV	Single Nucleotide Variation	ALLELE SEQUENCE	C	C	GRCh37	10	CYP2C19	GENE WITH PROTEIN PRODUCT	96521657	rs12248560	2	ACME Genomics	DNA	MICROARRAY		-1	SCREENING	-1	2022-04-13	-1
11	ABC123	GF	100002	DMET Plus	3	A899790	SNV	Single Nucleotide Variation	ALLELE SEQUENCE	G	G	GRCh37	10	CYP2C19	GENE WITH PROTEIN PRODUCT	96541616	rs4244285	1	ACME Genomics	DNA	MICROARRAY		-1	SCREENING	-1	2022-04-13	-1
12	ABC123	GF	100002	DMET Plus	4	A899790	SNV	Single Nucleotide Variation	ALLELE SEQUENCE	G	G	GRCh37	10	CYP2C19	GENE WITH PROTEIN PRODUCT	96541616	rs4244285	2	ACME Genomics	DNA	MICROARRAY		-1	SCREENING	-1	2022-04-13	-1
13	ABC123	GF	100002	DMET Plus	5	A899790	SNV	Single Nucleotide Variation	ALLELE SEQUENCE	G	G	GRCh37	10	CYP2C19	GENE WITH PROTEIN PRODUCT	96540410	rs4986893	1	ACME Genomics	DNA	MICROARRAY		-1	SCREENING	-1	2022-04-13	-1
14	ABC123	GF	100002	DMET Plus	6	A899790	SNV	Single Nucleotide Variation	ALLELE SEQUENCE	G	G	GRCh37	10	CYP2C19	GENE WITH PROTEIN PRODUCT	96540410	rs4986893	2	ACME Genomics	DNA	MICROARRAY		-1	SCREENING	-1	2022-04-13	-1
15	ABC123	GF	100002	DMET Plus	7	A899790	VARPROF	Variant Profile	PREDICTED PHENOTYPE	EM	EM			CYP2C19	GENE WITH PROTEIN PRODUCT				ACME Genomics	DNA	MICROARRAY	ADME VARIANT PROFILE	-1	SCREENING	-1	2022-04-13	-1
16	ABC123	GF	100002	DMET Plus	8	A899790	VARPROF	Variant Profile	PREDICTED DIPLOTYPE	1/1	1/1			CYP2C19	GENE WITH PROTEIN PRODUCT				ACME Genomics	DNA	MICROARRAY	ADME VARIANT PROFILE	-1	SCREENING	-1	2022-04-13	-1

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ADME Genes