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HPHC testing

Aerosol data used data from: https://www.mdpi.com/2297-8739/8/10/168/htm was from a 3% nicotine solution.

Data for acetaldehyde in solution from Chemical evaluation of electronic cigarettes | Tobacco Control (bmj.com), calculation below

Tobacco product HPHC testing results are represented in the PT domain. This example assume testing at a single time point, not serial testing over multiple timepoints as in stability studies. See the Stability Studies section for more information and examples on handling those data.shows HPHC testing with an ENDS device.HPHC testing is conducted on samples of the product of interest, and (if applicable) samples of comparison products. Each product tested would have its own unique sponsor-defined value for SPTOBID to identify the product. 

This example only shows test results for each constituent for one replicate of one sample of one product that was tested. Details of the sampling and testing plan, including the number of samples of the products tested, are determined by the sponsor or by regulatory requirement.  Sponsors would likely have multiple product samples tested in multiple replicates, and those would be distinguished in the dataset.


The following references were used as guidance for the example below: 1.

  1. Aerosol data used data from: https://www.mdpi.com/2297-8739/8/10/168/htm was from a 3% nicotine solution.

       2. Data for acetaldehyde in solution from Chemical evaluation of electronic cigarettes | Tobacco Control (bmj.com), calculation belowecigstats.org/docs/research/CoA_1R6F.pdf
2. https://open.canada.ca/data/en/dataset/71394df3-aee8-4117-92cb-a035360972a2/resource/7e6b0457-051e-4620-befc-8e4f50b75345 

Dataset wrap
Namept
Rowcaps
Rows 1-2:Show the HPHC testing performed for two constituents on Batch 1, Replication 1 for the liquid matrix. The CAS number of the constituent is provided in PTCAS.
Rows 3-5:Shows the HPHC testing performed for three constituents using the NON-INTENSE SMOKING REGIME for BATCH 1 and Replicate 1.
Rows 6-7:Shows the HPHC testing performed for three constituents using the INTENSE SMOKING REGIME for BATCH 1 and Replicate 1.
Dataset2
RowSTUDYIDDOMAINSPTOBIDSPDEVIDPTSEQPTREFIDPTSPIDPTCASPTTESTCDPTTESTPTCATPTSCATPTORRESPTORRESUPTSTRESCPTSTRESNPTSTRESUPTSPECPTMETHODPTREPNUMPTDTC
1TOB08PTENDS02a
1Batch 101since we started with using PTREFID for the Smoking Regimen in the Cig. example, The batch number could go here. It seems like Smoking Regimen is a method though.75-07-0ACETALDAcetaldehydeHPHC TESTINGHPHC7.9µg/mL7.97.9µg/mLE-LIQUID
12022-09-30
2TOB08PTENDS02aPUFFMASTER3K2Batch 101
1954-11-05NICNicotineHPHC TESTINGHPHC53.5µg/puff53.553.5µg/puffAEROSOLNon-intense12022-09-30
3TOB08PTENDS02aPUFFMASTER3K3Batch 101
75-07-0ACETALDAcetaldehydeHPHC TESTINGHPHC34.7ng/puff34.734.7ng/puffAEROSOLNon-intense12022-09-30
4TOB08PTENDS02aPUFFMASTER3K4Batch 101


Benzoic AcidHPHC TESTINGOther43.3µg/puff43.343.3µg/puffAEROSOLNon-intense12022-09-30
5TOB08PTENDS02aPUFFMASTER3K5Batch 101
1954-11-05NICNicotineHPHC TESTINGHPHC105µg/puff105105µg/puffAEROSOLIntense22022-09-30
6TOB08PTENDS02aPUFFMASTER3K6Batch 101
75-07-0ACETALDAcetaldehydeHPHC TESTINGHPHC43.5ng/puff43.543.5ng/puffAEROSOLIntense22022-09-30
7TOB08PTENDS02aPUFFMASTER3K7Batch 101


Benzoic AcidHPHC TESTINGOther84.1µg/puff84.184.1µg/puffAEROSOLIntense22022-09-30

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