Immunohistochemistry (IHC) is a method that involves treating tissue with a stain that adheres to very specific substances. IHC is the method most commonly used to assess the amount of HER2 receptor protein on the surface of the cancer cells. A cell with too many receptors receives too many growth signals. In this study, IHC assessment of HER2 in samples of breast cancer tissue yielded staining intensity on a scale of 0 to 3+. Staining intensity values of 0 to 1+ were categorized as negative; values of 2+ and 3+ were categorized as positive.

Row 1:Shows a subject with a receptor protein stain intensity value of "0", categorized in MIRESCAT as "NEGATIVE".
Row 2:Shows a subject with a receptor protein stain intensity value of "2+", categorized in MIRESCAT as "POSITIVE".

mi.xpt

mi.xpt

RowSTUDYIDDOMAINUSUBJIDMISEQMITESTCDMITESTMITSTDTLMIORRESMISTRESCMIRESCATMISPECMILOCMIMETHODVISITMIDTC
1ABCMIABC-10011HER2Human Epidermal Growth Factor Receptor 2STAINING INTENSITY00NEGATIVETISSUEBREASTIHCSCREENING2001-06-15
2ABCMIABC-20021HER2Human Epidermal Growth Factor Receptor 2STAINING INTENSITY2+2+POSITIVETISSUEBREASTIHCSCREENING2001-06-15
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