This example shows the definition of 2 data subsets, each of which is a based on a simple condition represented as an instance of the DataSubset class within the dataSubets attribute of the reporting event.
Lines 2-12: | Show the "Treatment-Emergent Adverse Events" data subset defined as a simple condition (line 7) that specifies that the value of the TRTEMFL variable in the ADAE dataset is equal to "Y". This condition could be expressed as:
The sponsor chose to assign a label of "TEAE" for this data subset (line 4). |
Lines 13-32: | Show the "Related Treatment-Emergent Adverse Events" data subset, which the sponsor chose to label as "Related TEAE" (line 15). This data subset is defined as a compound expression (line 18) that combines 2 subclauses using the "AND" logical operator (line 19). Lines 21-23: Show the first subclause defined as an instance of the ReferencedDataSubset class that references the instance of the DataSubset class identified as "Dss01_TEAE" (line 22). Lines 24-32: Show the second subclause defined as a simple condition that specifies that the value of the AEREL variable in the ADAE dataset is either "POSSIBLE" or "PROBABLE". This subclause condition could be expressed as:
When the condition for the data subset referenced by the first subclause is retrieved and combined with the condition for the second subclause using the specified logical operator, this compound expression could be expressed as:
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Lines 33-42: | Show the "Vital Signs Analysis Records" data subset defined as a simple condition (line 37) that specifies that the value of the ANL01FL variable in the ADVS dataset is equal to "Y". This condition could be expressed as:
The sponsor chose not to assign a label for this data subset. |
dataSubsets: - id: Dss01_TEAE name: Treatment-Emergent Adverse Events label: TEAE level: 1 order: 1 condition: dataset: ADAE variable: TRTEMFL comparator: EQ value: - Y - id: Dss02_RelTEAE name: Related Treatment-Emergent Adverse Events label: Related TEAE level: 1 order: 1 compoundExpression: logicalOperator: AND whereClauses: - level: 2 order: 1 subClauseId: Dss01_TEAE - level: 2 order: 2 condition: dataset: ADAE variable: AEREL comparator: IN value: - POSSIBLE - PROBABLE - id: Dss09_VS_AnRec name: Vital Signs Analysis Records level: 1 order: 1 condition: dataset: ADVS variable: ANL01FL comparator: EQ value: - Y
These data subsets could be represented in tabular form as shown in the following table where each data subset and subclause is represented on a separate row, and multiple condition values are represented as a pipe (|)-delimited list.
id | name | label | level | order | logicalOperator | subClauseId | dataset | variable | comparator | value |
---|---|---|---|---|---|---|---|---|---|---|
Dss01_TEAE | Treatment-Emergent Adverse Events | TEAE | 1 | 1 | ADAE | TRTEMFL | EQ | Y | ||
Dss02_RelTEAE | Related Treatment-Emergent Adverse Events | Related TEAE | 1 | 1 | AND | |||||
Dss02_RelTEAE | Related Treatment-Emergent Adverse Events | Related TEAE | 2 | 1 | Dss01_TEAE | |||||
Dss02_RelTEAE | Related Treatment-Emergent Adverse Events | Related TEAE | 2 | 2 | ADAE | AEREL | IN | POSSIBLE|PROBABLE | ||
Dss09_VS_AnRec | Vital Signs Analysis Records | 1 | 1 | ADVS | ANL01FL | EQ | Y |