Immunotherapy Response and Tumor Mutation Burden

This example is currently in draft.

This example shows findings from an assessment of the number of mutations within a tumor genome with the purpose of determining likely response to immunotherapy. (Need to add description here)

gf.xpt

STUDYID	DOMAIN	USUBJID	SPDEVID	GFSEQ	GFREFID	GFTESTCD	GFTEST	GFTSTDTL	GFORRES	GFORRESU	GFSTRESC	GFSTRESN	GFSTRESU	GFGENREF	GFNAM	GFSPEC	GFMETHOD	GFANMETH	VISITNUM	VISIT	VISITDY	GFDTC	GFDY
ABC-123	GF	ABC123-45-001	ACME 500 GENE PANEL	1	96757855	TMB	Tumor Mutation Burden	NORMALIZED NUMBER OF SEQUENCE VARIANTS	8.83	/MBP	8.83	8.83	/MBP	GRCh37.75	ACME Genetics Inc.	ctDNA	NEXT GENERATION TARGETED SEQUENCING	Uniform TMB Calculation Method Merino et al 2020 FORMULA	1	SCREENING	<ADD HERE>	<ADD HERE>	<ADD HERE>
ABC-123	GF	ABC123-45-001	ACME 500 GENE PANEL	2	96757855	TMB	Tumor Mutation Burden	VARIANT SEQUENCE BURDEN INTERPRETATION	intermediate		intermediate			GRCh37.75	ACME Genetics Inc.	ctDNA	NEXT GENERATION TARGETED SEQUENCING		1	SCREENING	<ADD HERE>	<ADD HERE>	<ADD HERE>
ABC-123	GF	ABC123-45-001		3	78975864	TMB	Tumor Mutation Burden	NUMBER OF SEQUENCE VARIANTS	497		497	497		GRCh37.75	Genetics Lab Plus	DNA	WHOLE EXOME SEQUENCING		1	SCREENING	<ADD HERE>	<ADD HERE>	<ADD HERE>

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Immunotherapy Response and Tumor Mutation Burden