Late Gadolinium Enhancement (LGE) is an assessment made with CMR imaging that includesr gadolinium contrast administration. The test is done to assess for gadolinium contrast material accumulation in the tissue with increased extracellular space to determine both left and right ventricle fibrosis (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801263/). For LGE, the assessment relates to the timing of the reading showing whether or not the contrast is present or not at the specific time of the reading (would be determined by the protocol but typically is noted approximately 10 minutes after contrast injection). If the LGE is noted as present, more assessments may be done such as presence per segment and the percentage of presence per segment.
Is "CARDIAC WALL" okay for location?
It is the only term in CT that fits. It seems wrong because technically if there is a mass within the heart, it would be seen on the CMR imaging.
All the segments in the CT is for the LV, is it safe to assume the same segments for RV?
Request SME review and update of text and values.
Note from standards discussion - Determined this would be an indicator test and there is an additional term LGE percentage. → is there anything different to do with this?
The Procedures (PR) dataset is an interventions domain that represents diagnostic, preventive, and therapeutic activity. The PR dataset shows the cardiac magnetic resonance imaging with two different MR machines.
Row 1:
Shows a cardiac MRI for subject 201.
Row 2:
Shows a cardiac MRI for subject 202 with a different MRI machine.
pr.xpt
pr.xpt
Row
STUDYID
DOMAIN
USUBJID
SPDEVID
PRSEQ
PRREFID
PRLNKID
PRTRT
PRLOC
PRFAST
PRSTDTC
1
DMD-LGE
PR
201
ABC001
1
12345678
04
CARDIAC MAGNETIC RESONANCE IMAGING
CARDIAC WALL
Y
2023-07-01T08:55:00
2
DMD-LGE
PR
202
ABC002
2
98765432
05
CARDIAC MAGNETIC RESONANCE IMAGING
CARDIAC WALL
N
2020-07-02T10:05:00
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The Cardiovascular System Findings (CV) dataset contains physiological and morphological findings related to the cardiovascular system, including the heart, blood vessels and lymphatic vessels. The findings from the CMR procedure for LGE are noted in this example.
Rows 1-5:
Show the late gadolinium enhancement (LGE) is present and affecting 4 segments with corresponding percentage for each segment for subject 201.
Row 6:
Shows the late gadolinium enhancement (LGE) is absent for subject 202.
cv.xpt
cv.xpt
Row
STUDYID
DOMAIN
USUBJID
CVSEQ
CVLNKID
CVTESTCD
CVTEST
CVORRES
CVORRESU
CVSTRESC
CVSTRESN
CVSTRESU
CVLOC
CVMETHOD
VISITNUM
VISIT
CVDTC
1
DMD-LGE
CV
201
1
04
LATE GADOLINIUM ENHANCEMENT
PRESENT
PRESENT
CARDIAC MAGNETIC RESONANCE IMAGING
1
SCREENING
2023-07-01
2
DMD-LGE
CV
201
2
04
LATE GADOLINIUM ENHANCEMENT (# of segments)
4
4
4
CARDIAC MAGNETIC RESONANCE IMAGING
1
SCREENING
2023-07-01
3
DMD-LGE
CV
201
3
04
LGEPER
LATE GADOLINIUM ENHANCEMENT PERCENTAGE
20
%
20
20
%
LEFT VENTRICULAR BASAL ANTERIOR SEGMENT
CARDIAC MAGNETIC RESONANCE IMAGING
1
SCREENING
2023-07-01
4
DMD-LGE
CV
201
4
04
LGEPER
LATE GADOLINIUM ENHANCEMENT PERCENTAGE
30
%
30
30
%
LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT
CARDIAC MAGNETIC RESONANCE IMAGING
1
SCREENING
2023-07-01
5
DMD-LGE
CV
201
5
04
LGEPER
LATE GADOLINIUM ENHANCEMENT PERCENTAGE
45
%
45
45
%
LEFT VENTRICULAR MID INFERIOR SEGMENT
CARDIAC MAGNETIC RESONANCE IMAGING
1
SCREENING
2023-07-01
5
DMD-LGE
CV
201
6
04
LGEPER
LATE GADOLINIUM ENHANCEMENT PERCENTAGE
50
%
50
50
%
RIGHT VENTRICULAR MID INFERIOR SEGMENT
CARDIAC MAGNETIC RESONANCE IMAGING
1
SCREENING
2023-07-01
1
DMD-LGE
CV
202
1
05
LATE GADOLINIUM ENHANCEMENT
ABSENT
ABSENT
CARDIAC MAGNETIC RESONANCE IMAGING
1
SCREENING
2023-07-01
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The Procedure Agent (AG) dataset is an interventions domain that contains the agents administered to the subject as part of a procedure or assessment. The AG dataset shows the timing of the Gadolinium based contrast, GD-DOTA.