Title	ASSIGN Risk Score (ASSIGN CVD 10-YEAR RISK)
CDISC Reference	Clinical Classifications Supplement to the Study Data Tabulation Model Implementation Guide for Human Clinical Trials
QRS Short Name	(ASSIGN CVD 10-YEAR RISK)
QRS Permission Status	Public Domain
Team	Dyslipidemia Standards Team and CDISC QRS Sub-Team
Supplement Version	2.0
Status	FINAL
Date	2023-XX-XX
Notes	This supplement is intended to be used with other CDISC User Guides for specific Therapeutic/Disease Areas and follows the CDISC Study Data Tabulation Model Implementation Guide for Human Clinical trials.

Revision History

Date	Version	Summary of Changes
2023-XX-XX	2.0	ASSIGN CVD 10-YEAR RISK Final Converted the supplement to the current WIKI QRS supplement template. Updated RSTEST name
2016-07-14	1.0	ASSIGN CVD 10-YEAR RISK Final Based on the SDS Team decision to not release the draft CC domain, but include its definition in the RS domain, all references to the CC domain were revised to the RS domain throughout this document.
2015-10-07	1.0	ASSIGN CVD 10-YEAR RISK Draft
2015-01-05	1.0	ASSIGN CVD 10-YEAR RISK Draft

1 Introduction

This document describes the CDISC implementation of the Acute Physiology and Chronic Health Evaluation II (APACHE II) instrument.

CDISC did not modify this questionnaires, ratings, and scales (QRS) instrument to meet Clinical Data Acquisition Standards Harmonization (CDASH) case report form (CRF) standards.

The representation of data collected for this instrument is based on the Study Data Tabulation Model Implementation Guide (SDTMIG) Disease Response and Clin Classification (RS) domain model, which can be found on the CDISC website at: https://www.cdisc.org/standards/foundational/sdtmig.

These specific implementation details for this instrument are meant to be used in conjunction with the SDTMIG. All CDISC QRS documentation packages can be found on the CDISC website at: https://www.cdisc.org/standards/foundational/qrs.

The CDISC Intellectual Property Policy can be found on the CDISC website at: https://www.cdisc.org/about/bylaws.

1.1 Representations and Warranties, Limitations of Liability, and Disclaimers

This document is a supplement to the SDTMIG for Human Clinical Trials and is covered under Appendix F of that document, which describes representations, warranties, limitations of liability, and disclaimers. Please see Appendix F of the SDTMIG for a complete version of this material.

CDISC specifies how to structure the data that has been collected in a database, not what should be collected or how to conduct clinical assessments or protocols. CDISC disclaims any liability for your use of this material.

2 Copyright Status

CDISC believes this instrument to be in the public domain, but you should perform your own assessment. CDISC has included the APACHE II in the CDISC inventory of QRS data standards supplements. Hence, CDISC developed RSTESTCD and RSTEST for each item based on the actual text on the instrument. There may be many versions of this instrument. CDISC has chosen to use this version as the data standard.

The CDISC documentation of this instrument consists of: (1) controlled terminology, (2) standard database structure with examples, and (3) CRF(s) annotated with the CDISC SDTMIG variables with submission values.

Note: CDISC Controlled Terminology is maintained by National Cancer Institute (NCI) Enterprise Vocabulary Services (EVS). The most recent version should be accessed through the CDISC website at: https://www.cdisc.org/standards/terminology/controlled-terminology.

Reference for the APACHE II:

Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Critical Care Medicine 1985; 13(10):818–29.

3 The RS Domain Model

3.1 Assumptions for the RS Domain Model

All assumptions and business rules described in the SDTMIG RS domain are applicable to this supplement. Additional assumptions specific to the APACHE II are listed below.

The QRS APACHE II is a severity-of-disease classification system that uses a point score based on the initial values of 12 routine physiologic measurements, age, and previous health status. Scores range from 0 to 71 and higher scores correspond to more severe disease and a higher risk of death. The composite score is based on findings represented in other SDTM domains such as Laboratory Test Results (LB) and Vital Signs (VS).

The APACHE II provides weightings for 12 physiology measures, the sum of which yields a total acute physiology score (APS). This weighting system for 11 of the physiology measures is based on a numeric rating scale (0-4) where 0 reflects values within the normal range and an increase in the numeric rating scale represents an increase in the abnormality of the physiology measure in either the high or low direction.
1. For example, the rating of 4 for heart rate (ventricular response) may coincide with multiple definitions depending on whether the abnormality is in the high or low direction (e.g., 4 = ">=180" or 4 = "<=39", respectively).
2. Note that the score for the Glasgow Coma Score (GCS), the final physiology measure, is the reverse; lower scores indicate mild or no head injury and higher scores represent more severe head injury.
3. Age and severe chronic health problems reflect diminished physiologic reserve; these have been directly incorporated into APACHE II. Chronological age is a well-documented risk factor for death from acute illness that is independent of severity of disease. This item includes a numeric rating (0, 2, 3, 5, 6) and a definition of what is represented by the rating (e.g., 6 = ">=75" years in age).
4. Severe chronic organ system insufficiency or immunocompromised state markedly influenced outcome. Nonoperative and emergency surgery admissions had a substantially higher risk for death from prior chronic conditions than did elective surgical admissions. This indicates that patients with the most severe chronic conditions are not considered to be candidates for elective surgery. For patients with a history of severe organ system insufficiency or who are immunocompromised, a numeric rating of 2 or 5 is assigned for chronic health points, where 2 is assigned “for elective postoperative patients” and 5 is assigned “for nonoperative or emergency postoperative patients”.
5. For the APACHE II, RSORRES is populated with the text description; the numeric rating is represented in the standardized character and numeric result variables RSSTRESC and RSSTRESN.
Records are created in rs.xpt (or in split rsap.xpt) for every item on the instrument.
1. For items with no data, RSORRES, RSSTRESC, and RSSTRESN are all missing and RSSTAT = "NOT DONE". If the reason is known then that reason is represented in RSREASND (e.g., RSREASND = "PREFER NOT TO ANSWER"). If the reason is unknown, then RSSTAT = "NOT DONE" and RSREASND is missing.
Some items on the QRS APACHE II may be not done due to conditional branching per the instrument instructions.
1. The equation for computing the alveolar-arterial O₂ gradient is heavily dependent on inspired O₂ levels, so there are 2 methods for calculating oxygenation. When inspired O₂ levels ≥ 0.5 use the alveolar-arterial O₂ gradient and complete RSTESTCD = "APCH105A". When inspired O₂ levels < 0.5 use the partial pressure of oxygen (PaO₂) and complete RSTESTCD = "APCH105B". The other will be treated as not done due to conditional branching.
2. In addition, arterial pH (RSTESTCD = "APCH106A") is preferred but in cases where oxygenation is normal and blood gases are not measured, serum HCO₃ (RSTESTCD = "APCH106B") can be substituted. Only 1 of these 2 physiological parameters will be measured and the other will be treated as not done due to conditional branching.
3. In addition, a chronic health response, item RSTESTCD = "APCH115", is only assigned (along with the points) when the patient has a history of severe organ system insufficiency or is immunocompromised. Otherwise it will be not done due to conditional branching.
4. A record is created in rs.xpt for all items. When an item is considered conditionally branched, it is represented as follows:
  1. RSSTAT = "NOT DONE"
  2. RSDRVFL = "Y" (the record is derived as a "NOT DONE" record)
  3. QNAM = “RSCBRFL”, QLABEL = “Conditional Branched Item Indicator “, QVAL = “Y” (RS supplemental qualifier variable)
  4. RSORRES, RSSTRESC, and RSSTRESN are set to null (missing)
The APACHE II instrument includes a total APS and total APACHE II score which are considered as captured data on the CRF and not considered as derived in the example below. These scores may be submitted in SDTM or derived in the Analysis Data Model (ADaM) per scoring instructions on the CRF. If scores are received by the sponsor,
1. It is recommended that they are submitted to SDTM and verified in ADaM.
Terminology
1. RSCAT, RSTESTCD, RSTEST, and RSORRESU values are included in CDISC Controlled Terminology.
2. A full list of value sets for the result and unit fields are provided in Section 4, SDTM Mapping Strategy.

3.2 Example for the QRS APACHE II RS Domain Model

The rsap.xpt dataset represents the items from the APACHE II. The RS domain was split into 2 physically separate datasets: the APACHE II instrument (rsap.xpt) and the GCS (rsgc.xpt). Each dataset represents a subset of the RS domain. Note: In this example, the vital sign and lab values used to answer the APACHE II items were also collected and represented separately in the VS and LB domains. RSLNKID is used to link the APACHE II records to their corresponding findings in their respective source domains. This relationship is defined in the RELREC table.

The APACHE II example below shows the terminology used to implement the instrument in the RS domain. This example shows the data for 2 subjects collected at visit 1 for the APACHE II instrument. The example uses CDISC Controlled Terminology for RSTESTCD, RSTEST, RSCAT, and RSORRESU. All original results, matching the CRF item response text, are represented in RSORRES. This result is then represented as a standard numeric score in RSSTRESN and as a standard character representation in RSSTRESC

The table represents the items from the APACHE II instrument.

Rows 1-4:	Represent the 4 APACHE II items that are based on vital sign measurements.
Rows 5-13:	Represent the APACHE II items that are based on lab measurements.
Rows 5-6:	Show that this subject was evaluated for oxygenation (mmHg) where FIO₂ is less than 0.5, so PaO₂ is recorded. Oxygenation (mmHg) for A-aDO₂,where FIO₂ is greater than or equal to 0.5, is shown as not done due to conditional branching.
Rows 7-8:	Show that this subject was evaluated for arterial pH. Serum HCO₃ (venous mmol/L) is shown as not done due to conditional branching since arterial pH is preferred when arterial blood gases are available.
Row 11:	For serum creatinine (mg/dL), subjects will receive double point score for acute renal failure. This subject has normal renal function.
Row 14:	Represents the APACHE II item that is based on the score of a separate RS instrument, the GCS. RSORRES, RSSTRESC, and RSSTRESN represent the ordinal value obtained as per the APACHE II instructions. RSGRPID serves to group the full GCS records, which are represented in a separate RS dataset, split by RSCAT.
Row 15:	Represents the total APS, which is calculated from the preceding 12 APACHE II measures according to instructions on the instrument.
Rows 16-17:	Represent an additional 2 items which are collected on the APACHE II instrument (age points and chronic health points, respectively). The answers to these items are not based on physiological measurements and therefore are not linked to records in any other domains.
Row 18:	Represents the total APACHE II score as collected on the instrument according to instructions.
Rows 19-36:	Show the subject was not evaluated on this instrument at visit 1. A record for each item on the instrument is created with a status of "NOT DONE". Since the reason for not completing the visit was not collected, no date is assumed for when the visit would have occurred. No assumptions are made about which items were not done based on conditional branching.

rs.xpt

Row	STUDYID	DOMAIN	USUBJID	RSSEQ	RSGRPID	RSLNKID	RSTESTCD	RSTEST	RSCAT	RSORRES	RSORRESU	RSSTRESC	RSSTRESN	RSSTAT	RSLOBXFL	RSDRVFL	VISITNUM	RSDTC
1	STUDYX	RS	P0001	1		AP01	APCH101	APCH1-Temperature - Rectal	APACHE II	38.5-38.9	C	1	1		Y		1	2014-06-24
2	STUDYX	RS	P0001	2		AP02	APCH102	APCH1-Mean Arterial Pressure	APACHE II	110-129	mmHg	2	2		Y		1	2014-06-24
3	STUDYX	RS	P0001	3		AP03	APCH103	APCH1-Heart Rate	APACHE II	70-109	beats/min	0	0		Y		1	2014-06-24
4	STUDYX	RS	P0001	4		AP04	APCH104	APCH1-Respiratory Rate	APACHE II	>=50	breaths/min	4	4		Y		1	2014-06-24
5	STUDYX	RS	P0001	5			APCH105A	APCH1-Oxygenation: A-aDO2	APACHE II					NOT DONE	Y	Y	1	2014-06-24
6	STUDYX	RS	P0001	6		AP05	APCH105B	APCH1-Oxygenation: PaO2	APACHE II	61-70	mmHg	1	1		Y		1	2014-06-24
7	STUDYX	RS	P0001	7		AP06	APCH106A	APCH1-Arterial pH	APACHE II	<7.15		4	4		Y		1	2014-06-24
8	STUDYX	RS	P0001	8			APCH106B	APCH1-Serum HCO3	APACHE II					NOT DONE	Y	Y	1	2014-06-24
9	STUDYX	RS	P0001	9		AP07	APCH107	APCH1-Serum Sodium	APACHE II	150-154	mmol/L	1	1		Y		1	2014-06-24
10	STUDYX	RS	P0001	10		AP08	APCH108	APCH1-Serum Potassium	APACHE II	3.5-5.4	mmol/L	0	0		Y		1	2014-06-24
11	STUDYX	RS	P0001	11		AP09	APCH109	APCH1-Serum Creatinine	APACHE II	<0.6	mg/dL	2	2		Y		1	2014-06-24
12	STUDYX	RS	P0001	12		AP10	APCH110	APCH1-Hematocrit	APACHE II	20-29.9	%	2	2		Y		1	2014-06-24
13	STUDYX	RS	P0001	13		AP11	APCH111	APCH1-White Blood Count	APACHE II	>=40	10^9/L	4	4		Y		1	2014-06-24
14	STUDYX	RS	P0001	14	1		APCH112	APCH1-15 Minus Glasgow Coma Score	APACHE II	3		3	3		Y		1	2014-06-24
15	STUDYX	RS	P0001	15			APCH113	APCH1-A: Total Acute Physiology Score	APACHE II	24		24	24		Y		1	2014-06-24
16	STUDYX	RS	P0001	16			APCH114	APCH1-B: Age Points	APACHE II	65-74	YEARS	5	5		Y		1	2014-06-24
17	STUDYX	RS	P0001	17			APCH115	APCH1-C: Chronic Health Points	APACHE II	for elective postoperative patients		2	2		Y		1	2014-06-24
18	STUDYX	RS	P0001	18			APCH116	APCH1-Total APACHE II Score	APACHE II	31		31	31		Y		1	2014-06-24
19	STUDYX	RS	P0002	1			APCH101	APCH1-Temperature - Rectal	APACHE II					NOT DONE			1
20	STUDYX	RS	P0002	2			APCH102	APCH1-Mean Arterial Pressure	APACHE II					NOT DONE			1
21	STUDYX	RS	P0002	3			APCH103	APCH1-Heart Rate	APACHE II					NOT DONE			1
22	STUDYX	RS	P0002	4			APCH104	APCH1-Respiratory Rate	APACHE II					NOT DONE			1
23	STUDYX	RS	P0002	5			APCH105A	APCH1-Oxygenation: A-aDO2	APACHE II					NOT DONE			1
24	STUDYX	RS	P0002	6			APCH105B	APCH1-Oxygenation: PaO2	APACHE II					NOT DONE			1
25	STUDYX	RS	P0002	7			APCH106A	APCH1-Arterial pH	APACHE II					NOT DONE			1
26	STUDYX	RS	P0002	8			APCH106B	APCH1-Serum HCO3	APACHE II					NOT DONE			1
27	STUDYX	RS	P0002	9			APCH107	APCH1-Serum Sodium	APACHE II					NOT DONE			1
28	STUDYX	RS	P0002	10			APCH108	APCH1-Serum Potassium	APACHE II					NOT DONE			1
29	STUDYX	RS	P0002	11			APCH109	APCH1-Serum Creatinine	APACHE II					NOT DONE			1
30	STUDYX	RS	P0002	12			APCH110	APCH1-Hematocrit	APACHE II					NOT DONE			1
31	STUDYX	RS	P0002	13			APCH111	APCH1-White Blood Count	APACHE II					NOT DONE			1
32	STUDYX	RS	P0002	14			APCH112	APCH1-15 Minus Glasgow Coma Score	APACHE II					NOT DONE			1
33	STUDYX	RS	P0002	15			APCH113	APCH1-A: Total Acute Physiology Score	APACHE II					NOT DONE			1
34	STUDYX	RS	P0002	16			APCH114	APCH1-B: Age Points	APACHE II					NOT DONE			1
35	STUDYX	RS	P0002	17			APCH115	APCH1-C: Chronic Health Points	APACHE II					NOT DONE			1
36	STUDYX	RS	P0002	18			APCH116	APCH1-Total APACHE II Score	APACHE II					NOT DONE			1

$warningHtml

Dataset Wrapper Debug Message

Please add a row column to your dataset.

The following dataset represents source-data GCS scores which were input into the APACHE II. Note that RSSEQ is set to start at 101 for each subject within this split RS domain as APACHE II is only collected once during the study (at VISITNUM=1). RSGRPID in the split domain below matches RSGRPID for the corresponding record in the preceding RS domain example.

dm.xpt

Row	STUDYID	DOMAIN	USUBJID	SUBJID	SEX	BRTHDTC	AGE	AGEU
1	1001	DM	1001-001	1	F	6/24/1972	39	YEARS
2	1001	DM	1001-002	2	M	2/2/1947	65	YEARS

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The following dataset represents source-data vital signs tests that were input into the APACHE II. Note that the result values fall within the ranges contained in RSORRES in the corresponding RS record. VSLNKID matches RSLNKID for each corresponding record in the RS domain example above.

vs.xpt

Row	STUDYID	DOMAIN	USUBJID	VSSEQ	VSLNKID	VSTESTCD	VSTEST	VSORRES	VSORRESU	VSSTRESC	VSSTRESN	VSSTRESU	VSLOC	VSBLFL	VISITNUM	VSDTC
1	STUDYX	VS	P0001	1	AP01	TEMP	Temperature	38.9	C	38.9	38.9	C	RECTUM	Y	1	2014-06-24
2	STUDYX	VS	P0001	2	AP02	MAP	Mean Arterial Pressure	117	mmHg	117	117	mmHg		Y	1	2014-06-24
3	STUDYX	VS	P0001	3	AP03	HR	Heart Rate	98	beats/min	98	98	beats/min		Y	1	2014-06-24
4	STUDYX	VS	P0001	4	AP04	RESP	Respiratory Rate	54	breaths/min	54	54	breaths/min		Y	1	2014-06-24

$warningHtml

The following dataset represents the 7 source-data lab tests that were input into the APACHE II. Note that the result values fall within the ranges contained in RSORRES in the corresponding RS record. LBLNKID matches RSLNKID for each corresponding record in the preceding RS domain example.

lb.xpt

Row	STUDYID	DOMAIN	USUBJID	LBSEQ	LBLNKID	LBTESTCD	LBTEST	LBORRES	LBORRESU	LBSTRESC	LBSTRESN	LBSTRESU	LBSPEC	LBBLFL	VISITNUM	LBDTC
1	STUDYX	LB	P0001	1	AP05	PO2	Partial Pressure Oxygen	65	mmHg	65	65	mmHg	ARTERIAL BLOOD	Y	1	2014-06-24
2	STUDYX	LB	P0001	2	AP06	PH	pH	7.12		7.12	7.12		ARTERIAL BLOOD	Y	1	2014-06-24
3	STUDYX	LB	P0001	3	AP07	SODIUM	Sodium	150	mmol/L	150	150	mmol/L	SERUM	Y	1	2014-06-24
4	STUDYX	LB	P0001	4	AP08	K	Potassium	3.7	mmol/L	3.7	3.7	mmol/L	SERUM	Y	1	2014-06-24
5	STUDYX	LB	P0001	5	AP09	CREAT	Creatinine	0.5	mg/dL	0.5	0.5	mg/dL	SERUM	Y	1	2014-06-24
6	STUDYX	LB	P0001	6	AP10	HCT	Hematocrit	24.6	%	24.6	24.6	%		Y	1	2014-06-24
7	STUDYX	LB	P0001	7	AP11	WBC	Leukocytes	42	10^9/L	42	42	10^9/L		Y	1	2014-06-24

$warningHtml

The following dataset represents the one-to-one relationship (as defined in RELTYPE) between the RS and VS domains and between the RS and LB domains for the APACHE II.

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relrec.xpt

Row	STUDYID	RDOMAIN	IDVAR	RELTYPE	RELID
1	STUDYX	RS	RSLNKID	ONE	1
2	STUDYX	VS	VSLNKID	ONE	1
3	STUDYX	RS	RSLNKID	ONE	2
4	STUDYX	LB	LBLNKID	ONE	2

$warningHtml

4 SDTM Mapping Strategy

This section is used for reference regarding the CRF data capture and to understand the alignment of the instrument to the SDTM RS domain. It also provides guidance on how the result variables (RSORRES, RSSTRESC, RSSTRESN, and RSORRESU) should be populated.

RSTESTCD = "APCH101" RSTEST = "APCH1-Temperature - Rectal"

RSORRES	RSSTRESC	RSSTRESN
>=41	4	4
39-40.9	3	3
38.5-38.9	1	1
36-38.4	0	0
34-35.9	1	1
32-33.9	2	2
30-31.9	3	3
<=29.9	4	4

RSORRESU
C

RSTESTCD = "APCH102" RSTEST = "APCH1-Mean Arterial Pressure"

RSORRES	RSSTRESC	RSSTRESN
>=160	4	4
130-159	3	3
110–129	2	2
70–109	0	0
50–69	2	2
<=49	4	4

RSORRESU
mmHg

RSTESTCD = "APCH103" RSTEST = "APCH1-Heart Rate"

RSORRES	RSSTRESC	RSSTRESN
>=180	4	4
140–179	3	3
110–139	2	2
70–109	0	0
55–69	2	2
40–54	3	3
<=39	4	4

RSORRESU
beats/min

RSTESTCD = "APCH104" RSTEST = "APCH1-Respiratory Rate"

RSORRES	RSSTRESC	RSSTRESN
>=50	4	4
35-49	3	3
25-34	1	1
12-24	0	0
10-11	1	1
6-9	2	2
<=5	4	4

RSORRESU
breaths/min

RSTESTCD = "APCH105A" RSTEST = "APCH1-Oxygenation: A-aDO2"

RSORRES	RSSTRESC	RSSTRESN
>=500	4	4
350-499	3	3
200-349	2	2
<200	0	0

RSORRESU
mmHg

RSTESTCD = "APCH105B" RSTEST = "APCH1-Oxygenation: PaO2"

RSORRES	RSSTRESC	RSSTRESN
>70	0	0
61-70	1	1
55-60	3	3
<55	4	4

RSORRESU
mmHg

RSTESTCD = "APCH106A" RSTEST = "APCH1-Arterial pH"

RSORRES	RSSTRESC	RSSTRESN
>=7.7	4	4
7.6-7.69	3	3
7.5-7.59	1	1
7.33-7.49	0	0
7.25-7.32	2	2
7.15-7.24	3	3
<7.15	4	4

RSTESTCD = "APCH106B" RSTEST = "APCH1-Serum HCO3"

RSORRES	RSSTRESC	RSSTRESN
>=52	4	4
41-51.9	3	3
32-40.9	1	1
22-31.9	0	0
18-21.9	2	2
15-17.9	3	3
<15	4	4

RSORRESU
mmol/L

RSTESTCD = "APCH107" RSTEST = "APCH1-Serum Sodium"

RSORRES	RSSTRESC	RSSTRESN
>=180	4	4
160-179	3	3
155-159	2	2
150-154	1	1
130-149	0	0
120-129	2	2
111-119	3	3
<=110	4	4

RSORRESU
mmol/L

RSTESTCD = "APCH108" RSTEST = "APCH1-Serum Potassium"

RSORRES	RSSTRESC	RSSTRESN
>=7	4	4
6-6.9	3	3
5.5-5.9	1	1
3.5-5.4	0	0
3-3.4	1	1
2.5-2.9	2	2
<2.5	4	4

RSORRESU
mmol/L

RSTESTCD = "APCH109" RSTEST = "APCH1-Serum Creatinine"

RSORRES	RSSTRESC	RSSTRESN
>=3.5 and acute renal failure	8	8
2-3.4 and acute renal failure	6	6
1.5-1.9 and acute renal failure	4	4
>=3.5	4	4
2-3.4	3	3
1.5-1.9	2	2
0.6-1.4	0	0
<0.6	2	2

RSORRESU
mg/dL

RSTESTCD = "APCH110" RSTEST = "APCH1-Hematocrit"

RSORRES	RSSTRESC	RSSTRESN
>=60	4	4
50-59.9	2	2
46-49.9	1	1
30-45.9	0	0
20-29.9	2	2
<20	4	4

RSORRESU
%

RSTESTCD = "APCH111" RSTEST = "APCH1-White Blood Count"

RSORRES	RSSTRESC	RSSTRESN
>=40	4	4
20-39.9	2	2
15-19.9	1	1
3-14.9	0	0
1-2.9	2	2
<1	4	4

RSORRESU
10^9/L

RSTESTCD = "APCH114" RSTEST = "APCH1-B: Age Points"

RSORRES	RSSTRESC	RSSTRESN
<=44	0	0
45-54	2	2
55-64	3	3
65-74	5	5
>=75	6	6

RSORRESU
YEARS

RSTESTCD = "APCH115" RSTEST = "APCH1-C: Chronic Health Points"

RSORRES	RSSTRESC	RSSTRESN
for nonoperative or emergency postoperative patients	5	5
for elective postoperative patients	2	2

End of Document

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ASSIGN Risk Score (ASSIGN CVD 10-YEAR RISK)

1 Introduction

1.1 Representations and Warranties, Limitations of Liability, and Disclaimers

2 Copyright Status

3.1 Assumptions for the RS Domain Model

3.2 Example for the QRS APACHE II RS Domain Model

4 SDTM Mapping Strategy