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  1.  IN is a special purpose domain for listing the non-tobacco ingredients (only) for a tobacco product. Tobacco ingredients, such as individual tobacco varieties would not be represented in this domain (see IT domain specification and assumptions for more information on handling tobacco ingredients).
  2. IN is one of two domains (along with IT) that serve as the origin of the consistent identifier variable IGDCMPID (Ingredient or Component Identifier).
    1. IGDCMPID must represent a non-tobacco ingredient that is unique with regard to the attributes listed in assumption 3 below. If two or more sources of the same non-tobacco ingredient differ on any of these attributes, they must each be assigned a different value for INGCMPID (e.g., 1,3-Butanediol A, 1,3-Butanediol B)
    2. IGDCMPID is used with the same values in the IQ domain where the ingredients identified by those values are quantified by component (See IQ domain specification and assumptions for more information).
  3. Additionally, IN contains variables for representing the following attributes:
    1. Manufacturer's name and registration number
    2. Tobacco Product Master File (TPMF) number
    3. IUPAC name and CAS Registry number. At least one of these variables should be populated if the data are available. 
      1. If an IUPAC name is not available, CASNO should be populated.
      2. The preferred IUPAC name should be used, if available
      3. If both are available, both should be populated.
    4. Ingredient grade and purity
  4.  At least one of the variables IUPAC or CASNO must be populated, if available.
    1. If an IUPAC name is not available, CASNO should be populated.
    2. The preferred IUPAC name should be used, if available
    3. If both are available, both should be populated.
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