Macroscopic Findings (MA)

Example

This example demonstrates additional example findings.

Rows 1-4:	These findings demonstrate original results with modifiers, including a severity, which is copied into MASEV. The base gross observations are entered into MASTRESC, and the remaining modifiers are submitted in MARESMOD supplemental qualifiers.
Row 3:	The left lobe is not qualifying a part of the scheduled sampled specimen (LUNG), but qualifying the finding (as it is present in MAORRES) and, therefore, belongs as a result modifier in supplemental qualifier (MARESMOD) and not in MAANTREG.
Row 4:	The finding demonstrates an original result with a comment that is copied into the Comments domain (see the CO dataset in this example).
Rows 5, 10:	These findings demonstrate original results without modifiers.
Row 6:	This finding demonstrates the use of specimen qualifiers (MAANTREG, MALAT, and MADIR).
Row 7:	This is an example of a reason why a macroscopic evaluation was not done (MAREASND). Note that MAORRES is null and MASTAT is "NOT DONE".
Row 8:	Represents a normal observation applied to all examined tissues for the subject. Note the MASPEC field's value of "ALL TISSUES".
Row 9:	Represents a normal observation for the cecum.

ma.xpt

Row	STUDYID	DOMAIN	USUBJID	MASEQ	MASPID	MATESTCD	MATEST	MAORRES	MASTRESC	MASTAT	MAREASND	MASPEC	MAANTREG	MALAT	MADIR	MASEV	MADTC	MADY
1	123456	MA	123456-1001	1		GROSPATH	Gross Pathological Examination	Discoloration dark, mucosa	Discoloration			LARGE INTESTINE, CECUM					2011-03-23	365
2	123456	MA	123456-1001	2		GROSPATH	Gross Pathological Examination	Foci dark, mucosa	Foci			LARGE INTESTINE, COLON			DISTAL		2011-03-23	365
3	123456	MA	123456-1001	3		GROSPATH	Gross Pathological Examination	Congestion, left lobe moderate	Congestion			LUNG				MODERATE	2011-03-23	365
4	123456	MA	123456-1001	4		GROSPATH	Gross Pathological Examination	Bulla, right caudal lobe, 1 cm in diameter, one section	Bulla			LUNG					2011-03-23	365
5	123456	MA	123456-1001	5		GROSPATH	Gross Pathological Examination	Small	Small			THYMUS					2011-03-23	365
6	123456	MA	123456-1002	6	MASS 1	GROSPATH	Gross Pathological Examination	Mass, approximately 8 mm long, 6 mm wide, 4 mm thick, pale firm well defined	Mass			BONE, FEMUR	STIFLE	LEFT	MEDIAL		2011-03-23	365
7	123456	MA	123456-1002	7		GROSPATH	Gross Pathological Examination			NOT DONE	Tissue lost	GLAND, PITUITARY					2011-03-23	365
8	123456	MA	123456-1003	8		GROSPATH	Gross Pathological Examination	No necropsy observations noted.	UNREMARKABLE			ALL TISSUES					2011-03-23	365
9	123456	MA	123456-1004	9		GROSPATH	Gross Pathological Examination	Normal	UNREMARKABLE			LARGE INTESTINE, CECUM					2011-03-24	366
10	123456	MA	123456-1004	10		GROSPATH	Gross Pathological Examination	Adhesion	Adhesion			LUNG					2011-03-24	366

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Dataset Wrapper Debug Message

Please add a row column to your dataset.

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suppma.xpt

Row	STUDYID	RDOMAIN	USUBJID	IDVAR	IDVARVAL	QNAM	QLABEL	QVAL	QORIG
1	123456	MA	123456-1001	MASEQ	1	MARESMOD	Result Modifiers	dark; mucosa	COLLECTED
2	123456	MA	123456-1001	MASEQ	2	MARESMOD	Result Modifiers	dark; mucosa	COLLECTED
3	123456	MA	123456-1001	MASEQ	3	MARESMOD	Result Modifiers	left lobe	COLLECTED
4	123456	MA	123456-1001	MASEQ	4	MARESMOD	Result Modifiers	right caudal lobe; 1 cm in diameter	COLLECTED
5	123456	MA	123456-1001	MASEQ	6	MARESMOD	Result Modifiers	approximately 8 mm long, 6 mm wide, 4 mm thick; pale; firm; well defined	COLLECTED

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This table demonstrates the representation of the comment which was included in MAORRES.

co.xpt

Row	STUDYID	DOMAIN	RDOMAIN	USUBJID	COSEQ	IDVAR	IDVARVAL	COVAL	CODTC	CODY
1	123456	CO	MA	123456-1001	1	MASEQ	4	one section	2011-03-23	365

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Example

This example demonstrates the use of the domain to record clinical signs follow-up examinations performed at necropsy.

Rows 1-2:	Represents examples of a follow-up of a clinical observation that could not be confirmed at necropsy.
Row 3:	Represents an example of a follow-up of a clinical observation that was confirmed at necropsy.

ma.xpt

Row	STUDYID	DOMAIN	USUBJID	MASEQ	MATESTCD	MATEST	MAORRES	MASTRESC	MADTC	MADY
1	999123	MA	999123-101	16	CLSFUP	Clinical Signs Follow-up	MASS NOT FOUND AT NECROPSY	MASS NOT FOUND AT NECROPSY	2000-01-31T14:33:21	365
2	999123	MA	999123-101	17	CLSFUP	Clinical Signs Follow-up	NOT PRESENT	NOT PRESENT	2000-01-31T14:33:21	365
3	999123	MA	999123-101	18	CLSFUP	Clinical Signs Follow-up	PRESENT	PRESENT	2000-01-31T14:33:21	365

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Dataset Wrapper Debug Message

Please add a row column to your dataset.

This RELREC demonstrates a linking between a specific clinical observation (CLSEQ) and its corresponding clinical sign follow-up at necropsy (MASEQ).

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relrec.xpt

Row	STUDYID	RDOMAIN	USUBJID	IDVAR	IDVARVAL	RELID
1	999123	CL	123456	CLSEQ	47	62
2	999123	CL	123456	CLSEQ	49	63
3	999123	CL	123456	CLSEQ	51	64
4	999123	MA	123456	MASEQ	16	62
5	999123	MA	123456	MASEQ	17	63
6	999123	MA	123456	MASEQ	18	64

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This example demonstrates a linking between findings across the Clinical Observations (CL), Palpable Masses (PM), MA, Microscopic Findings (MI), and Tumor Findings (TF) domains using RELREC. The mass was first identified as an abrasion over several weeks (grouped by CLGRPID = 5), graduating to a mass with several associated clinical findings (identified by a CLSPID of "MASS 2"). These clinical findings correspond to a set of findings in the PM domain, a clinical signs follow-up and gross pathological examination in the MA domain, a single microscopic finding from the MI domain, and a single tumor finding in the TF domain. Each of the findings in the PM, MA, MI, and TF are related by way of the --SPID field, with a value of "MASS 2".

Because all of these records are related, they are given the same RELID (in this case a value of 80).

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relrec.xpt

Row	STUDYID	RDOMAIN	USUBJID	IDVAR	IDVARVAL	RELID
1	PY001002	CL	AA-12540	CLGRPID	5	80
2	PY001002	CL	AA-12540	CLSPID	MASS 2	80
3	PY001002	PM	AA-12540	PMSPID	MASS 2	80
4	PY001002	MA	AA-12540	MASPID	MASS 2	80
5	PY001002	MI	AA-12540	MISPID	MASS 2	80
6	PY001002	TF	AA-12540	TFSPID	MASS 2	80

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Example

These are example records of a macroscopic evaluation of injection sites (as indicated in FOCID).

ma.xpt

Row	STUDYID	DOMAIN	USUBJID	FOCID	MASEQ	MASPID	MASTESTCD	MATEST	MAORRES	MASTRESC	MASPEC	MALAT	MADIR	MASEV
1	12345	MA	12345001	Injection site 1	1		GROSPATH	Gross Pathological Examination	Fur thin cover	Focal hair loss	SKIN	LEFT	DORSOCRANIAL
2	12345	MA	12345001	Injection site 2	2		GROSPATH	Gross Pathological Examination	Unremarkable	UNREMARKABLE	SKIN	RIGHT	DORSOCRANIAL
3	12345	MA	12345001	Injection site 3	3		GROSPATH	Gross Pathological Examination	Focal hemorrhage	Hemorrhage	SKIN	LEFT	DORSOCAUDAL
4	12345	MA	12345001	Injection site 4	4	MASS 1	GROSPATH	Gross Pathological Examination	Mass, approximately 8 mm long, 4 mm thick, pale firm well defined	Mass	SKIN	RIGHT	DORSOCAUDAL
5	12345	MA	12345002	Injection site 1	1		GROSPATH	Gross Pathological Examination	Unremarkable	UNREMARKABLE	SKIN	LEFT	DORSOCRANIAL
6	12345	MA	12345002	Injection site 2	2		GROSPATH	Gross Pathological Examination	Discoloration; subcutaneous; red; slight	Discoloration	SKIN	RIGHT	DORSOCRANIAL	MILD
7	12345	MA	12345002	Injection site 3	3		GROSPATH	Gross Pathological Examination	Unremarkable	UNREMARKABLE	SKIN	LEFT	DORSOCAUDAL
8	12345	MA	12345002	Injection site 4	4		GROSPATH	Gross Pathological Examination	Mucosal hemorrhage (about 2x2 cm), moderate	Hemorrhage	SKIN	RIGHT	DORSOCAUDAL	MODERATE

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Note that the concept of "MASS 1" (in CLSPID) is different from "Injection site 1" (in FOCID), in that information in the FOCID variable is known prior to the examination, but the mass ID/applicant identifier is assigned as part of the examination. FOCID thereby qualifies the test, whereas CLSPID qualifies the result.

cl.xpt

Row	STUDYID	DOMAIN	USUBJID	FOCID	CLSEQ	CLSPID	CLTESTCD	CLTEST	CLCAT	CLORRES	CLSTRESC	CLLOC	CLSEV	CLDTC	CLDY	CLNOMDY
1	12345	CL	12345001	Injection site 1	1		SKINEX	Skin Examination	CLINICAL SIGNS	Fur, Thin Cover; Left Scapula	Fur, Thin Cover	Left Scapula		2004-07-19	42	42
2	12345	CL	12345001	Injection site 2	2		SKINEX	Skin Examination	CLINICAL SIGNS	No Abnormal Findings, Right Scapula	Unremarkable	Right Scapula		2004-07-19	42	42
3	12345	CL	12345001	Injection site 3	3		SKINEX	Skin Examination	CLINICAL SIGNS	No Abnormal Findings, Left Medial Back	Unremarkable	Left Medial Back		2004-07-19	42	42
4	12345	CL	12345001	Injection site 4	4	MASS 1	SKINEX	Skin Examination	CLINICAL SIGNS	Moderate Swelling, Right Medial Back	Swelling	Right Medial Back	MODERATE	2004-07-19	42	42
5	12345	CL	12345002	Injection site 1	1		SKINEX	Skin Examination	CLINICAL SIGNS	No Abnormal Findings, Left Scapula	Unremarkable	Left Scapula		2004-07-19	42	42
6	12345	CL	12345002	Injection site 2	2		SKINEX	Skin Examination	CLINICAL SIGNS	Slight Reddening, Right Scapula	Reddening	Right Scapula	MILD	2004-07-19	42	42
7	12345	CL	12345002	Injection site 3	3		SKINEX	Skin Examination	CLINICAL SIGNS	Abrasion, Left Medial Back	Abrasion	Left Medial Back		2004-07-19	42	42
8	12345	CL	12345002	Injection site 4	4		SKINEX	Skin Examination	CLINICAL SIGNS	Moderate Reddening, Right Medial Back	Reddening	Right Medial Back	MODERATE	2004-07-19	42	42

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Macroscopic Findings (MA)