SEND Example.In vivo Pharmacokinetic Relationships 3

Only some records in PC used to calculate some parameters: Time points 8 and 9 on day 1 were not used for half-life calculations, but were used for other parameters.

Method A (Many to many, using PCGRPID and PPGRPID)

Day 8 relationships are the same as those shown in Example 1.

RELID 1	Indicates that all time points on Day 1 (PCGRPID = DY1_DRGX_A and DY1_DRGX_B) were used to calculate all parameters (PPGRPID = DY1DRGX_A) except half-lives.
RELID 2	Indicates only the values for PCGRPID = DY1_DRGX_A were used to calculate the half-lives (PPGRPID = DY1DRGX_HALF).

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relrec.xpt

Row	STUDYID	RDOMAIN	USUBJID	IDVAR	IDVARVAL	RELID
1	ABC-123	PC	ABC-123-0001	PCGRPID	DY1_DRGX_A	1
2	ABC-123	PC	ABC-123-0001	PCGRPID	DY1_DRGX_B	1
3	ABC-123	PP	ABC-123-0001	PPGRPID	DY1DRGX_A	1
4	ABC-123	PC	ABC-123-0001	PCGRPID	DY1_DRGX_A	2
5	ABC-123	PP	ABC-123-0001	PPGRPID	DY1DRGX_HALF	2

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Method B (One to many, using PCSEQ and PPGRPID)

Day 8 relationships are the same as those shown in Example 1.

RELID 1	Indicates records with PCSEQ values of 1-12 are related to records with PPGRPID = DY1DRGX_A
RELID 2	Indicates records with PCSEQ values of 1-7 and 10-12 are related to records with PPGRPID = DY1DRGX_HALF.

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relrec.xpt

Row	STUDYID	RDOMAIN	USUBJID	IDVAR	IDVARVAL	RELID
1	ABC-123	PC	ABC-123-0001	PCSEQ	1	1
2	ABC-123	PC	ABC-123-0001	PCSEQ	2	1
3	ABC-123	PC	ABC-123-0001	PCSEQ	3	1
4	ABC-123	PC	ABC-123-0001	PCSEQ	4	1
5	ABC-123	PC	ABC-123-0001	PCSEQ	5	1
6	ABC-123	PC	ABC-123-0001	PCSEQ	6	1
7	ABC-123	PC	ABC-123-0001	PCSEQ	7	1
8	ABC-123	PC	ABC-123-0001	PCSEQ	8	1
9	ABC-123	PC	ABC-123-0001	PCSEQ	9	1
10	ABC-123	PC	ABC-123-0001	PCSEQ	10	1
11	ABC-123	PC	ABC-123-0001	PCSEQ	11	1
12	ABC-123	PC	ABC-123-0001	PCSEQ	12	1
13	ABC-123	PP	ABC-123-0001	PPGRPID	DY1DRGX_A	1
14	ABC-123	PC	ABC-123-0001	PCSEQ	1	2
15	ABC-123	PC	ABC-123-0001	PCSEQ	2	2
16	ABC-123	PC	ABC-123-0001	PCSEQ	3	2
17	ABC-123	PC	ABC-123-0001	PCSEQ	4	2
18	ABC-123	PC	ABC-123-0001	PCSEQ	5	2
19	ABC-123	PC	ABC-123-0001	PCSEQ	6	2
20	ABC-123	PC	ABC-123-0001	PCSEQ	7	2
21	ABC-123	PC	ABC-123-0001	PCSEQ	10	2
22	ABC-123	PC	ABC-123-0001	PCSEQ	11	2
23	ABC-123	PC	ABC-123-0001	PCSEQ	12	2
24	ABC-123	PP	ABC-123-0001	PPGRPID	DY1DRGX_HALF	2

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Method C (Many to one, using PCGRPID and PPSEQ)

Day 8 relationships are the same as those shown in Example 1.

RELID 1	Indicates records with a PCGRPID value of DY1_DRGX_A and DY1_DRGX_B are related to records with PPSEQ values of 1-7.
RELID 2	Indicates records with a PCGRPID value of DY1_DRGX_A are related to records with PPSEQ values of 4 and 5.

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relrec.xpt

Row	STUDYID	RDOMAIN	USUBJID	IDVAR	IDVARVAL	RELID
1	ABC-123	PC	ABC-123-0001	PCGRPID	DY1_DRGX_A	1
2	ABC-123	PC	ABC-123-0001	PCGRPID	DY1_DRGX_B	1
3	ABC-123	PP	ABC-123-0001	PPSEQ	1	1
4	ABC-123	PP	ABC-123-0001	PPSEQ	2	1
5	ABC-123	PP	ABC-123-0001	PPSEQ	3	1
6	ABC-123	PP	ABC-123-0001	PPSEQ	6	1
7	ABC-123	PP	ABC-123-0001	PPSEQ	7	1
8	ABC-123	PC	ABC-123-0001	PCGRPID	DY1_DRGX_A	2
9	ABC-123	PP	ABC-123-0001	PPSEQ	4	2
10	ABC-123	PP	ABC-123-0001	PPSEQ	5	2

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Method D (One to one, using PCSEQ and PPSEQ)

Day 8 relationships are the same as those shown in Example 1.

RELID 1	Indicates records with PCSEQ values of 1-12 are related to records with PPSEQ values of 1-7.
RELID 2	Indicates records with PCSEQ values of 1-7 and 10-12 are related to records with PPSEQ values of 4 and 5.

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relrec.xpt

Row	STUDYID	RDOMAIN	USUBJID	IDVAR	IDVARVAL	RELID
1	ABC-123	PC	ABC-123-0001	PCSEQ	1	1
2	ABC-123	PC	ABC-123-0001	PCSEQ	2	1
3	ABC-123	PC	ABC-123-0001	PCSEQ	3	1
4	ABC-123	PC	ABC-123-0001	PCSEQ	4	1
5	ABC-123	PC	ABC-123-0001	PCSEQ	5	1
6	ABC-123	PC	ABC-123-0001	PCSEQ	6	1
7	ABC-123	PC	ABC-123-0001	PCSEQ	7	1
8	ABC-123	PC	ABC-123-0001	PCSEQ	8	1
9	ABC-123	PC	ABC-123-0001	PCSEQ	9	1
10	ABC-123	PC	ABC-123-0001	PCSEQ	10	1
11	ABC-123	PC	ABC-123-0001	PCSEQ	11	1
12	ABC-123	PC	ABC-123-0001	PCSEQ	12	1
13	ABC-123	PP	ABC-123-0001	PPSEQ	1	1
14	ABC-123	PP	ABC-123-0001	PPSEQ	2	1
15	ABC-123	PP	ABC-123-0001	PPSEQ	3	1
16	ABC-123	PP	ABC-123-0001	PPSEQ	6	1
17	ABC-123	PP	ABC-123-0001	PPSEQ	7	1
18	ABC-123	PC	ABC-123-0001	PCSEQ	1	2
19	ABC-123	PC	ABC-123-0001	PCSEQ	2	2
20	ABC-123	PC	ABC-123-0001	PCSEQ	3	2
21	ABC-123	PC	ABC-123-0001	PCSEQ	4	2
22	ABC-123	PC	ABC-123-0001	PCSEQ	5	2
23	ABC-123	PC	ABC-123-0001	PCSEQ	6	2
24	ABC-123	PC	ABC-123-0001	PCSEQ	7	2
25	ABC-123	PC	ABC-123-0001	PCSEQ	10	2
26	ABC-123	PC	ABC-123-0001	PCSEQ	11	2
27	ABC-123	PC	ABC-123-0001	PCSEQ	12	2
28	ABC-123	PP	ABC-123-0001	PPSEQ	4	2
29	ABC-123	PP	ABC-123-0001	PPSEQ	5	2

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SEND Example.In vivo Pharmacokinetic Relationships 3