See questions highlighted in red/orange.
- Is row 4 to delineate between 2D/3D/4D strain analysis LV chamber views? no
- Question for Jon Neville - does ANMETH fit for the place to put the chamber view ofr the MR visualization? - not the right analysis method. The analysis method is related to the intrinsic algorithm performed by the MRI/CMR machine. It is important to know what method was used. These are types of "Feature Tracking".
- Would it be better to show one segment across the different dimensional chamber views at 2 or 3 timepoints? 1, 2, 5 yr point - could do one with change and one without change. Whenever do an MRI - do this; all data can allow feature tracking strain
- Is there a best terminology to use for the dimensions? check CT, 2D, 3D, 4D OR two-dimensional, three-dimensional, four-dimensional (2D is peak radial strain; 3D is peak circumferential strain, 4D is peak longitudinal strain..... is "peak" assumed or does that need to be there?)- not out clinically, more experimentally.
- What test is used to measure fibrosis - is it LGE or strain? May use strain if you think may see... LGE is the answer. Strain is a marker of actual function. It worsens before the LVEF
- (normal - -18 to 20) - -9 is poor
- The LV Global is the average of base/mid/apex circumferential readings/values.
- Longitudinal strain normal is -18%
- LV Global Longitudinal strain is the average of LV 4, 3, 2 chamber readings/values
-20 is a good result, -10 is a poor result. Could show change over time with first assessment normal, one example could have poor 1 year follow-up and the other can have stable cardiomyopathy disease. Or could just do this.
Circumferential and Longitudinal Strain are CMR measurement parameters used to evaluate progression of cardiac dysfunction.
SME add relatsionship to DMD
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