"T1 mapping stands for registering the course of recovery of longitudinal magnetism", this means the relaxation time after either the preparation step (saturation or inversion prepulse) followed by the acquisition of images at several time points during the T1 recover/relaxation. T1 value represents the time when recovery of magnetism has reached a percentage of its original state (63%). The recovery rate relates to the myocardial tissue properties that may be altered by pathological tissue presence (https://www.ahajournals.org/doi/10.1161/circresaha.116.307974). T1 mapping values increase with disease, and decrease post contrast.
- What is the difference between T1 and T2? Should there be any differences in the data collected for each of these?
- Do we need minimum and maximum values? for SI mean, area, circumference, SI mean, SI min/max?
- Do we need timepoints for the T1 measurement or just the point in time of the final assessment?
- Does Cardiac Motion correction need to be indicated? If yes, does the type need to be indicated (such as the modified LL (MOLLI) sequence)? If yes, should this be reflected on each result? (Alana/Jon/Diane - I am considering a "Cardiac Motion Correction Indicator" NSV)
- Do we need a postcontrast indicator since those measurement differ? or is that what the terms "native T1" (no contrast) and "post-contrast T1" (after contrast) mean?
- Three is a "gold" standard noted as the "T1 mapping based on the acquisition of single images by a T1 turbo spin-echo sequence". It is noted as the ultimate T1 mapping method. Does the method need to be called out by what kind of acquisition sequence was used?
- For the location does the intracellular compartment need to be noted? (myocytes, fibroblasts, endothelial cells, smooth muscle cells)
- Does the cardiac phase for the specific T1 segment need to be noted? (atrial systole-diastole; isovolumentric contraction-diastole; rapid ejection-systole; reduced ejection-systole; isovolumetric relaxation-diastole; rapid ventricular filling-diastole)
- Is it important to record the "MRI scanner type" (Avanto, Siemens; Best, Philips; Acheiva, Philips), the "reception coil" (16-channel; 32-channel), "the T1 mapping sequence" (MOLLI; ShMOLLI)
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The following example shows the T1 mapping results for USUBJID 301. For brevity, after contrast only one of each test was shown in this example.
Rows 1-10: | Show the T1 Longitudinal Relaxation Time, the T2 Transverse Relaxation Time, Native T1 Mapping, and Extracellular volume for different segments of the heart prior to contrast for CMR. | Rows 11-14: | Show the T1 Longitudinal Relaxation Time, the T2 Transverse Relaxation Time, Native T1 Mapping, and Extracellular volume for different segments of the heart after contrast for CMR. |
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Row | STUDYID | DOMAIN | USUBJID | CVSEQ | CVTESTCD | CVTEST | CVCAT | CVORRES | CVORRESU | CVSTRESC | CVSTRESN | CVSTRESU | CVLOC | CVMETHOD | CVLOBFXL | VISITNUM | VISIT | CVDTC |
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| 1 | DMD-RT | CV | 301 | 1 | T1 | LONGITUDINAL RELAXATION TIME | | | ms | | 1315 | ms | LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 | | 2 | DMD-RT | CV | 301 | 2 | T1 | LONGITUDINAL RELAXATION TIME | Pre-contrast | 1166 | ms | 1166 | 1166 | ms | LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 | | 3 | DMD-RT | CV | 301 | 3 | T1 | LONGITUDINAL RELAXATION TIME | | | ms | | 980 | ms | LEFT VENTRICULAR BASAL INFERIOR SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 | | 4 | DMD-RT | CV | 301 | 4 | T2 | TRANSVERSE RELAXATION TIME | | | ms | | | ms | LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 | | 5 | DMD-RT | CV | 301 | 5 | T2 | TRANSVERSE RELAXATION TIME | | | ms | | | ms | LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 | | 6 | DMD-RT | CV | 301 | 6 | T2 | TRANSVERSE RELAXATION TIME | | | ms | | 985 | ms | LEFT VENTRICULAR BASAL INFERIOR SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 | | 7 | DMD-RT | CV | 301 | 7 |
| NATIVE T1 MAPPING | Pre-contrast | 1070 | ms | | 1070 | ms |
| CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 | | 8 | DMD-RT | CV | 301 | 8 | EXTRAVOL | EXTRACELLULAR VOLUME | | | /s | | 1.5 | /s | LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 | | 9 | DMD-RT | CV | 301 | 9 | EXTRAVOL | EXTRACELLULAR VOLUME | | | /s | | 1.2 | /s | LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 | | 10 | DMD-RT | CV | 301 | 10 | EXTRAVOL | EXTRACELLULAR VOLUME | | | /s | | 1.1 | /s | LEFT VENTRICULAR BASAL INFERIOR SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 | | 11 | DMD-RT | CV | 301 | 11 | T1 | LONGITUDINAL RELAXATION TIME | | | ms | | 1015 | ms | LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 | | 12 | DMD-RT | CV | 301 | 12 | T2 | TRANSVERSE RELAXATION TIME | | | ms | | | ms | LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 | | 13 | DMD-RT | CV | 301 | 13 |
| NATIVE T1 MAPPING | Post-contrast | 840 | ms | | 840 | ms |
| CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 | | 14 | DMD-RT | CV | 301 | 14 | EXTRAVOL | EXTRACELLULAR VOLUME | | | /s | | 1.1 | /s | LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 |
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The AG dataset shows the Gadolinium based contrast that was used for the procedure. In this example, the researchers did not collect the time of the contrast.
Row | STUDYID | DOMAIN | USUBJID | AGSEQ | AGTRT | AGCAT | AGDOSE | AGDOSU | AGDOSFRM | AGROUTE | AGSTDTC |
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1 | DMD-LGE | AG | 301 | 1 | Gd-DOTA | CONTRAST AGENT | 8 | mL | SOLUTION | INTRAVENOUS | 2023-08-01 |
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