Circumferential & Longitudinal Strain

Abnormal circumferential strain can be detected early in patients with DMD, despite the presence of normal ejection fraction. (Ref: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709409/) Regular cardiac function evaluations can lead to timely treatment which may slow the progression of cardiac fibrosis. (Ref: https://www.internationaljournalofcardiology.com/article/S0167-5273(23)00969-5/fulltext)

Example

This example shows the representation of circumferential and longitudinal strain findings in the CV domain. The sponsor used the "CMRBRANDTYP Feature Tracking" analysis method (CVANMETH).

Rows 1-3:	Show circumferential strain for the left ventricle base, mid, and apex regions.
Row 4:	Shows circumferential strain for the LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENT.
Row 5:	Shows global circumferential strain.
Rows 6-8:	Show longitudinal strain for 4 chamber, 3 chamber, and 2 chamber views.
Row 9:	Shows longitudinal strain for the LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENT.
Row 10:	Shows global longitudinal strain.

cv.xpt

Row	STUDYID	DOMAIN	USUBJID	CVSEQ	CVTESTCD	CVTEST	CVORRES	CVORRESU	CVSTRESC	CVSTRESN	CVSTRESU	CVLOC	CVMETHOD	CVANMETH	VISITNUM	VISIT	CVDTC	CVIMVIEW
1	DMD-CLS	CV	DMD-CLS-01-401	1	CFSTRAIN	Circumferential Strain	-9	%	-9	-9	%	HEART, LEFT VENTRICLE, BASE	MRI	CMRBRANDTYP Feature Tracking	1	VISIT 1	2023-09-01
2	DMD-CLS	CV	DMD-CLS-01-401	2	CFSTRAIN	Circumferential Strain	-12	%	-12	-12	%	HEART, LEFT VENTRICLE, MID	MRI	CMRBRANDTYP Feature tracking	1	VISIT 1	2023-09-01
3	DMD-CLS	CV	DMD-CLS-01-401	3	CFSTRAIN	Circumferential Strain	-10	%	-10	-10	%	HEART, LEFT VENTRICLE, APEX	MRI	CMRBRANDTYP Feature tracking	1	VISIT 1	2023-09-01
4	DMD-CLS	CV	DMD-CLS-01-401	4	CFSTRAIN	Circumferential Strain	-12	%	-12	-12	%	LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENT	MRI	CMRBRANDTYP Feature tracking	1	VISIT 1	2023-09-01
5	DMD-CLS	CV	DMD-CLS-01-401	5	GCS	Global Circumferential Strain	-10	%	-10	-10	%	HEART, LEFT VENTRICLE	MRI	CMRBRANDTYP Feature tracking	1	VISIT 1	2023-09-01
6	DMD-CLS	CV	DMD-CLS-01-401	6	LOSTRAIN	Longitudinal Strain	-18	%	-18	-18	%	HEART, LEFT VENTRICLE	MRI	CMRBRANDTYP Feature Tracking	1	VISIT 1	2023-09-01	4-CHAMBER
7	DMD-CLS	CV	DMD-CLS-01-401	7	LOSTRAIN	Longitudinal Strain	-20	%	-20	-20	%	HEART, LEFT VENTRICLE	MRI	CMRBRANDTYP Feature tracking	1	VISIT 1	2023-09-01	3-CHAMBER
8	DMD-CLS	CV	DMD-CLS-01-401	8	LOSTRAIN	Longitudinal Strain	-15	%	-15	-15	%	HEART, LEFT VENTRICLE	MRI	CMRBRANDTYP Feature tracking	1	VISIT 1	2023-09-01	2-CHAMBER
9	DMD-CLS	CV	DMD-CLS-01-401	9	LOSTRAIN	Longitudinal Strain	-14	%	-14	-14	%	LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENT	MRI	CMRBRANDTYP Feature tracking	1	VISIT 1	2023-09-01
10	DMD-CLS	CV	DMD-CLS-01-401	10	LGS	Global Longitudinal Strain	-18	%	-18	-18	%	HEART, LEFT VENTRICLE	MRI	CMRBRANDTYP Feature tracking	1	VISIT 1	2023-09-01

$warningHtml

CV NSV Metadata

Variable	Label	Type	Role	Origin
CVIMVIEW	Imaging View	text	Non-standard Record Qualifier	CRF

Dataset Wrapper Debug Message

Please add a row column to your dataset.

For more information on the domains used in this section see:

Cardiovascular System Findings (CV) - SDTMIG v3.4, Section 6.3.7.2

Space shortcuts

Page tree