HLA Genotyping

This example is currently in draft.

This example shows findings from an assessment of the unique pattern of allelic variation in genes of human leukocyte antigens (HLA), for purposes such as selecting cell, tissue and organ donors, diagnosing autoimmune diseases, determining the risk of adverse drug reactions, or to guide immunotherapies. An arbitrary identifier for the allele is represented in GFCOPYID. Patterns of HLA allele sequences are reported as short codes from a publicly available reference database.

Rows 1-9, 11, 15-16:	Show the characterization of the unique pattern of sequence variation for the allele of the HLA gene of interest represented in GFSYM.
Rows 10, 12-14:	Show attempted assessments for which results could not be generated due to sequence overlap with the detected DRB1 allele.

gf.xpt

Row	STUDYID	DOMAIN	USUBJID	GFSEQ	GFREFID	GFTESTCD	GFTEST	GFTSTDTL	GFORRES	GFSYM	GFSYMTYP	GFCOPYID	GFSTAT	GFREASND	GFNAM	GFSPEC	GFMETHOD	VISITNUM	VISIT	VISITDY	GFDTC	GFDY
1	Study-123	GF	S123-001	1	HGA4567	VARPROF	Variant Profile	ALLELE TYPE	A*02:TSXZ	HLA-A	GENE WITH PROTEIN PRODUCT	1			ACME Genomics	DNA	SANGER SEQUENCING	-1	SCREENING	-1	9/16/2023	-2
2	Study-123	GF	S123-001	1	HGA4567	VARPROF	Variant Profile	ALLELE TYPE	A*03:ABSAX	HLA-A	GENE WITH PROTEIN PRODUCT	2			ACME Genomics	DNA	SANGER SEQUENCING
3	Study-123	GF	S123-001	1	HGA4567	VARPROF	Variant Profile	ALLELE TYPE	B*18:TXYF	HLA-B	GENE WITH PROTEIN PRODUCT	1			ACME Genomics	DNA	SANGER SEQUENCING
4	Study-123	GF	S123-001	1	HGA4567	VARPROF	Variant Profile	ALLELE TYPE	B*38:01	HLA-B	GENE WITH PROTEIN PRODUCT	2			ACME Genomics	DNA	SANGER SEQUENCING
5	Study-123	GF	S123-001	1	HGA4567	VARPROF	Variant Profile	ALLELE TYPE	C*07:AAEPN	HLA-C	GENE WITH PROTEIN PRODUCT	1			ACME Genomics	DNA	SANGER SEQUENCING
6	Study-123	GF	S123-001	1	HGA4567	VARPROF	Variant Profile	ALLELE TYPE	C*12:AAGWE	HLA-C	GENE WITH PROTEIN PRODUCT	2			ACME Genomics	DNA	SANGER SEQUENCING
6	Study-123	GF	S123-001	1	HGA4567	VARPROF	Variant Profile	ALLELE TYPE	DRB1*07:ACEUA	HLA-DRB1	GENE WITH PROTEIN PRODUCT	1			ACME Genomics	DNA	SANGER SEQUENCING
7	Study-123	GF	S123-001	1	HGA4567	VARPROF	Variant Profile	ALLELE TYPE	DRB1*14:ABZZV	HLA-DRB1	GENE WITH PROTEIN PRODUCT	2			ACME Genomics	DNA	SANGER SEQUENCING
9	Study-123	GF	S123-001	1	HGA4567	VARPROF	Variant Profile	ALLELE TYPE	DRB3*01:XX	HLA-DRB3	GENE WITH PROTEIN PRODUCT	1			ACME Genomics	DNA	SANGER SEQUENCING
10	Study-123	GF	S123-001	1	HGA4567	VARPROF	Variant Profile	ALLELE TYPE		HLA-DRB3	GENE WITH PROTEIN PRODUCT	2	NOT DONE	DRB3*	ACME Genomics	DNA	SANGER SEQUENCING
11	Study-123	GF	S123-001	1	HGA4567	VARPROF	Variant Profile	ALLELE TYPE	DRB4*01:FVUU	HLA-DRB4	GENE WITH PROTEIN PRODUCT	1			ACME Genomics	DNA	SANGER SEQUENCING
12	Study-123	GF	S123-001	1	HGA4567	VARPROF	Variant Profile	ALLELE TYPE		HLA-DRB4	GENE WITH PROTEIN PRODUCT	2	NOT DONE	DRB4*	ACME Genomics	DNA	SANGER SEQUENCING
13	Study-123	GF	S123-001	1	HGA4567	VARPROF	Variant Profile	ALLELE TYPE		HLA-DRB5	GENE WITH PROTEIN PRODUCT	1	NOT DONE	DRB5*	ACME Genomics	DNA	SANGER SEQUENCING
14	Study-123	GF	S123-001	1	HGA4567	VARPROF	Variant Profile	ALLELE TYPE		HLA-DRB5	GENE WITH PROTEIN PRODUCT	2	NOT DONE	DRB5*	ACME Genomics	DNA	SANGER SEQUENCING
15	Study-123	GF	S123-001	1	HGA4567	VARPROF	Variant Profile	ALLELE TYPE	DQB1*02:ACBXN	HLA-DQB1	GENE WITH PROTEIN PRODUCT	1			ACME Genomics	DNA	SANGER SEQUENCING
16	Study-123	GF	S123-001	1	HGA4567	VARPROF	Variant Profile	ALLELE TYPE	DQB1*05:ACEDB	HLA-DQB1	GENE WITH PROTEIN PRODUCT	2			ACME Genomics	DNA	SANGER SEQUENCING

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HLA Genotyping