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(SMEs add content and update the text below. Thank you.)

Parametric Mapping is a way to measure relaxation time for longitudinal and transverse relaxation time along with extracellular volume.

"T1 mapping stands for registering the course of recovery of longitudinal magnetism", this means the relaxation time after either the preparation step (saturation or inversion prepulse) followed by the acquisition of images at several time points during the T1 recover/relaxation. T1 value represents the time when recovery of magnetism has reached a percentage of its original state (63%). The recovery rate relates to the myocardial tissue properties that may be altered by pathological tissue presence (https://www.ahajournals.org/doi/10.1161/circresaha.116.307974). T1 mapping values increase with disease, and decrease post contrast.

  1. What is the difference between T1 and T2? Should there be any differences in the data collected for each of these? one is longitudinal relaxation time and the other is transverse relaxation time.  The results vary by the physics of the MRI. It shows how the protocns relax after a period of excitation. 1.5 Tesla has a different constant than for another type of scanner. It detects edema/fibrosis.  Transverse relaxation time - under 49 change to 40 to 50; 50,60 is high.
  2. Do we need minimum and maximum values? for SI mean, area, circumference, SI mean, SI min/max?- will change depending on the (also changes after contrast)- NA; in the context of research do they collect this - no. Not relevant.
  3. For extracellular volume - use percent. Normal is under 28.5%; Abnormal is in the mid 30%; mid 20% 

  4. Post contrast longitudinal relaxation time is 400s to 500s

  5. Post contrast transverse relaxation time is not done


Stopped here -

  1. Do we need timepoints for the T1 measurement or just the point in time of the final assessment?
  2. Does Cardiac Motion correction need to be indicated? If yes, does the type need to be indicated (such as the modified LL (MOLLI) sequence)?  If yes, should this be reflected on each result? (Alana/Jon/Diane - I am considering a "Cardiac Motion Correction Indicator" NSV if this is important)
  3. Do we need a postcontrast indicator since those measurement differ? or is that what the terms "native T1" (no contrast) and "post-contrast T1" (after contrast) mean?
  4. Three is a "gold" standard noted as the "T1 mapping based on the acquisition of single images by a T1 turbo spin-echo sequence". It is noted as the ultimate T1 mapping method. Does the method need to be called out by what kind of acquisition sequence was used?
  5. For the location does the intracellular compartment need to be noted? (myocytes, fibroblasts, endothelial cells, smooth muscle cells)
  6. Does the cardiac phase for the specific T1 segment need to be noted? (atrial systole-diastole; isovolumentric contraction-diastole; rapid ejection-systole; reduced ejection-systole; isovolumetric relaxation-diastole; rapid ventricular filling-diastole)
  7. Is it important to record the "MRI scanner type" (Avanto, Siemens; Best, Philips; Acheiva, Philips), the "reception coil" (16-channel; 32-channel), "the T1 mapping sequence" (MOLLI; ShMOLLI)

The following example shows the parametric mapping (T1 mapping, T2 mapping, and extracellular volume) results for USUBJID 301. For brevity, after contrast a limited sample of tests were shown in this example.


The PR dataset shows the procedure of cardiac magnetic resonance imaging using the device associated with SPDEVID ABC001 and the PRREFID of 12345678. This information shows what CMR device is used for the procedure and the accession number or procedure reference identifier associated with the specific procedure for USUBJID 301. The SPDEVID variable is used to relate records by the device (in this case, the CMR machine). The Device Identifier (DI) dataset holds the device information details.

pr.xpt

pr.xpt

Row

STUDYID

DOMAIN

USUBJID

SPDEVID

PRSEQ

PRREFID

PRLNKID

PRTRT

PRSTDTC

1

DMD-RT

PR

301

ABC001

1

12345678

04

CARDIAC MAGNETIC RESONANCE IMAGING

2023-08-01

$warningHtml
The Cardiovascular System Findings (CV) dataset contains physiological and morphological findings related to the cardiovascular system so it holds the assessments from the parametric mapping. The CV dataset below shows how to represent longitudinal relaxation time, transverse relaxation time and extracellular volume findings from CMR.


Rows 1-10:Show the T1 Longitudinal Relaxation Time, the T2 Transverse Relaxation Time, Native T1 Mapping, and Extracellular volume for different segments of the heart prior to contrast for CMR.
Rows 11-13:Show the T1 Longitudinal Relaxation Time, Native T1 Mapping, and Extracellular volume for different segments of the heart after contrast for CMR.

cv.xpt

cv.xpt

Row

STUDYID

DOMAIN

USUBJID

CVSEQ

CVTESTCD

CVTEST

CVCAT

CVORRES

CVORRESU

CVSTRESC

CVSTRESN

CVSTRESU

CVSTAT

CVREASND

CVLOC

CVMETHOD

CVLOBFXL

VISITNUM

VISIT

CVDTC


CVICNOIS

CVICMOTD

CVFOIIND

CVOIQ

1DMD-RTCV3011T1LONGITUDINAL RELAXATION TIME

Pre-contrast

1315

ms

1315

1315ms



LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT

CARDIAC MAGNETIC RESONANCE IMAGING
1SCREENING2023-08-01
LOW NOISENO MOTION DISTORTIONNO FOREIGN OBJECTSEVALUABLE IMAGE
2DMD-RTCV3012T1LONGITUDINAL RELAXATION TIMEPre-contrast1166ms11661166ms

LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENTCARDIAC MAGNETIC RESONANCE IMAGING
1SCREENING2023-08-01
LOW NOISENO MOTION DISTORTIONNO FOREIGN OBJECTSEVALUABLE IMAGE
3DMD-RTCV3013T1LONGITUDINAL RELAXATION TIME

Pre-contrast

980

ms

980

980ms

LEFT VENTRICULAR BASAL INFERIOR SEGMENTCARDIAC MAGNETIC RESONANCE IMAGING
1SCREENING2023-08-01
LOW NOISENO MOTION DISTORTIONNO FOREIGN OBJECTSEVALUABLE IMAGE
4DMD-RTCV3014T2TRANSVERSE RELAXATION TIME

Pre-contrast

45

ms4545ms



LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT

CARDIAC MAGNETIC RESONANCE IMAGING
1SCREENING2023-08-01
LOW NOISENO MOTION DISTORTIONNO FOREIGN OBJECTSEVALUABLE IMAGE
5DMD-RTCV3015T2TRANSVERSE RELAXATION TIME

Pre-contrast

40

ms4040ms

LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENTCARDIAC MAGNETIC RESONANCE IMAGING
1SCREENING2023-08-01
LOW NOISENO MOTION DISTORTIONNO FOREIGN OBJECTSEVALUABLE IMAGE
6DMD-RTCV3016T2TRANSVERSE RELAXATION TIME

Pre-contrast

48

ms4848ms

LEFT VENTRICULAR BASAL INFERIOR SEGMENTCARDIAC MAGNETIC RESONANCE IMAGING
1SCREENING2023-08-01
LOW NOISENO MOTION DISTORTIONNO FOREIGN OBJECTSEVALUABLE IMAGE
7DMD-RTCV3017
NATIVE T1 MAPPINGPre-contrast1070ms

1070

1070ms


CARDIAC MAGNETIC RESONANCE IMAGING
1SCREENING2023-08-01
LOW NOISENO MOTION DISTORTIONNO FOREIGN OBJECTSNON-EVALUABLE IMAGE
8DMD-RTCV3018EXTRAVOLEXTRACELLULAR VOLUME

Pre-contrast

1.5

/s

1.5

1.5/s



LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT

CARDIAC MAGNETIC RESONANCE IMAGING
1SCREENING2023-08-01
LOW NOISENO MOTION DISTORTIONNO FOREIGN OBJECTSEVALUABLE IMAGE
9DMD-RTCV3019EXTRAVOLEXTRACELLULAR VOLUME

Pre-contrast

1.2

/s

1.2

1.2/s

LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENTCARDIAC MAGNETIC RESONANCE IMAGING
1SCREENING2023-08-01
LOW NOISENO MOTION DISTORTIONNO FOREIGN OBJECTSEVALUABLE IMAGE
10DMD-RTCV30110EXTRAVOLEXTRACELLULAR VOLUME

Pre-contrast

1.1

/s

1.1

1.1/s

LEFT VENTRICULAR BASAL INFERIOR SEGMENTCARDIAC MAGNETIC RESONANCE IMAGING
1SCREENING2023-08-01
LOW NOISENO MOTION DISTORTIONNO FOREIGN OBJECTSEVALUABLE IMAGE
11DMD-RTCV30111T1LONGITUDINAL RELAXATION TIME

Post-contrast

450

ms450450ms



LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT

CARDIAC MAGNETIC RESONANCE IMAGING
1SCREENING2023-08-01
LOW NOISENO MOTION DISTORTIONNO FOREIGN OBJECTSEVALUABLE IMAGE
12DMD-RTCV30112
NATIVE T1 MAPPINGPost-contrast840ms

840

840ms


CARDIAC MAGNETIC RESONANCE IMAGING
1SCREENING2023-08-01
LOW NOISENO MOTION DISTORTIONNO FOREIGN OBJECTSEVALUABLE IMAGE
13DMD-RTCV30113EXTRAVOLEXTRACELLULAR VOLUME

Post-contrast

25

%2525%



LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT

CARDIAC MAGNETIC RESONANCE IMAGING
1SCREENING2023-08-01
LOW NOISENO MOTION DISTORTIONNO FOREIGN OBJECTSEVALUABLE IMAGE
1DMD-RTCV3021CVALLCMR TEST RESULTS







NOT DONE

NON-EVALUABLE IMAGE

HEART

CARDIAC MAGNETIC RESONANCE IMAGING
1SCREENING2023-08-05
HIGH NOISEYES-NOT ACCEPTABLE MOTION DISTORTIONYES FOREIGN OBJECTSNON-EVALUABLE IMAGE
$warningHtml

CV NSV Metadata

Dataset Wrapper Debug Message

Please add a row column to your dataset.

The AG dataset shows the Gadolinium based contrast that was used for the procedure. In this example, the researchers did not collect the time of the contrast.

ag.xpt

ag.xpt

Row

STUDYID

DOMAIN

USUBJID

AGSEQ

AGTRT

AGCAT

AGDOSE

AGDOSU

AGDOSFRM

AGROUTE

AGSTDTC

1

DMD-LGE

AG

301

1

Gd-DOTA

CONTRAST AGENT

8

mL

SOLUTION

INTRAVENOUS

2023-08-01

$warningHtml
DI holds the device identifier information that describes the device used to produce the image that was the basis of the interpretation recorded in the CV domain. Characteristics in DI are those necessary to identify each device to the level of granularity necessary for the study (e.g., to the model level if knowing the actual unit is not necessary, to the serial number level if there is a need to distinguish among units).

di.xpt

di.xpt

Row

STUDYID

DOMAIN

SPDEVID

DISEQ

DIPARMCD

DIPARM

DIVAL

1

DMD-LGE

DI

ABC001

1

DEVTYPE

Device Type

CMR Scanner

2

DMD-LGE

DI

ABC001

2

MANUF

Manufacturer

ACME

3

DMD-LGE

DI

ABC001

3

TRADENAM

Trade Name

ACME 64

4

DMD-LGE

DI

ABC001

4

MODEL

Model Number

CMR540

$warningHtml
Fixed properties of devices identified in DI are represented in the DO domain. The sponsor chose to keep the software version constant throughout the study. DO should contain properties that are important for interpreting the data. 

do.xpt

do.xpt

Row

STUDYID

DOMAIN

SPDEVID

DOSEQ

DOTESTCD

DOTEST

DOORRES

DOORRESU

1

DMD-LGE

DO

ABC002

1

SFTWRNAM

Software Name

CMRRLXU2


2

DMD-LGE

DO

ABC002

2

SFTWRVER

Software Version

CMRLX.2


3

DMD-LGE

DO

ABC002

3IMAQDIMImage Acquisition Dimensionality3
$warningHtml
Changeable properties and parameters of the devices identified in DI are represented in the DU domain. These settings could be linked to the record in the CV domain by their shared SPDEVID and DTC values. For the sake of brevity, only 1 subject's parameters are shown. For more information on relating records, see SDTMIG v3.4 Section 8.2, Relating Peer Records. 


Notes for discussion

Interslice Distance - aligns with "Gap"

A minimum of 12 slices were performed, with 20 phases/slice... ?

Imaging protocol - would this be put somewhere? It seems like it would be helpful - would a GRPID be used and then defined somewhere? Or, would it be in the study protocol and not required in the data. If aggregating across studies, it seems like it would be helpful to have it in the data.

Number of excitations =2 for breath hold; 4 to 5 for free breathing (what would this DUTEST be?)

Radiofrequency flip angles were set between 50 degrees and 70 degrees

Grid tag spacing was 7 to 8 mm

TE/TR = 3ms/6.6 ms (by type of machiine)

views per segment = views/segment = 7 to 9  based on machine type (one was = 8)


Data analysis was via "standard planimetry techniques" using semi-automated computer software - this is where Medis is mentioned... is this perhaps what should be in ANMETH?  Do we have a definition for "Feature Tracking" (in the Circum and Long Strain examples)


https://www.jacc.org/doi/abs/10.1016/j.jacc.2008.12.032 - article is for strain - find one for CMR and Parametric mapping .... if different parameters.




du.xpt

du.xpt

Row

STUDYID

DOMAIN

USUBJID

SPDEVID

DUSEQ

DUREFID

DUTESTCD

DUTEST

DUORRES

DUORRESU

DUSTRESC

DUSTRESN

DUSTRESU

DUDTC

1

DMD-LGE

DU

301

ABC001

1

12345678

FLIPANGLFlip Angle50deg5050deg

2023-08-01

2

DMD-LGE

DU

301

ABC001

2

12345678

INTDISTM

Interslice Distance

1mm11mm

2023-08-01

3

DMD-LGE

DU

301

ABC001

3

12345678

STHICKSlice Thickness6mm66mm

2023-08-01

4

DMD-LGE

DU

301

ABC001

7

12345678

FLDVIEWField of View32X38cm32X3832X38cm

2023-08-01

5

DMD-LGE

DU

301

ABC001

8

12345678

NUMSLICENumber of Slices12
1212

2023-08-01

Dataset Debug Messages

The RELREC dataset is used to describe the relationship between 2 or more records in different domains. For more information on relating records see SDTMIG v3.4, Section 8.2.
$titleHtml

relrec.xpt

Row

STUDYID

RDOMAIN

USUBJID

IDVAR

IDVARVAL

RELTYPE

RELID

1

DMD-LGE

PR


PRLNKID


ONE

04

2

DMD-LGE

CV


CVLNKID


MANY

04

3

DMD-LGE

AG


AGLNKID


ONE

04

$warningHtml

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