(SMEs add content and update the text below. Thank you.)
Parametric Mapping is a way to measure relaxation time for longitudinal and transverse relaxation time along with extracellular volume.
"T1 mapping stands for registering the course of recovery of longitudinal magnetism", this means the relaxation time after either the preparation step (saturation or inversion prepulse) followed by the acquisition of images at several time points during the T1 recover/relaxation. T1 value represents the time when recovery of magnetism has reached a percentage of its original state (63%). The recovery rate relates to the myocardial tissue properties that may be altered by pathological tissue presence (https://www.ahajournals.org/doi/10.1161/circresaha.116.307974). T1 mapping values increase with disease, and decrease post contrast.
What is the difference between T1 and T2? Should there be any differences in the data collected for each of these? one is longitudinal relaxation time and the other is transverse relaxation time. The results vary by the physics of the MRI. It shows how the protocns relax after a period of excitation. 1.5 Tesla has a different constant than for another type of scanner. It detects edema/fibrosis. Transverse relaxation time - under 49 change to 40 to 50; 50,60 is high.
Do we need minimum and maximum values? for SI mean, area, circumference, SI mean, SI min/max?- will change depending on the (also changes after contrast)- NA; in the context of research do they collect this - no. Not relevant.
For extracellular volume - use percent. Normal is under 28.5%; Abnormal is in the mid 30%; mid 20%
Post contrast longitudinal relaxation time is 400s to 500s
Post contrast transverse relaxation time is not done
Stopped here -
Do we need timepoints for the T1 measurement or just the point in time of the final assessment?
Does Cardiac Motion correction need to be indicated? If yes, does the type need to be indicated (such as the modified LL (MOLLI) sequence)? If yes, should this be reflected on each result? (Alana/Jon/Diane - I am considering a "Cardiac Motion Correction Indicator" NSV)
Do we need a postcontrast indicator since those measurement differ? or is that what the terms "native T1" (no contrast) and "post-contrast T1" (after contrast) mean?
Three is a "gold" standard noted as the "T1 mapping based on the acquisition of single images by a T1 turbo spin-echo sequence". It is noted as the ultimate T1 mapping method. Does the method need to be called out by what kind of acquisition sequence was used?
For the location does the intracellular compartment need to be noted? (myocytes, fibroblasts, endothelial cells, smooth muscle cells)
Does the cardiac phase for the specific T1 segment need to be noted? (atrial systole-diastole; isovolumentric contraction-diastole; rapid ejection-systole; reduced ejection-systole; isovolumetric relaxation-diastole; rapid ventricular filling-diastole)
Is it important to record the "MRI scanner type" (Avanto, Siemens; Best, Philips; Acheiva, Philips), the "reception coil" (16-channel; 32-channel), "the T1 mapping sequence" (MOLLI; ShMOLLI)
The following example shows the parametric mapping (T1 mapping, T2 mapping, and extracellular volume) results for USUBJID 301. For brevity, after contrast a limited sample of tests were shown in this example.
The PR dataset shows the procedure of cardiac magnetic resonance imaging using the device associated with SPDEVID ABC001 and the PRREFID of 12345678. This information shows what CMR device is used for the procedure and the accession number or procedure reference identifier associated with the specific procedure for USUBJID 301. The SPDEVID variable is used to relate records by the device (in this case, the CMR machine).
pr.xpt
pr.xpt
Row
STUDYID
DOMAIN
USUBJID
SPDEVID
PRSEQ
PRREFID
PRLNKID
PRTRT
PRSTDTC
1
DMD-RT
PR
301
ABC001
1
12345678
04
CARDIAC MAGNETIC RESONANCE IMAGING
2023-08-01
$warningHtml
Rows 1-10:
Show the T1 Longitudinal Relaxation Time, the T2 Transverse Relaxation Time, Native T1 Mapping, and Extracellular volume for different segments of the heart prior to contrast for CMR.
Rows 11-13:
Show the T1 Longitudinal Relaxation Time, Native T1 Mapping, and Extracellular volume for different segments of the heart after contrast for CMR.
cv.xpt
cv.xpt
Row
STUDYID
DOMAIN
USUBJID
CVSEQ
CVTESTCD
CVTEST
CVCAT
CVORRES
CVORRESU
CVSTRESC
CVSTRESN
CVSTRESU
CVSTAT
CVREASND
CVLOC
CVMETHOD
CVLOBFXL
VISITNUM
VISIT
CVDTC
CVICNOIS
CVICMOTD
CVFOIND
CVOIQ
1
DMD-RT
CV
301
1
T1
LONGITUDINAL RELAXATION TIME
Pre-contrast
1315
ms
1315
1315
ms
LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT
CARDIAC MAGNETIC RESONANCE IMAGING
1
SCREENING
2023-08-01
LOW NOISE
NO MOTION DISTORTION
NO FOREIGN OBJECTS
EVALUABLE IMAGE
2
DMD-RT
CV
301
2
T1
LONGITUDINAL RELAXATION TIME
Pre-contrast
1166
ms
1166
1166
ms
LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENT
CARDIAC MAGNETIC RESONANCE IMAGING
1
SCREENING
2023-08-01
LOW NOISE
NO MOTION DISTORTION
NO FOREIGN OBJECTS
EVALUABLE IMAGE
3
DMD-RT
CV
301
3
T1
LONGITUDINAL RELAXATION TIME
Pre-contrast
980
ms
980
980
ms
LEFT VENTRICULAR BASAL INFERIOR SEGMENT
CARDIAC MAGNETIC RESONANCE IMAGING
1
SCREENING
2023-08-01
LOW NOISE
NO MOTION DISTORTION
NO FOREIGN OBJECTS
EVALUABLE IMAGE
4
DMD-RT
CV
301
4
T2
TRANSVERSE RELAXATION TIME
Pre-contrast
45
ms
45
45
ms
LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT
CARDIAC MAGNETIC RESONANCE IMAGING
1
SCREENING
2023-08-01
LOW NOISE
NO MOTION DISTORTION
NO FOREIGN OBJECTS
EVALUABLE IMAGE
5
DMD-RT
CV
301
5
T2
TRANSVERSE RELAXATION TIME
Pre-contrast
40
ms
40
40
ms
LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENT
CARDIAC MAGNETIC RESONANCE IMAGING
1
SCREENING
2023-08-01
LOW NOISE
NO MOTION DISTORTION
NO FOREIGN OBJECTS
EVALUABLE IMAGE
6
DMD-RT
CV
301
6
T2
TRANSVERSE RELAXATION TIME
Pre-contrast
48
ms
48
48
ms
LEFT VENTRICULAR BASAL INFERIOR SEGMENT
CARDIAC MAGNETIC RESONANCE IMAGING
1
SCREENING
2023-08-01
LOW NOISE
NO MOTION DISTORTION
NO FOREIGN OBJECTS
EVALUABLE IMAGE
7
DMD-RT
CV
301
7
NATIVE T1 MAPPING
Pre-contrast
1070
ms
1070
1070
ms
CARDIAC MAGNETIC RESONANCE IMAGING
1
SCREENING
2023-08-01
LOW NOISE
NO MOTION DISTORTION
NO FOREIGN OBJECTS
NON-EVALUABLE IMAGE
8
DMD-RT
CV
301
8
EXTRAVOL
EXTRACELLULAR VOLUME
Pre-contrast
1.5
/s
1.5
1.5
/s
LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT
CARDIAC MAGNETIC RESONANCE IMAGING
1
SCREENING
2023-08-01
LOW NOISE
NO MOTION DISTORTION
NO FOREIGN OBJECTS
EVALUABLE IMAGE
9
DMD-RT
CV
301
9
EXTRAVOL
EXTRACELLULAR VOLUME
Pre-contrast
1.2
/s
1.2
1.2
/s
LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENT
CARDIAC MAGNETIC RESONANCE IMAGING
1
SCREENING
2023-08-01
LOW NOISE
NO MOTION DISTORTION
NO FOREIGN OBJECTS
EVALUABLE IMAGE
10
DMD-RT
CV
301
10
EXTRAVOL
EXTRACELLULAR VOLUME
Pre-contrast
1.1
/s
1.1
1.1
/s
LEFT VENTRICULAR BASAL INFERIOR SEGMENT
CARDIAC MAGNETIC RESONANCE IMAGING
1
SCREENING
2023-08-01
LOW NOISE
NO MOTION DISTORTION
NO FOREIGN OBJECTS
EVALUABLE IMAGE
11
DMD-RT
CV
301
11
T1
LONGITUDINAL RELAXATION TIME
Post-contrast
450
ms
450
450
ms
LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT
CARDIAC MAGNETIC RESONANCE IMAGING
1
SCREENING
2023-08-01
LOW NOISE
NO MOTION DISTORTION
NO FOREIGN OBJECTS
EVALUABLE IMAGE
12
DMD-RT
CV
301
12
NATIVE T1 MAPPING
Post-contrast
840
ms
840
840
ms
CARDIAC MAGNETIC RESONANCE IMAGING
1
SCREENING
2023-08-01
LOW NOISE
NO MOTION DISTORTION
NO FOREIGN OBJECTS
EVALUABLE IMAGE
13
DMD-RT
CV
301
13
EXTRAVOL
EXTRACELLULAR VOLUME
Post-contrast
25
%
25
25
%
LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT
CARDIAC MAGNETIC RESONANCE IMAGING
1
SCREENING
2023-08-01
LOW NOISE
NO MOTION DISTORTION
NO FOREIGN OBJECTS
EVALUABLE IMAGE
1
DMD-RT
CV
302
1
CVALL
CMR TEST RESULTS
NOT DONE
NON-EVALUABLE IMAGE
HEART
CARDIAC MAGNETIC RESONANCE IMAGING
1
SCREENING
2023-08-05
HIGH NOISE
YES-NOT ACCEPTABLE MOTION DISTORTION
YES FOREIGN OBJECTS
NON-EVALUABLE IMAGE
$warningHtml
CV NSV Metadata
Variable
Label
Type
Role
Origin
CVICNOIS
Image Condition r/t Noise
text
Non-standard Record Qualifier
CRF
CVICMOTD
Image Condition r/t Motion Distortion
text
Non-standard Record Qualifier
CRF
CVFOIIND
Foreign Object on Image Indicator
text
Non-standard Record Qualifier
CRF
CVOIQ
Overall Image Quality
text
Non-standard Record Qualifier
CRF
Dataset Wrapper Debug Message
Please add a row column to your dataset.
The AG dataset shows the Gadolinium based contrast that was used for the procedure. In this example, the researchers did not collect the time of the contrast.
ag.xpt
ag.xpt
Row
STUDYID
DOMAIN
USUBJID
AGSEQ
AGTRT
AGCAT
AGDOSE
AGDOSU
AGDOSFRM
AGROUTE
AGSTDTC
1
DMD-LGE
AG
301
1
Gd-DOTA
CONTRAST AGENT
8
mL
SOLUTION
INTRAVENOUS
2023-08-01
$warningHtml
DI holds the device identifier information that describes the device used to produce the image that was the basis of the interpretation recorded in the CV domain. Characteristics in DI are those necessary to identify each device to the level of granularity necessary for the study (e.g., to the model level if knowing the actual unit is not necessary, to the serial number level if there is a need to distinguish among units).
di.xpt
di.xpt
Row
STUDYID
DOMAIN
SPDEVID
DISEQ
DIPARMCD
DIPARM
DIVAL
1
DMD-LGE
DI
ABC001
1
DEVTYPE
Device Type
CMR Scanner
2
DMD-LGE
DI
ABC001
2
MANUF
Manufacturer
ACME
3
DMD-LGE
DI
ABC001
3
TRADENAM
Trade Name
ACME 64
4
DMD-LGE
DI
ABC001
4
MODEL
Model Number
CMR540
$warningHtml
Fixed properties of devices identified in DI are represented in the DO domain. The sponsor chose to keep the software version constant throughout the study. DO should contain properties that are important for interpreting the data.
do.xpt
do.xpt
Row
STUDYID
DOMAIN
SPDEVID
DOSEQ
DOTESTCD
DOTEST
DOORRES
DOORRESU
1
DMD-LGE
DO
ABC002
1
SFTWRNAM
Software Name
CMRRLXU2
2
DMD-LGE
DO
ABC002
2
SFTWRVER
Software Version
CMRLX.2
3
DMD-LGE
DO
ABC002
3
IMAQDIM
Image Acquisition Dimensionality
3
$warningHtml
Changeable properties and parameters of the devices identified in DI are represented in the DU domain. These settings could be linked to the record in the CV domain by their shared SPDEVID and DTC values. For the sake of brevity, only 1 subject's parameters are shown. For more information on relating records, see SDTMIG v3.4 Section 8.2, Relating Peer Records.
du.xpt
du.xpt
Row
STUDYID
DOMAIN
USUBJID
SPDEVID
DUSEQ
DUREFID
DUTESTCD
DUTEST
DUORRES
DUORRESU
DUSTRESC
DUSTRESN
DUSTRESU
DUDTC
1
DMD-LGE
DU
301
ABC001
1
12345678
ANTPLANE
Anatomical Plane
SAGITTAL
SAGITTAL
2020-02-21
2
DMD-LGE
DU
301
ABC001
2
12345678
INTDISTM
Interslice Distance
1
mm
1
1
mm
2020-02-21
3
DMD-LGE
DU
301
ABC001
3
12345678
STHICK
Slice Thickness
1
mm
1
1
mm
2020-02-21
4
DMD-LGE
DU
301
ABC001
4
12345678
PIXSPCX
X-axis Pixel Spacing
2
mm
2
2
mm
2020-02-21
5
DMD-LGE
DU
301
ABC001
5
12345678
PIXSPCY
Y-axis Pixel Spacing
2
mm
2
2
mm
2020-02-21
6
DMD-LGE
DU
301
ABC001
6
12345678
AQMTRXSZ
Image Acquisition Matrix Size
256X256
VOXEL
256X256
256X256
VOXEL
2020-02-21
7
DMD-LGE
DU
301
ABC001
7
12345678
FLDVIEW
Field of View
280X280
mm
280X280
280X280
mm
2020-02-21
8
DMD-LGE
DU
301
ABC001
8
12345678
NUMSLICE
Number of Slices
125
125
125
2020-02-21
9
DMD-LGE
DU
301
ABC001
9
12345678
ATTCRCT
Attenuation Correction Type
FBP
FBP
2020-02-21
10
DMD-LGE
DU
301
ABC001
10
12345678
DECCORR
Decay Correction Indicator
N
N
2020-02-21
11
DMD-LGE
DU
301
ABC001
11
12345678
RANDCORR
Randoms Correction Indicator
N
N
2020-02-21
12
DMD-LGE
DU
301
ABC001
12
12345678
RECONDAT
Reconstruction of Raw Data Type
ITERATIVE
ITERATIVE
2020-02-21
$warningHtml
The RELREC dataset is used to describe the relationship between 2 or more records in different domains. For more information on relating records see SDTMIG v3.4, Section 8.2.