In this study, subjects were randomized to an double blind study were subject were randomized to either nicotine replacement patches or ENDs. In order to maintain the blind, subjects used both the nicotine replacement patches and the ENDS device. Subjects were requested not to smoke, but the number of regular cigarettes used were collected. Subject were seen every Day for 14 days, The nicotine patch was applied at the site every day at rotating sites,.and the ENDS cartridge was replaced. The cartridge was weight when dispended and upon return.
EC was used to represent the collected exposure data.
ECDOSU | ECDOSFRM | ECDOSFRQ | ECROUTE | ECLOC | ECLAT | ECDIR | EPOCH | ECSTDTC |
---|---|---|---|---|---|---|---|---|
PATCH | PATCH | QD | TRANSDERMAL | ARM | RIGHT | UPPER | TREATMENT | 2011-01-14 |
PATCH | PATCH | QD | TRANSDERMAL | ARM | LEFT | UPPER | TREATMENT | 2011-01-15 |
PATCH | PATCH | QD | TRANSDERMAL | ARM | LEFT | UPPER | TREATMENT | 2011-01-24 |
PATCH | PATCH | QD | TRANSDERMAL | ARM | RIGHT | INNER | TREATMENT | 2011-01-25 |
Row | STUDYID | DOMAIN | USUBJID | ECSEQ | ECTRT | ECDOSE | ECDOSU | ECROUTE | ECVAMT | ECVAMT | ECSTDTC | ECENDTC |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | TENDS01 | EC | 10001 | 1 | e-nicotine liquid | 1 | CONTAINER | INHALED | 8 | mL | 2020-06-27 | 2020-07-01 |
2 | TENDS01 | EC | 10001 | 2 | e-nicotine liquid | 1 | CONTAINER | INHALED | 8 | mL | 2020-07-01 | 2020-07-05 |
3 | TENDS01 | EC | 10001 | 3 | e-nicotine liquid | 1 | CONTAINER | INHALED | 8 | mL | 2020-07-05 | 2020-07-10 |
4 | TENDS01 | EC | 10002 | 1 | e-nicotine liquid | 1 | CONTAINER | INHALED | 8 | mL | 2020-09-01 | 2020-09-07 |
5 | TENDS01 | EC | 10002 | 2 | e-nicotine liquid | 1 | CONTAINER | INHALED | 8 | mL | 2020-09-07 | 2020-09-14 |
6 | TENDS01 | EC | 10002 | 3 | e-nicotine liquid | 1 | CONTAINER | INHALED | 8 | mL | 2020-09-14 | 2020-09-21 |
7 | TENDS01 | EC | 10002 | 4 | e-nicotine liquid | 1 | CONTAINER | INHALED | 8 | mL | 2020-09-21 | 2020-09-28 |
8 | TENDS01 | EC | 10002 | 5 | e-nicotine liquid | 1 | CONTAINER | INHALED | 8 | mL | 2020-09-28 | 2020-09-31 |
9 | TENDS01 | EC | 10002 | 6 | e-nicotine liquid | 1 | CONTAINER | INHALED | 8 | mL | 2020-10-31 | 2020-10-08 |
10 | TENDS01 | EC | 10002 | 7 | e-nicotine liquid | 1 | CONTAINER | INHALED | 8 | mL | 2020-10-08 | 2020-10-15 |
11 | TENDS01 | EC | 10002 | 8 | e-nicotine liquid | 1 | CONTAINER | INHALED | 8 | mL | 2020-10-15 | 2020-10-22 |