The subject had a chest CT scan and an abdominal CT scan.

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pr.xpt

Row	STUDYID	DOMAIN	USUBJID	PRSEQ	PRTRT	PRLOC	VISIT
1	ABC	PR	ABC-123	1	CT SCAN	CHEST	BASELINE
2	ABC	PR	ABC-123	2	CT SCAN	ABDOMEN	BASELINE

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An evaluator examines the images of the thoracic and abdominal regions produced by the CT scan and decides whether TAA and AAA are present as well as their locations. Note for viewing simplicity, some variables are omitted from the table below.

Rows 1-3:	Examination of the thoracic region indicates the presence of an aneurysm in the Thoracic Aorta spanning from the aortic arch to the descending aorta. It also shows that the descending aorta had dissected (the artery is tore and a false lumen had formed), most likely due to the enormous pressure caused by the large aneurysm in this area.
Rows 4-6:	Examination of the abdominal region indicates the presence of an aneurysm in the infrarenal aorta, proximal to the iliac bifurcation. it also shows that infrarenal aorta had dissected.

tu.xpt

Row	STUDYID	DOMAIN	USUBJID	TUSEQ	TUGRPID	TULNKID	TUTESTCD	TUTEST	TULOC	TUORRES	TUSTRESC	TURESLOC	TURLODTL	TUMETHOD	VISITNUM	VISIT	TUDTC
1	ABC	TU	ABC-123	1	1		LESIONIND	Lesion Indicator	Thoracic region	Y	Y			CT SCAN	1	BASELINE	2020-04-27
2	ABC	TU	ABC-123	2	1	Aneurysm 1	ABNEXAM	Examination for Abnormality	Thoracic region	Aneurysm	Aneurysm	Thoracic Aorta	Aortic Arch to Descending aorta	CT SCAN	1	BASELINE	2020-04-27
3	ABC	TU	ABC-123	3	1	Dissection 1	ABNEXAM	Examination for Abnormality	Thoracic region	Arterial Dissection	Arterial Dissection	Descending aorta		CT SCAN	1	BASELINE	2020-04-27
4	ABC	TU	ABC-123	4	2		LESIONIND	Lesion Indicator	Abdominal region	Y	Y			CT SCAN	1	BASELINE	2020-04-27
5	ABC	TU	ABC-123	5	2	Aneurysm 2	ABNEXAM	Examination for Abnormality	Abdominal region	Aneurysm	Aneurysm	Infrarenal aorta	proximal to the iliac bifurcation	CT SCAN	1	BASELINE	2020-04-27
6	ABC	TU	ABC-123	6	2	Dissection 2	ABNEXAM	Examination for Abnormality	Abdominal region	Arterial Dissection	Arterial Dissection	Infrarenal aorta	proximal to the iliac bifurcation	CT SCAN	1	BASELINE	2020-04-27

Dataset Debug Message

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Dataset Wrapper Debug Message

Please add a row column to your dataset.

Diameters of the identified aneurysms are measured and are mapped to TR. LNKID is used to link TU and TR.

Rows 1-2:	Length and maximal luminal diameter of the thoracic aortic aneurysm where LNKID = Aneurysm 1.
Rows 3-4:	Length and maximal luminal diameter of the thoracic aortic aneurysm where LNKID = Aneurysm 2.

tr.xpt

Row	STUDYID	DOMAIN	USUBJID	TRSEQ	TRLNKID	TRTEST	TRORRES	TRORRESU	TRMETHOD	VISITNUM	VISIT	CVDTC
1	ABC	TR	ABC-123	1	Aneurysm 1	Length	4	cm	CT SCAN	1	BASELINE	2020-04-27
2	ABC	TR	ABC-123	2	Aneurysm 1	Maximal Luminal Diameter	3	cm	CT SCAN	1	BASELINE	2020-04-27
3	ABC	TR	ABC-123	3	Aneurysm 2	Length	5	cm	CT SCAN	1	BASELINE	2020-04-27
4	ABC	TR	ABC-123	4	Aneurysm 2	Maximal Luminal Diameter	4	cm	CT SCAN	1	BASELINE	2020-04-27

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Dataset Wrapper Debug Message

Please add a row column to your dataset.

Modeling TU/TR data in CV.

cv.xpt

ROW	STUDYID	DOMAIN	USUBJID	CVSEQ	CVLNKID	CVGRPID	CVTESTCD	CVTEST	CVCAT	CVLOC	CVORRES	CVORRESU	CVSTRESC	CVRESLOC	CVRLODTL	CVMETHOD	VISITNUM	VISIT	CVDTC
1	ABC	CV	ABC-123	1		Region 1	LESIONIND	Lesion Indicator	LESION IDENTIFICATION	Thoracic region	Y		Y			CT SCAN	1	BASELINE	2020-04-27
2	ABC	CV	ABC-123	2		Region 1 Aneurysm 1	ABNEXAM	Examination for Abnormality	LESION IDENTIFICATION	Thoracic region	Aneurysm		Aneurysm	Thoracic Aorta	Aortic Arch to Descending aorta	CT SCAN	1	BASELINE	2020-04-27
3	ABC	CV	ABC-123	3	Region 1-Dissection 1		ABNEXAM	Examination for Abnormality	LESION IDENTIFICATION	Thoracic region	Arterial Dissection		Arterial Dissection	Descending aorta		CT SCAN	1	BASELINE	2020-04-27
4	ABC	CV	ABC-123	4		Region 2	LESIONIND	Lesion Indicator	LESION IDENTIFICATION	Abdominal region	Y		Y			CT SCAN	1	BASELINE	2020-04-27
5	ABC	CV	ABC-123	5		Region 2-Aneurysm 1	ABNEXAM	Examination for Abnormality	LESION IDENTIFICATION	Abdominal region	Aneurysm		Aneurysm	Infrarenal aorta	proximal to the iliac bifurcation	CT SCAN	1	BASELINE	2020-04-27
6	ABC	CV	ABC-123	6	Region 2-Dissection 2		ABNEXAM	Examination for Abnormality	LESION IDENTIFICATION	Abdominal region	Arterial Dissection		Arterial Dissection	Infrarenal aorta	proximal to the iliac bifurcation	CT SCAN	1	BASELINE	2020-04-27
7	ABC	CV	ABC-123	7		Region 1 Aneurysm 1	LENGTH	Length	LESION PROPERTIES		4	cm				CT SCAN	1	BASELINE	2020-04-27
8	ABC	CV	ABC-123	8		Region 1 Aneurysm 1	MAXLDIA	Maximal Luminal Diameter	LESION PROPERTIES		3	cm				CT SCAN	1	BASELINE	2020-04-27
9	ABC	CV	ABC-123	9		Region 2-Aneurysm 1	LENGTH	Length	LESION PROPERTIES		5	cm				CT SCAN	1	BASELINE	2020-04-27
10	ABC	CV	ABC-123	10		Region 2-Aneurysm 1	MAXLDIA	Maximal Luminal Diameter	LESION PROPERTIES		4	cm				CT SCAN	1	BASELINE	2020-04-27

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The dissected descending aorta (LNKID =Dissection 1) is classified based on the Stanford Aortic Dissection System as type B.

Note: This test was originally created as a CVTEST, based on SDTMIG 3.4, this is now considered as a grading scale and therefore should now be represented as CC/RS.

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rs.xpt

Row	STUDYID	DOMAIN	USUBJID	RSSEQ	RSLNKID	RSTESTCD	RSTEST	RSCAT	RSORRES	RSSTRESC	VISITNUM	VISIT	CVDTC
1	ABC	RS(CC)	ABC-123	1	Region 1-Dissection 1	STAN0101	STAN01-Stanford Aortic Dissection Classification Type	STANFORD AOD CLASSIFICATION	STANFORD B	STANFORD B	1	BASELINE	2020-04-27

Dataset Debug Messages

There seem to be multiple domains (RS(CC)) present in the dataset.
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What goes into TULOC?

After all this, i struggle with what values should go into TULOC. When a CT scans the chest, it produces cross-sectional images of the chest/thorax and everything in it. You can view the images in three angles: a) axial view (you are looking at the picture of the thorax from the direction of head to toe), b) the coronal view (you are looking at the images of the thorax as if you are standing in front of the person), c) sagittal view (you are looking at the picture of the thorax from the side). Hence TULOCs are populated with Thoracic Region and Abdominal Region for now. Especially in the axial view, as you move from cross-sectional images of the thorax to images of the abdomen, you are looking at sectioned images of the thoracic region to abdominal region, there is no mistake about which region you are looking at because the anatomy of both regions are so different and clearly sperpated. I think it is not wrong to populate TULOC with chest and abdomen as well, they are just not the most precise anatomical terms.

Questions and Thoughts

Imaging modality for the CV-imaging project:

Coronary angiography:

Done on the chest area, the probe rotates around the chest of the subject, but there is no such a thing as "chest Coronary angiography", it is simply called Coronary angiography.
Creates images of the entire coronary artery system.
We don't record PRLOC = chest for this procedure

Thransthoracic Echocardiogram (TTE):

Done on the chest and upper abdominal wall. The transducer is placed on various parts of the chest and upper belly to create ultrasonic views different views of the heart. Again, there is no such a thing as chest TTE.
Creates images of the heart.
We don't record PRLOC = Chest and upper abdomen for this procedure

Transesophageal Echocardiogram (TEE):

Transducer is inserted into the Esophagus.
Creates images of the heart.
We don't record PRLOC = Esophagus

Cine Angiography:

Done on the chest, again the probe is placed on top of the chest.
Creates images of the entire coronary artery system.

In addition, i just recently took a family member to have a Thyroid Ultrasound:

The ultrasound probe moved around her neck
Creates images of the thyroid gland. In this case would you argue that PRLOC is thyroid or neck?

Referring to Richard M's email:

LOC in the interventions class is "Anatomical focus of an intervention - at which part of the body an intervention is being made". This also my understanding as well.

The "injection" intervention has an anatomical focus - the anatomical site of injection.
Percutaneous Coronary Intervention (also known as angioplasty with stent), has an anatomical location where the procedure occurs, intervenes and alters the abnormal structure of the location - i.e. in the RIGHT POSTERIOR DESCENDING ARTERY (PRLOC), the angioplasty breaks up the blockage and inserts a stent.
Brachytherapy places radioactive material inside a location of the body to kill cancer cells, e.g. prostate. The procedure occurs, intervenes and alters the abnormal structure of the location.

It is easy to pinpoint a location for invasive/treatment type interventions and this aligns with my understanding of how PRLOC should be used.

However, for "diagnostic imaging" procedures, where the imaging probe is placed (i.e. neck, chest, abdomen, head, etc.), Is this really the location where a intervention is "made"?

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What goes into TULOC?

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CV-imaging Example 2, Aneurysms and Arterial Dissection

What goes into TULOC?