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- Is row 4 to delineate between 2D/3D/4D strain analysis LV chamber views?
- Question for Jon Neville - does ANMETH fit for the place to put the chamber view ofr the MR visualization?
- Would it be better to show one segment across the different dimensional chamber views at 2 or 3 timepoints? 1, 2, 5 yr point - could do one with change and one without change.
- Is there a best terminology to use for the dimensions? check CT, 2D, 3D, 4D OR two-dimensional, three-dimensional, four-dimensional (2D is peak radial strain; 3D is peak circumferential strain, 4D is peak longitudinal strain..... is "peak" assumed or does that need to be there?)
- What test is used to measure fibrosis - is it LGE or strain?
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-20 is a good result, -10 is a poor result. Could show change over time with first assessment normal, one example could have poor 1 year follow-up and the other can have stable cardiomyopathy disease. Or could just do this.This example shows the representation of circumferential and longitudinal strain findings in the CV domain. The sponsor used the "CMRBRANDTYP Feature Tracking" analysis method (CVANMETH).
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| Rowcaps |
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| Rows 1-3: | Show circumferential strain |
with a 3 dimensional chamber view (CVANMETH) of the left ventricular basal anterior segment, left ventricular basal anteroseptal segment, and left ventricular basal inferoseptal segment (CVLOC)| for the left ventricle base, mid, and apex regions. | | Row 4: |
? - delete? If yes, shall we delete the 4D in the location of rows 5 & 6? | | Shows circumferential strain for the LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENT. | | Row 5: | Shows global circumferential strain. | | Rows 6-8: | Show longitudinal strain for 4 chamber, 3 chamber, and 2 chamber views. | | Row 9: | Shows longitudinal strain for the LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENT. | | Row 10: | Shows global longitudinal strain |
Rows 5-6: | Show circumferential strain with a 4 dimensional chamber view of the left ventricular basal inferoseptal segment and the left ventricular mid inferoseptal segment |
| Dataset2 |
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Row | STUDYID | DOMAIN | USUBJID | CVSEQ | CVTESTCD | CVTEST | CVORRES | CVORRESU | CVSTRESC | CVSTRESN | CVSTRESU | CVLOC | CVMETHOD | CVANMETH | CVLOBFXL | VISITNUM | VISIT | CVDTC |
| CVIMVIEW |
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| 1 | DMD-CLS | CV | DMD-CLS-01-401 | 1 | CFSTRAIN |
CIRCUMFERENTIAL STRAIN| Circumferential Strain | | % | | -9 | % |
LEFT VENTRICULAR BASAL ANTERIOR SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING | HEART, LEFT VENTRICLE, BASE | MRI | CMRBRANDTYP Feature Tracking |
3D -3 chamber viewSCREENING| VISIT 1 | 2023-09-01 |
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| | 2 | DMD-CLS | CV | DMD-CLS-01-401 | 2 | CFSTRAIN |
CIRCUMFERENTIAL STRAIN| Circumferential Strain | | % | | -12 | % |
LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING | | HEART, LEFT VENTRICLE, MID | MRI | CMRBRANDTYP Feature tracking |
3D - 30chamber viewSCREENING| VISIT 1 | 2023-09-01 |
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| | 3 | DMD-CLS | CV | DMD-CLS-01-401 | 3 | CFSTRAIN | Circumferential Strain | | % | | -10 | % | HEART, LEFT VENTRICLE, APEX | MRI | CMRBRANDTYP Feature tracking |
| 1 | VISIT 1 | 2023-09-01 |
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| | 4 | DMD-CLS | CV | DMD-CLS-01-401 | 4 | CFSTRAIN |
CIRCUMFERENTIAL STRAIN| Circumferential Strain | | % | | -12 | % | LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENT |
CARDIAC MAGNETIC RESONANCE IMAGING | 3D - 3 chamber view | 1 | | MRI | CMRBRANDTYP Feature tracking |
| 1 | VISIT 1 | 2023-09-01 |
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| | 5 | DMD-CLS | CV | DMD-CLS-01-401 | 5 | GCS | Global Circumferential Strain | | % | | -10 | % | HEART, LEFT VENTRICLE | MRI | CMRBRANDTYP Feature tracking |
| 1 | VISIT 1 | 2023-09-01 |
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| | 6 | DMD-CLS | CV | DMD-CLS-01-401 | 6 | LOSTRAIN | Longitudinal Strain | | % | | -18 | % | | MRI | CMRBRANDTYP Feature Tracking |
| 1 | VISIT 1 |
SCREENING | 2023-09-01 |
| 4-CHAMBER | | 7 | DMD-CLS | CV | DMD-CLS-01-401 |
4 | LNGSTRAIN | LONGITUDINAL STRAIN | | CARDIAC MAGNETIC RESONANCE IMAGING | 4D - 4 chamber view | 1 | | 7 | LOSTRAIN | Longitudinal Strain | | % | | -20 | % | | MRI | CMRBRANDTYP Feature tracking |
| 1 | VISIT 1 | 2023-09-01 |
| 3-CHAMBER | | 8 | DMD-CLS | CV | DMD-CLS-01-401 | 8 | LOSTRAIN | Longitudinal Strain | | % | | -15 | % | | MRI | CMRBRANDTYP Feature tracking |
| 1 | VISIT 1 |
SCREENING55LNGSTRAINLONGITUDINAL STRAIN| Longitudinal Strain | | % | | -14 | % | LEFT VENTRICULAR |
4 CHAMBER | BASAL INFEROSEPTAL SEGMENT |
CARDIAC MAGNETIC RESONANCE IMAGING | | MRI | CMRBRANDTYP Feature tracking |
4D - 4 chamber viewSCREENING6
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| | 10 | DMD-CLS | CV | DMD-CLS-01-401 |
6LNGSTRAIN | | LGS | Global Longitudinal Strain |
LONGITUDINAL STRAIN131313LEFT VENTRICULAR MID INFEROSEPTAL SEGMENT | | HEART, LEFT VENTRICLE | MRI | CMRBRANDTYP Feature tracking |
CARDIAC MAGNETIC RESONANCE IMAGINGSCREENING |
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| Variable | Label | Type | Role | Origin |
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| Imaging View | text | Non-standard Record Qualifier | CRF |
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