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This is an example of a study designed to evaluate plasma nicotine pharmacokinetic (PK) parameters following the use of nicotine  nicotine. Two different nicotine products were used in the study. Each product was evaluated in a 180-minute test session ..1–3 with 1-3 days in between each product use. Plasma samples were taken at 45, 30, and 15 minutes prior to the start of product use and 2, 4, 7, 10, 15, 20, 30, 40, 50, 60, and 120 ,  minutes after the start of product use. (More  More time points were are often used, ; these timepoints presented were used only for illustration to save space.).  (C_max), time to reach C_max (t_max), and the baseline-corrected area under the plasma concentration–time curves (i) from start of product use (t₀) to the last quantifiable nicotine concentration time point (AUC_0-last) and (ii) from t₀ to 10 minutes after t₀ (AUC_0-10’). The pharmacokinetic parameters were derived from plasma nicotine concentrations-versus-time data by means of non-compartmental analysis. and corrected for baseline where the baseline (C₀) was defined as the average concentration of the three time points prior to t₀ (45, 30, and 15 minutes prior to t₀).  The analysis methods for the baseline corrected values were provided in the study protocol. 

The PCLLOQ for the analytes measured were reported, the ; PCULOQs were not reported.  

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Rowcaps Rows 1-3: Show the Day 1  day 1 pre-dose concentrations of nicotine in plasma at 45, 30 and 15 min before start of delivery of the nicotine.  PCDTC is populated to indicate when these specimens were collected. Rows 4-8: Show the Day day 1 post drug concentrations of nicotine in plasma after the start of delivery of the nicotine.  Rows 89-16  16:   Show the Day day 4 pre- and post-dose concentrations of nicotine in plasma.  Rows 917-1018: Show the Day day 1 pre-dose plasma concentrations of cotinine and N'-Nitrosonornicotine in plasma. Image Removed Dataset2 Row STUDYID DOMAIN USUBJID PCSEQ PCGRPID PCREFID PCTESTCD PCTEST PCCAT PCSPEC PCORRES PCORRESU PCSTRESC PCSTRESN PCSTRESUPCSTAT PCLLOQPCULOQ VISITNUM VISIT VISITDY PCDTC PCDY PCTPT PCTPTNUM PCTPTREF PCRFTDTC PCELTM 1 ABC-123A123 PC 123-0001A2008 1 Day 1 A10 NICOTNE Nicotine Nicotine ANALYTE PLASMA <0.1 ng/mL <0.1 ng/mL 0.10 1 DAY 1 1 2001-02-01T07:15 1 45MIN  45 MIN PREDOSE 1 Day 1 Dose 20012021-02-01T08:00 -PT45M 2 ABC-123A123 PC 123-0001A2008 2 Day 1 A11 NICOTINE Nicotine  Nicotine ANALYTE PLASMA <1.0 ng/mL <1.0 0.10 1 Day1 1 2001-02-01T07:30 1 30 MIN PREDOSE 2 Day 1 Dose 20012021-02-01T08:00 -PT30M 3 ABC-123A123 PC 123-0001A2008 3 Day 1 A12 NICOTINE Nicotine ANALYTE PLASMA <1.0 ng/mL <0.1 ng/mL 0.1020 1 DAY 1 1 2001-02-01T07:45 1 15 MIM MIN PREDOSE 3 Day 1 Dose 20012021-02-01T08:00 -PT15M 4 ABC-123A123 PC 123-0001A2008 4Day1  Day 1 A13 NICOTINE Nicotine ANALYTE PLASMA 1.5 ng/mL 1.5 1.5 ng/mL 0.10500 1 DAY 1 1 2001-02-01T08:02 12M 2 MIN 4 Day 1 Dose 20012021-02-01T08:00 PT2M 5 ABC-123A123 PC 123-0001A2008 5 Day 1 A14 NICOTINE Nicotine Nicotine ANALYTE PLASMA 3.0 ng/mL 3.0 3.0 ng/mL 0.10500 1 DAY 1 1 2001-02-01T08:04 14M 4 MIN 5 Day 1 Dose 20012021-02-01T08:00 PT4M 6 ABC-123A123 PC 123-0001A2008 6 Day 1 A15 NICOTINE Nicotine ANALYTE PLASMA 8.0 ng/mL 8.0 8.0 ng/mL 0.10 1 DAY 1 1 2001-02-01T08:08 18M 8 MIN 6 Day 1 Dose 20012021-02-01T08:00 PT8M 7 ABC-123A123 PC 123-0001A2008 7 Day 1 A16 NICOTINE Nicotine ANALYTE PLASMA 5.0. ng/mL 5.0 5.0 ng/mL 0.10 1 DAY 1 1 2001-02-01T09:00 160M 60 MIN 7 Day 1 Dose 20012021-02-01T08:00 PT60 8 ABC-123A123 PC 123-0001A2008 8 Day 1 A16 NICOTINE Nicotine ANALYTE PLASMA 3.0 ng/mL 3.0 3.0 ng/mL 0.1020 1 DAY 1 1 2001-02-01T010:00 1120M 120 MIN 8 Day 1 Dose 20012021-02-01T08:00 PT120 9 ABC-123A123 PC 123-0001A2008 9 Day 4 A17 NICOTINE Nicotine ANALYTE PLASMA 5.44 ng/mL 5.44 5.44 ng/mL 0.1020 2 DAY 4 4 2001-02-04T107:15 4 45MIN  45 MIN PREDOSE 1 Day 4 Dose 20012021-02-04T08:00 -PT45M 10 ABC-123A123 PC 123-0001A2008 10 Day 4 A18 NICOTINE Nicotine ANALYTE PLASMA 1.09 ng/mL 1.09 1.09 ng/mL 0.1020 2 DAY 4 4 2001-02-04T07:30 4 30MIN 30 MIN PREDOSE 2 Day 4 Dose 20012021-02-04T08:00 -PT30M 11 ABC-123A123 PC 123-0001A2008 11 Day 4 A19 NICOTINE Nicotine ANALYTE PLASMA <0.1 ng/mL <0.1 ng/mL 0.10 20 2 DAY 4 4 2001-02-04T07:15 4 15 MIN REDOSE 3 Day 4 Dose 20012021-02-04T08:00 -PT15M 13 ABC-123A123 PC 123-0001A2008 12 Day 4 A20 NICOTINE Nicotine ANALYTE PLASMA 3.41 ng/mL 3.41 3.41 ng/mL 0.1020 2 DAY 4 4 2001-02-04T08.02 42M 2 MIN 4 Day 4 Dose 20012021-02-04T08:00 PT2M 13 ABC-123A123 PC 123-0001A2008 13 Day 4 A21 NICOTINE Nicotine ANALYTE PLASMA <0.1 ng/mL <0.1 ng/mL 0.1020 2 DAY 4 4 2001-02-04T08:04 44M 4 MIN 5 Day 4 Dose 20012021-02-04T08:00 PT4M 14 ABC-123A123 PC 123-0001A2008 14 Day 4 A22 NICOTINE Nicotine ANALYTE PLASMA 8.74 ng/mL 8.74 8.74 ng/mL 0.1020 2 DAY 4 4 2001-02-04T008.:08 48M 8 MIN 6 Day 4 Dose 20012021-02-04T08:00 PT8M 15 ABC-123A123 PC 123-0001A2008 15 Day 4 A23 NICOTINE Nicotine ANALYTE PLASMA 4.2 ng/mL 4.2 4.2 ng/mL 0.1020 2 DAY 4 4 2001-02-04T09:00 460M 60 MIN 7 Day 4 Dose 20012021-04-11T08:00 PT160M 16 ABC-123A123 PC 123-0001A2008 16 Day 4 A24 NICOTINE Nicotine ANALYTE PLASMA 245 ng/mL 245 245 ng/mL 0.10500 2 DAY 4 4 2001-02-04T010:00 4120M 120 MIN 8 Day 4 Dose 20012021-04-11T08:00 PT120M 17 ABC-123A123 PC 123-0001A2008 17 Day 1 A10 COTININE Cotinine Cotinine ANALYTE PLASMA 1 ng/mL 1 <0.1 ng/mL .075 1 DAY 1 1 2001-02-01T07:15 1 45MIN  45 MIN PREDOSE 1 Day 1 Dose 20012021-02-01T08:00 -PT45M 18 ABC-123A123 PC 123-0001A2008 18 Day 1 A10 NNN N'-Nitrosonornicotine ANALYTE PLASMA <0.1 pg/mL <.3 pg/mL 0.3 1 DAY 1 1 2001-02-01T07:15 1 45MIN  45 MIN PREDOSE 1 Day 1 Dose 20012021-02-01T08:00 -PT45M