The following examples illustrate how the ingredients of a tobacco product would be represented and quantified using three datasets:
...
All three datasets make use of the SPTOBID variable to identify the tobacco product under study, and the IGDCMPID (Substance Reference Identifier) variable to represent the ingredient name. IGDCMPID must be assigned by study sponsors to be unique with regard to the attributes that describe it. If, for instance, the same ingredient varies on one or more attribute (e.g., two different manufacturers supplied the same ingredient, each with different purities, that is used in two different components of the product), IGDCMPID must be unique for each use to reflect this difference, even if they share the same common name, and/or the same IUPAC name and CAS number. See IT example which illustrates this below.
The IT IT
...
example below shows tobacco filler and the 4 types of tobacco of which it is comprised composed, each listed as tobacco ingredients (IGDCMPIDin the variable IGDCMPID (ingredient or component identifier) for the Tobacco Product tobacco product CIG01A (SPTOBID). The variable ITSPECIF shows the specification (/variety ) of the first three 3 tobaccos. ITIGDPLX (Ingredient Complexity) is used to indicate that Reconstituted Tobacco is a complex ingredient. (it has two more components) the tobacco filler and the reconstituted tobacco are complex ingredients (i.e., have 2 or more subcomponents). The details of which single tobacco ingredients compose these complex ingredients is made explicit in the IQ dataset example. ITCURMTH indicates the cure method. ITSPFL ITCIGIND (applicant-customized ingredient indicator) is used to indicate whether complex ingredients were made to the applicant's specification. TPMF indicates the Tobacco Product Master File. File name/number, which should be provided in the data if the component manufacturer has made it available.
Note that there are two 2 varieties of burley tobacco in this tobacco product, thus ; each is given a unique IGDCMPID value (Burley Tobacco and Burley Tobacco 2).Note that following the team discussion on 12/13/22, we have added tobacco filler to the IT
...
...
| dataset-wrap |
|---|
|
| Dataset2 |
|---|
| | STUDYID | SPTOBID | IGDCMPID | TPMF | ITSPECIF | ITIGDPLX | ITCURMTH | ITSPFLITCIGIND |
|---|
| 1 | IT | TOB07 | CIG01A | Tobacco Filler |
|
| COMPLEX INGREDIENT |
|
|
|---|
| 2 | IT | TOB07 | CIG01A | Burley Tobacco | MF5555555 | NC 7LC | SINGLE INGREDIENT | Air |
|
|---|
| 3 | IT | TOB07 | CIG01A | Bright Tobacco |
| CC 1063 | SINGLE INGREDIENT | Flue |
|
|---|
| 4 | IT | TOB07 | CIG01A | Oriental Tobacco |
| USDA Nicotiana Collection PI 552747 | SINGLE INGREDIENT | Sun |
|
|---|
| 5 | IT | TOB07 | CIG01A | Reconstituted Tobacco |
|
| COMPLEX INGREDIENT |
| N |
|---|
| 6 | IT | TOB07 | CIG01A | Burley Tobacco 2 |
| KT215LC | SINGLE INGREDIENT | Air |
|
|---|
|
|
The IN dataset example below shows the list of non-tobacco ingredients used in the tobacco product identified as CIG01A. Each unique ingredient is listed in IGDCMPID. Where applicable, IUPAC name and CAS number are listed (IUPACNAM and CASNO variables, respectively). INIGDPLX is used to indicate whether an ingredient is a single ingredient or a complex ingredient. INSPFL indicates INCIGIND indicates whether complex ingredients were made to the applicant's specification. Grade, purity, manufacturer name and ID , ingredient unique item number, and the Tobacco Product Master File number File number complete the dataset.
| Dataset wrap |
|---|
|
| Dataset2 |
|---|
| Row | DOMAIN | STUDYID | SPTOBID | IGDCMPID | INMANUF | INMANUFNINMANUIN | TPMF | IUPACNAM | CASNO | UNII | INIGDPLX | INSPFLINCIGIND | INGRADE | INPURTY |
|---|
| 1 | IN | TOB07 | CIG01A | Cocoa Extract | Flavor House A | FLVR1234 | MF5555555 |
|
|
| COMPLEX INGREDIENT | N | FOOD |
|
|---|
| 2 | IN | TOB07 | CIG01A | Butyric Acid |
|
|
| butanoic acid | 107-92-6 |
| SINGLE INGREDIENT |
| FoodUSP | ≥99% |
|---|
| 3 | IN | TOB07 | CIG01A | Cellulose Filter A | MFR A | FIL789 |
|
| - |
| COMPLEX INGREDIENT | N | USP |
|
|---|
| 4 | IN | TOB07 | CIG01A | Cellulose Acetate |
|
|
| cellulose acetate | 9004-35-7 |
| SINGLE INGREDIENT |
|
| 99% |
|---|
| 5 | IN | TOB07 | CIG01A | Triacetin |
|
|
| 1,3-diacetyloxypropan-2-yl acetate | 102-76-1 |
| SINGLE INGREDIENT |
| USP |
|
|---|
| 6 | IN | TOB07 | CIG01A | FSC Paper B | MFR B | FSC123 | MF5678910 |
|
|
| COMPLEX INGREDIENT | N |
|
|
|---|
| 7 | IN | TOB07 | CIG01A | Cellulose Pulp |
|
|
| cellulose pulp | 65996-61-4 |
| SINGLE INGREDIENT |
|
| ≥99% |
|---|
| 8 | IN | TOB07 | CIG01A | Calcium Carbonate |
|
|
| calcium carbonate | 471-34-1 |
| SINGLE INGREDIENT |
| USP |
|
|---|
| 9 | IN | TOB07 | CIG01A | Sodium Alginate |
|
|
| sodium;3,4,5,6-tetrahydroxyoxane-2-carboxylate | 9005-38-3 |
| SINGLE INGREDIENT |
| FOOD |
|
|---|
| 10 | IN | TOB07 | CIG01A | Trisodium Citrate |
|
|
| trisodium;2-hydroxypropane-1,2,3-tricarboxylate | 6132-04-3 |
| SINGLE INGREDIENT |
|
| ≥98% |
|---|
| 11 | IN | TOB07 | CIG01A | Cationic Starch |
|
|
| starch, 2-hydroxy-3-(trimethylammonio)propyl ether, chloride | 56780-58-6 |
| SINGLE INGREDIENT |
| FOOD |
|
|---|
| 12 | IN | TOB07 | CIG01A | Seam Adhesive | MFR C | ADV123 | MF2345678 | - |
|
|
| COMPLEX INGREDIENT | N |
|
|
|---|
| 13 | IN | TOB07 | CIG01A | Methylcellulose |
|
|
|
| 9004-67-5 |
| SINGLE INGREDIENT |
| FOOD |
|
|---|
| 14 | IN | TOB07 | CIG01A | 1,3-Butanediol |
|
|
| Butane-1,3-diol | 34844-08-1 |
| SINGLE INGREDIENT |
| USP | ≥99% |
|---|
|
|
Finally, the IQ domain is used to represent the quantity (target, minimum, and maximum) of each ingredient identified in IGDCMPID that the product (SPTOBID) is designed to contain, with the units for these values represented in IQUNIT. The function of each ingredient is described in IQFUNCT. Note: Ingredients that appear in more than one 1 component of the tobacco product are quantified separately for each component. IQPARENT and IQLEVEL are used to identify the component/ingredient of which the ingredient in a record is a constituent component, and and at which level in the overall hierarchy the constituent ingredient appears. The following implementation rules applyidentifies a component or complex ingredient composed of the subcomponents/ingredients shown in IDGCMPID. IQLEVEL is used to identify at what level in the overall hierarchy that subcomponent/ingredient appears.
The following implementation rules apply, as described in more detail in Section 2.8.8.6, SDTM Ingredient Quantities by Component (IQ), Assumptions:
- IQPARENT must correspond to a value of IGDCMPID in the same dataset. If If parent is null, the ingredient is considered a top-level component and is assigned a an IQLEVEL value of "1" in IQLEVEL.
- Records describing subcomponents/ingredients that are constituent ingredients of another ingredient/compose a parent component listed in the dataset will have IQPARENT value equal to the IGDCMPID of that ingredient/parent component. IQLEVEL will be set to n +1, where n = the parent record's value of IQLEVEL.
- Every value of IGDCMPID used in the IQ dataset must have a matching value of IGDCMPID:
- In the IT dataset (when IQCAT=TOBACCO INGREDIENT), or,
- In the IN dataset (when IQCAT=NON-TOBACCO INGREDIENT)
Therefore, IQCAT is required to relate ingredient quantity records in IQ to the associated ingredient attributes described in either IT or IN.
The use of IQLPARENT IQPARENT and IQLEVEL help make explicit the relationship between complex ingredients and their constituentsor components and the subcomponents/ingredients of which they are composed, and can assist when totaling the quantities of an ingredient that appears in multiple components of a tobacco product.
The This concept map below illustrates the representation of the hierarchical relationships between a complex ingredient component and its constituent subcomponents/ingredients in the IQ domain structure.
| Excerpt Include |
|---|
| Concept Map. Relationships of Complex Components, Subcomponents and Ingredients in IQ |
|---|
| Concept Map. Relationships of Complex Components, Subcomponents and Ingredients in IQ |
|---|
|
The IQ dataset example illustrates the these principles discussed above , using a cigarette tobacco product:
| Dataset wrap |
|---|
|
| Rowcaps |
|---|
| Rows 1, 13, 16: | Show three 3 top-level components of a cigarette product: tobacco filler, filter, and cigarette paper, respectively. Their target, minimum, and maximum quantities expressed in units of mg/cigarette are shown in IQTARGIQVALTRG, IQMINIQVALMIN, IQMAX IQVALMAX and IQUNIT. Because there is no parent component other than the finished product itself, IQPARENT is null, and IQLEVEL=1, indicating that these are top-level ingredients/components of the finished product. | | Rows 2-5: | Show the quantities of four 4 types of tobacco used in the product. IQPARENT=Tobacco Filler and IQLEVEL=2, together indicating that these are constituents of subcomponents/ingredients in the tobacco filler, a top level-component of the cigarette product. | | Rows 6-8: | Show the three constituent 3 tobacco ingredients that comprise compose reconstituted tobacco in row 5 (IQPARENT=Reconstituted Tobacco). The quantities of these tobaccos pertain to the quantity at which they appear in the reconstituted tobacco ONLY. IQLEVEL=3 to show that these ingredients are at the third level of the hierarchy (subcomponents/ingredients in Reconstituted Tobacco, which has IQLEVEL=2). Therefore, the total quantity of the individual tobaccos used in this tobacco product is the sum of these three 3 rows plus the sum of the quantities shown in rows 12-34. IQLEVEL=3 to show that these ingredients are at the 3rd level of the hierarchy (constituents of an ingredient with IQLEVEL=2). | | Rows 9-10: | Show the quantities of two 2 non-tobacco ingredients, Methylcellulose methylcellulose and 1,3-Butanediolbutanediol, which are further constituent subcomponents/ingredients of in Reconstituted Tobacco, as indicated by IQPARENT. IQFUNCT shows that Methylcellulose methylcellulose functions as a binder and 1,3-Butanediol butanediol functions as a humectant. IQLEVEL=3 to show that these ingredients are at the 3rd third level of the hierarchy. | | Rows 11-12: | Show the quantities of two constituent 2 subcomponents/ingredients that both function as a flavorant in the tobacco filler (as indicated by IQFUNCT= Flavor and IQPARENT=Tobacco Filler). | | Rows 14-15: | Show the quantities of two constituent 2 subcomponents/ingredients that function as filtration and plasticizer, respectively, in the filter portion of the cigarette (Cellulose Filter cellulose filter A, a top-level component shown in row 13). | | Rows 17-22: | Show the quantities and functions of six constituent ingredients of 6 subcomponents/ingredients in the top-level component FSC Paper paper B (the cigarette paper shown in row 16). |
|
| Dataset2 |
|---|
| Row | DOMAIN | STUDYID | SPTOBID | IGDCMPID | IQCAT | IQPARENT | IQLEVEL | IQFUNCT | IQTARGIQVALTRG | IQMINIQVALMIN | IQMAXIQVALMAX | IQUNIT |
|---|
| 1 | IQ | TOB07 | CIG01A | Tobacco Filler | TOBACCO INGREDIENT |
| 1 |
| 672.5 | 661.3 | 683.7 | mg/cigarette | | 2 | IQ | TOB07 | CIG01A | Burley Tobacco | TOBACCO INGREDIENT | Tobacco Filler | 2 |
| 19 | 17 | 21 | mg/cigarette | | 3 | IQ | TOB07 | CIG01A | Bright Tobacco | TOBACCO INGREDIENT | Tobacco Filler | 2 |
| 300 | 295 | 305 | mg/cigarette | | 4 | IQ | TOB07 | CIG01A | Oriental Tobacco | TOBACCO INGREDIENT | Tobacco Filler | 2 |
| 115 | 113 | 117 | mg/cigarette | | 5 | IQ | TOB07 | CIG01A | Reconstituted Tobacco | TOBACCO INGREDIENT | Tobacco Filler | 2 |
| 231 | 229 | 233 | mg/cigarette | | 6 | IQ | TOB07 | CIG01A | Burley Tobacco 2 | TOBACCO INGREDIENT | Reconstituted Tobacco | 3 |
| 19 | 18 | 20 | mg/cigarette | | 7 | IQ | TOB07 | CIG01A | Bright Tobacco | TOBACCO INGREDIENT | Reconstituted Tobacco | 3 |
| 103 | 101 | 105 | mg/cigarette | | 8 | IQ | TOB07 | CIG01A | Oriental Tobacco | TOBACCO INGREDIENT | Reconstituted Tobacco | 3 |
| 65 | 63 | 67 | mg/cigarette | | 9 | IQ | TOB07 | CIG01A | Methylcellulose | NON-TOBACCO INGREDIENT | Reconstituted Tobacco | 3 | Binder | 20 | 19 | 21 | mg/cigarette | | 10 | IQ | TOB07 | CIG01A | 1,3-Butanediol | NON-TOBACCO INGREDIENT | Reconstituted Tobacco | 3 | Humectant | 24 | 23 | 25 | mg/cigarette | | 11 | IQ | TOB07 | CIG01A | Cocoa Extract | NON-TOBACCO INGREDIENT | Tobacco Filler | 2 | Flavor | 7 | 6.75 | 7.25 | mg/cigarette | | 12 | IQ | TOB07 | CIG01A | Butyric Acid | NON-TOBACCO INGREDIENT | Tobacco Filler | 2 | Flavor | 0.5 | 0.55 | 0.45 | mg/cigarette | | 13 | IQ | TOB07 | CIG01A | Cellulose Filter A | NON-TOBACCO INGREDIENT |
| 1 | Filter | 164 | 163 | 165 | mg/cigarette | | 14 | IQ | TOB07 | CIG01A | Cellulose Acetate | NON-TOBACCO INGREDIENT | Cellulose Filter A | 2 | Filtration | 155 | 154 | 156 | mg/cigarette | | 15 | IQ | TOB07 | CIG01A | Triacetin | NON-TOBACCO INGREDIENT | Cellulose Filter A | 2 | Plasticizer | 9 | 8 | 10 | mg/cigarette | | 16 | IQ | TOB07 | CIG01A | FSC Paper B | NON-TOBACCO INGREDIENT |
| 1 | Cigarette Paper (Wrapper) | 50 | 49 | 51 | mg/cigarette | | 17 | IQ | TOB07 | CIG01A | Cellulose Pulp | NON-TOBACCO INGREDIENT | FSC Paper B | 2 | Fiber | 30 | 29 | 31 | mg/cigarette | | 18 | IQ | TOB07 | CIG01A | Calcium Carbonate | NON-TOBACCO INGREDIENT | FSC Paper B | 2 | Filler | 15 | 14 | 16 | mg/cigarette | | 19 | IQ | TOB07 | CIG01A | Sodium Alginate | NON-TOBACCO INGREDIENT | FSC Paper B | 2 | Reduced ignition propensity | 2 | 1.75 | 2.25 | mg/cigarette | | 20 | IQ | TOB07 | CIG01A | Trisodium Citrate | NON-TOBACCO INGREDIENT | FSC Paper B | 2 | Combustion Modifier | 0.5 | 0.45 | 0.55 | mg/cigarette | | 21 | IQ | TOB07 | CIG01A | Cationic Starch | NON-TOBACCO INGREDIENT | FSC Paper B | 2 | Binder | 0.5 | 0.45 | 0.55 | mg/cigarette | | 22 | IQ | TOB07 | CIG01A | Seam Adhesive | NON-TOBACCO INGREDIENT | FSC Paper B | 2 | Adhesive | 2 | 1.75 | 2.25 | mg/cigarette |
|
|