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This example shows findings from an assessment of ... genomic variations in drug metabolizing genes with the purpose of determining how variations in those genes affect drug absorption, distribution, metabolism, and excretion (ADME). The method used to summarize nucleotide variation is represented in variable GFANMETH where appropriate. Identifying information for the genomic panel is represented in SPDEVID. Additional information about the genomic panel may be represented in the Medical Device Domains (e.g., DI domain) as needed.
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| Rows 1-6, 9-14: | Show variation at a particular allele for the single nucleotide variation identified in GFPVRID. An arbitrary identifier for the allele is represented in GFCOPYID. | | Rows 7, 15: | Show the predicted phenotype based on the unique pattern of nucleotide variation of gene CYP2C19 that is involved in ADME. | | Rows 8, 16: | Show the predicted diplotype based on the unique pattern of nucleotide variation of gene CYP2C19 that is involved in ADME. | Row 1 |
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| | Row | STUDYID | DOMAIN | USUBJID | SPDEVID |
NHOIDGFGRPIDGFSPID | GFLNKID | GFLNKGRPGFCATGFSCAT | GFORRESU | GFORREFGFSTRESN | GFSTRESU | GFSTREFC | GFSTREFN | GFRESCAT | GFINHERT | | GFGENREF | GFCHROM | GFSYM | GFSYMTYP | GFGENLOC |
GFGENSRGFSEQID | GFSTAT | GFREASND | GFXFN | GFRUNID | GFBLFL | GFDRVFL | GFLLOQ | GFREPNUM | | VISITNUM | VISIT | VISITDY | GFDTC | GFDY |
GFTPT | GFTPTNUM | GFELTM | GFTPTREF | GFRFTDTC | | 1 | ABC123 | GF | 100001 | DMET Plus | 1 | A566575 | SNV | Single Nucleotide Variation | ALLELE SEQUENCE | C | C | GRCh37 | 10 | CYP2C19 | GENE WITH PROTEIN PRODUCT | 96521657 | rs12248560 | 1 | ACME Genomics | DNA | MICROARRAY |
| -1 | SCREENING | -1 |
to be added| 2022-04-02 | -2 | | 2 | ABC123 | GF | 100001 | DMET Plus | 2 | A566575 | SNV | Single Nucleotide Variation | ALLELE SEQUENCE | C | C | GRCh37 | 10 | CYP2C19 | GENE WITH PROTEIN PRODUCT | 96521657 | rs12248560 | 2 | ACME Genomics | DNA | MICROARRAY |
| -1 | SCREENING | -1 |
to be added| 2022-04-02 | -2 | | 3 | ABC123 | GF | 100001 | DMET Plus | 3 | A566575 | SNV | Single Nucleotide Variation | ALLELE SEQUENCE | A | A | GRCh37 | 10 | CYP2C19 | GENE WITH PROTEIN PRODUCT | 96541616 | rs4244285 | 1 | ACME Genomics | DNA | MICROARRAY |
| -1 | SCREENING | -1 |
to be added| 2022-04-02 | -2 | | 4 | ABC123 | GF | 100001 | DMET Plus | 4 | A566575 | SNV | Single Nucleotide Variation | ALLELE SEQUENCE | G | G | GRCh37 | 10 | CYP2C19 | GENE WITH PROTEIN PRODUCT | 96541616 | rs4244285 | 2 | ACME Genomics | DNA | MICROARRAY |
| -1 | SCREENING | -1 |
to be added| 2022-04-02 | -2 | | 5 | ABC123 | GF | 100001 | DMET Plus | 5 | A566575 | SNV | Single Nucleotide Variation | ALLELE SEQUENCE | G | G | GRCh37 | 10 | CYP2C19 | GENE WITH PROTEIN PRODUCT | 96540410 | rs4986893 | 1 | ACME Genomics | DNA | MICROARRAY |
| -1 | SCREENING | -1 |
to be added| 2022-04-02 | -2 | | 6 | ABC123 | GF | 100001 | DMET Plus | 6 | A566575 | SNV | Single Nucleotide Variation | ALLELE SEQUENCE | G | G | GRCh37 | 10 | CYP2C19 | GENE WITH PROTEIN PRODUCT | 96540410 | rs4986893 | 2 | ACME Genomics | DNA | MICROARRAY |
| -1 | SCREENING | -1 |
to be added| 2022-04-02 | -2 | | 7 | ABC123 | GF | 100001 | DMET Plus | 7 | A566575 | VARPROF | Variant Profile | PREDICTED PHENOTYPE | IM | IM |
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| CYP2C19 | GENE WITH PROTEIN PRODUCT |
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| ACME Genomics | DNA | MICROARRAY | ADME VARIANT PROFILE | -1 | SCREENING | -1 |
to be added| 2022-04-02 | -2 | | 8 | ABC123 | GF | 100001 | DMET Plus | 8 | A566575 | VARPROF | Variant Profile | PREDICTED DIPLOTYPE | *1/*2 | *1/*2 |
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| CYP2C19 | GENE WITH PROTEIN PRODUCT |
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| ACME Genomics | DNA | MICROARRAY | ADME VARIANT PROFILE | -1 | SCREENING | -1 |
to be added| 2022-04-02 | -2 | | 9 | ABC123 | GF | 100002 | DMET Plus | 1 | A899790 | SNV | Single Nucleotide Variation | ALLELE SEQUENCE | C | C | GRCh37 | 10 | CYP2C19 | GENE WITH PROTEIN PRODUCT | 96521657 | rs12248560 | 1 | ACME Genomics | DNA | MICROARRAY |
| -1 | SCREENING | -1 |
to be added| 2022-04-13 | -1 | | 10 | ABC123 | GF | 100002 | DMET Plus | 2 | A899790 | SNV | Single Nucleotide Variation | ALLELE SEQUENCE | C | C | GRCh37 | 10 | CYP2C19 | GENE WITH PROTEIN PRODUCT | 96521657 | rs12248560 | 2 | ACME Genomics | DNA | MICROARRAY |
| -1 | SCREENING | -1 |
to be added| 2022-04-13 | -1 | | 11 | ABC123 | GF | 100002 | DMET Plus | 3 | A899790 | SNV | Single Nucleotide Variation | ALLELE SEQUENCE | G | G | GRCh37 | 10 | CYP2C19 | GENE WITH PROTEIN PRODUCT | 96541616 | rs4244285 | 1 | ACME Genomics | DNA | MICROARRAY |
| -1 | SCREENING | -1 |
to be added| 2022-04-13 | -1 | | 12 | ABC123 | GF | 100002 | DMET Plus | 4 | A899790 | SNV | Single Nucleotide Variation | ALLELE SEQUENCE | G | G | GRCh37 | 10 | CYP2C19 | GENE WITH PROTEIN PRODUCT | 96541616 | rs4244285 | 2 | ACME Genomics | DNA | MICROARRAY |
| -1 | SCREENING | -1 |
to be added| 2022-04-13 | -1 | | 13 | ABC123 | GF | 100002 | DMET Plus | 5 | A899790 | SNV | Single Nucleotide Variation | ALLELE SEQUENCE | G | G | GRCh37 | 10 | CYP2C19 | GENE WITH PROTEIN PRODUCT | 96540410 | rs4986893 | 1 | ACME Genomics | DNA | MICROARRAY |
| -1 | SCREENING | -1 |
to be added| 2022-04-13 | -1 | | 14 | ABC123 | GF | 100002 | DMET Plus | 6 | A899790 | SNV | Single Nucleotide Variation | ALLELE SEQUENCE | G | G | GRCh37 | 10 | CYP2C19 | GENE WITH PROTEIN PRODUCT | 96540410 | rs4986893 | 2 | ACME Genomics | DNA | MICROARRAY |
| -1 | SCREENING | -1 |
to be added| 2022-04-13 | -1 | | 15 | ABC123 | GF | 100002 | DMET Plus | 7 | A899790 | VARPROF | Variant Profile | PREDICTED PHENOTYPE | EM | EM |
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| CYP2C19 | GENE WITH PROTEIN PRODUCT |
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| ACME Genomics | DNA | MICROARRAY | ADME VARIANT PROFILE | -1 | SCREENING | -1 |
to be added| 2022-04-13 | -1 | | 16 | ABC123 | GF | 100002 | DMET Plus | 8 | A899790 | VARPROF | Variant Profile | PREDICTED DIPLOTYPE | *1/*1 | *1/*1 |
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| CYP2C19 | GENE WITH PROTEIN PRODUCT |
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| ACME Genomics | DNA | MICROARRAY | ADME VARIANT PROFILE | -1 | SCREENING | -1 |
to be added |
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