Late gadolinium enhancement (LGE) increases over time for patients with DMD. Early onset LGE may be used as a prognostic factor since cardiac function has been shown to decline more rapidly for these patients.[5]
LGE assessments can be done on each of the cardiovascular segments as shown in Figure 1.[6]
Excerpt Include Figure 1. Left Ventricular Segments Figure 1. Left Ventricular Segments
The SDTM examples in this section show the findings of a CMR imaging procedure with late gadolinium enhancement. The level of granularity varies with the type of test used; research requirements will determine what level of granularity is needed
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Note from standards discussion - Determined this would be an indicator test and there is an additional term LGE percentage. → is there anything different to do with this? |
Late Gadolinium Enhancement (LGE) is an assessment made with CMR imaging that includes gadolinium contrast administration. The test is done to assess for gadolinium contrast material accumulation in the tissue with increased extracellular space to determine both left and right ventricle fibrosis (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801263/). For LGE, the assessment relates to the timing of the reading showing whether or not the contrast is present or not at the specific time of the reading (would be determined by the protocol but typically is noted approximately 10 minutes after contrast injection). If the LGE is noted as present, more assessments may be done such as presence per segment and the percentage of presence per segment.
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For more information on the domains used in this section see:
The SDTMIG is available at https://www.cdisc.org/standards/foundational/sdtmig. |
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