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This  This is an example of a cross-over crossover study where testing 7 smokeless tobacco products were tested. Subject . All products contain nicotine except for product F, which was a nicotine-/tobacco-free product. Each subject first used the product ad libitum and then ; the next day, the product usage was evaluated in the morning, as specified in the protocol in the morning.    . Subjects were confined to the site. Products were supplied to the subjects as needed by site staff. Each usage was recorded. The applicant did not submit a DA domain, nor an EC domain. The name of the actual product would be used, but a dummy name is used in this example.