Late gadolinium enhancement (LGE) is shown to increase increases over time for patients with DMD. Cardiac magnetic resonance (CMR) imaging is used to assess ventricular function and myocardial fibrosis by LGE. "The time course and distribution of LGE-positivity may be an important clinical biomarker to aid in the management of DMD-associated cardiac disease." (ref: https://jcmr-online.biomedcentral.com/articles/10.1186/1532-429X-15-107)Early onset LGE may be used as a prognostic factor since cardiac function has been shown to decline more rapidly for these patients.[5]
LGE assessments can LGE assessments may be done on each of the cardiovascular segments as shown in Figure 1. (ref: https://www.ahajournals.org/doi/full/10.1161/hc0402.102975)[6]
Excerpt Include Figure 1. Left Ventricular Segments Figure 1. Left Ventricular Segments
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For more information on the domains used in this section see:
The SDTMIG is available at https://www.cdisc.org/standards/foundational/sdtmig. |
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