Cardiorespiratory failure is a common cause of death for patients with Duchenne muscular dystrophy (DMD). Current therapies may delay the progression of heart failure for this population. Measuring left ventricular ejection fraction (LVEF) regularly can show the rate of decline in left ventricle function for a patient.[1]
This section illustrates how the results of several systolic function tests, and accompanying data, are represented using the SDTM.
Add text on Ejection Fraction and DMD.
"Cardiomyopathy with systolic heart failure is the leading cause of death and lower LVEF is an independent predictor of mortality at younger ages in patients with DMD." (ref: https://openres.ersjournals.com/content/9/5/00176-2023)
"Duchenne muscular dystrophy is associated with progressive cardiorespiratory failure, including left ventricular dysfunction." (ref: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8941672/)
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For more information on the domains used in this section, see:
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The SDTMIG is available at https://www.cdisc.org/standards/foundational/sdtmig |
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