Late gadolinium enhancement (LGE) increases over time for patients with DMD. Early onset LGE may be used as a prognostic factor since cardiac function has been shown to decline more rapidly for these patients.[5]
LGE assessments can be done on each of the cardiovascular segments as shown in Figure 1.[6]
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| Figure 1. Left Ventricular Segments |
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| Figure 1. Left Ventricular Segments |
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The SDTM examples in this section show the findings of a CMR imaging procedure with late gadolinium enhancement. The level of granularity varies with the type of test used; research requirements will determine what level of granularity is needed
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- CVORRES: Result of the measurement or finding as originally received or collected.
- CVORRESU: Original units in which the data were collected. Unit for CVORRES.
- CVSTRESC: Result value for all findings from CVORRES in a standard format or in standard units. If results are numeric, they should also be stored in numeric format in CVSTRESN.
- CVSTRESN: Used for continuous or numeric results or findings in standard format; copied in numeric format from CVSTRESC.
- CVSTRESU: Standardized units used for CVSTRESC and CVSTRESN.
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- How many locations to show?
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The following example shows the findings associated with a Cardiac Magnetic Resonance Imaging procedure related to late gadolinium enhancement.
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| ExampleSDTM. Late Gadolinium EnhancementExample |
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| SDTM. Late Gadolinium Enhancement |
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For more information on the domains used in this section see: - Procedures (PR) - SDTMIG v3.4, Section 6.1.5
- Cardiovascular System Findings (CV) - SDTMIG v3.4, Section 6.3.7.2
- Procedure Agents (AG) - SDTMIG v3.4 Section 6.1.1
- Device Identifiers (DI) - SDTMIG-Medical Devices v1.1, Section 3.1
The SDTMIG is available at https://www.cdisc.org/standards/foundational/sdtmig. |