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  1. The Related References domain (RELREF) is a relationship dataset used to describe how information is related to the design of the study and to other sources of information within the study.
  2. To identify a source of information from a genetic toxicology assay within a study, a unique identifier (REFID) must be assigned and assigned and populated in all datasets containing the REFID column. In other words, each GTREFID that exists in the GT dataset must exist in the RELREF dataset.
  3. Each REFID that exists in the SEND RELREF dataset must exist in the GT dataset. 
  4. For each value in PARENT there must exist one record with REFID value = PARENT value. The value of REFID must be unique in the RELREF dataset.
  5. The value for LEVEL must be 1 for a record without a PARENT record.  This record may or may not have a child record.
  6. If a record has a PARENT, LEVEL must be populated with a LEVEL that is sequentially one greater than the PARENT record (e.g., value for LEVEL = value for PARENT LEVEL + 1).