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The objective of population modeling is to study the impact of tobacco products on the population as whole. Input parameters include demographic information, tobacco use transition probability, and mortality and/or morbidity. The input Input parameters are typically derived from population-level sources (e.g., census data or other population-level surveys). However, depending on the objective, other sources of data may be used. When using these other sources, steps should be taken

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to ensure they are representative of the population.

Input parameters are an important component of model development, verification, and validation. In many population models in a tobacco research setting, inputs input parameters are used to incorporate tobacco use behaviors and risks that occur under scenarios of interest. For interest—for example, models to evaluate the health impact associated with introducing a new tobacco or policy that may results result in product switching, dual use, or polytobacco use. Input parameters may be obtained be obtained from a variety of data sources, and depending on the objectives of the model, they could may include population survey surveys representative of the population of interests. For example: interest (e.g., population distribution, birth rates, migration rates, death (or /other morbidities) morbidity rates, tobacco product use behavior prevalence. We provide ). This section provides a characterization of several classes input parameters that are informative in developing the TIG.  

In this section, the inputs to these models and how they are represented in CDISC standards for submission to a regulatory authority are discussed. Model outputs are not currently covered in this section but may be covered in a later release. However, regulatory agencies expect full information to replicate the analysis based in the outputs.

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