| System to Site | System | Query raised automatically by data capture system in response to data quality issue (for example) |
| Data Management to Site | Manual | Query raised by data manager for address by site personnel |
| Site Monitor to Site | Manual | Query raised by site monitor for address by site personnel |
| Coding System to Site | Manual | System | Query raised by coding system requiring clarification from site |
| Safety Reviewer to Site | Manual | Query raised by safety reviewer (often in relation to addressing a serious adverse event) |