Versions Compared

Key

  • This line was added.
  • This line was removed.
  • Formatting was changed.
Excerpt
This example shows different types of histopathological findings for 3 6 different animals.
Dataset wrap
NameMI
Rowcaps
Rows 1-2:For these findings, the specimen consists of tissues from both the testis and the epididymis. Therefore, the list of tissues comprising the specimen becomes the SPEC value for each contributing tissue, noted by a slash, as is found in the controlled terminology list.
Row 2:For this finding, the base pathological process is inflammation, and is recorded in MISTRESC. The term "acute" is recorded in MICHRON using the controlled CHRNCTY codelist term ACUTE.
Row 3:For this finding, the specimen consists of skeletal muscle. The base pathological process is degeneration/regeneration and is represented in MISTRESC. The term "Myofiber" is recorded in MIRESMOD (SUPPMI example).
Row 4:This is an example of a reason why a microscopic evaluation of the mammary gland specimen was not performed. Note that MIORRES is null and MISTAT is "NOT DONE", the reason for the specimen not being evaluated is entered in MIREASND.
Row 5:This shows an example of a record where the specimen contained no pathologic process. A record should be included for every scheduled specimen that was without pathology. The controlled NONNEO term "UNREMARKABLE" is recorded in MISTRESC. Note: There is no MIRESCAT for "UNREMARKABLE" as there is no finding.
Row 6:In this record, the finding was the cause of death; therefore, MIDTHREL is "Y" (Yes).
Row 7:The base pathological process is hyperplasia, recorded into MISTRESC from the NONNEO controlled terminology list. The modifiers "endometrial" and "cystic" are recorded in MIRESMOD (SUPPMI example). Note that the 2 values for MIRESMOD are separated by a semicolon, as required in Section 6.3.8.
Row 8:For this finding, a mass identified as mass 1 (MISPID="MASS 1") is observed on the left ovary (MILAT = "LEFT"). This mass is considered benign (MIRESCAT). Note that MISTRESC contains controlled terminology for the tumor, which may include term(s) similar to characteristics and/or distribution as part of the base pathological process.
Row 9:This is an example of a malignant mass (MISPID = "MASS 2"). The malignancy of the mass is recorded as part of the original result (MIORRES) as well as the controlled term in MIRESCAT. This finding was not the cause of death of the subject (MIDTHREL= "N"). Note that MISTRESC contains only the finding without modifiers. This record is linked to row 11 (via the MIGRPID value of 1) to relate the primary tumor with its metastasis in another tissue. The tumor origin described in MIORRES ("Primary") is associated to the MI records using the supplemental qualifier MIRESMOD (SUPPMI example).
Row 10:This shows an example of a metastasis found in the uterus. The primary site for this tumor is unknown, and the sponsor applicant decided to include row 13 ("SITE, UNCERTAIN PRIMARY") to represent the source tumor. This record is related to rows 12 and 13 via the MIGRPID value of 2.
Row 11:This finding describes a mass (MISPID="MASS 3") that is a metastasis of a primary tumor, which is recorded in the original result (MIORRES). This specific finding did not cause the death of the animal (MIDTHREL="N"). This record is linked to row 9 via the MIGRPID value of 1 to relate the metastasis to the finding at the primary site identified for the tumor.
Row 12:This record illustrates another metastasis row for the lymphoma found in multiple sites. This record is related to rows 10 and 13 via the MIGRPID value of 2.
Row 13:This record is an example of how to represent an unknown primary site for the lymphoma found in the uterus and vagina (row 11). The sponsor applicant decided to include a row to represent the base tumor (TFSPEC="SITE, UNCERTAIN PRIMARY") related to the metastasis row via the MIGRPID of 2, and defining it as the cause of death (MIDTHREL="Y"). Note: The use of "SITE, UNCERTAIN PRIMARY" is sponsorapplicant-specific; an alternative (based on how the data are collected) would be to exclude this row and only include rows for each site at which the tumor was found.
Rows 14-15:These findings demonstrates an original result with modifiers, including a severity which is copied into MISEV. The base pathological process is entered into MISTRESC using the controlled terminology list and the remaining modifiers are recorded in MIRESMOD ("Mononuclear Cell" for line 14) and MIDISTR ("Multifocal" for line 15) in the SUPPMI example.
Rows 16-17:These findings demonstrate the use of specimen location qualifiers of MIANTREG, MILAT, and MIDIR.
Row 18:This finding demonstrates the use of finding qualifiers MICHRON, MIDISTR, and MIRESMOD, and the use of a semicolon to separate 2 terms in MIRESMOD (SUPPMI example).
Row 19:This record is an example of an incidental malignant neoplasm in the liver that has not metastasized. The MIDTHREL is "N" because the tumor is incidental.
Dataset2
RowSTUDYIDDOMAINUSUBJIDMISEQMIGRPIDMISPIDMISTESTCDMITESTCDMITESTMIORRESMISTRESCMICHRONMIDISTRMIRESCATMISTATMIREASNDMISPECMIANTREGMISPCCNDMISPCUFLMILATMIDIRMISEVMIDTHRELMIDTCMIDY
1123MI123-011MIEXAM

GHISTXQLGeneral Histopathologic Exam, QualMicroscopic ExaminationAmyloidosis, grade 2AMYLOID

NON-NEOPLASTIC

TESTIS/EPIDIDYMIS




MILD
2015-10-27365
2123MI123-012MIEXAM

GHISTXQLGeneral Histopathologic Exam, QualMicroscopic ExaminationInflammation, acute, grade 2INFLAMMATIONACUTE
NON-NEOPLASTIC

TESTIS/EPIDIDYMIS




MILD
2015-10-27365
3123MI123-013MIEXAM

GHISTXQLGeneral Histopathologic Exam, QualMicroscopic ExaminationDegeneration/regeneration, myofiber, grade 4DEGENERATION/ REGENERATION

NON-NEOPLASTIC

MUSCLE, SKELETAL




MARKED
2015-10-27365
4123MI123-014MIEXAM

GHISTXQLGeneral Histopathologic Exam, QualMicroscopic Examination




NOT DONETissue not present for histologic examination no glandular tissue in sectionGLAND, MAMMARY






2015-10-27365
5123MI123-015MIEXAM

GHISTXQLGeneral Histopathologic Exam, QualMicroscopic ExaminationNormalUNREMARKABLE




GLAND, PARATHYROID






2015-10-27365
6123MI123-026MIEXAM

GHISTXQLGeneral Histopathologic Exam, QualMicroscopic ExaminationInflammation, meninges, grade 5INFLAMMATION

NON-NEOPLASTIC

BRAIN




SEVEREY2015-05-15200
7123MI123-037MIEXAM

GHISTXQLGeneral Histopathologic Exam, QualMicroscopic ExaminationHyperplasia, endometrial cystic, grade 3HYPERPLASIA

NON-NEOPLASTIC

UTERUS




MODERATE
2015-10-27365
8123MI123-038
MASS 1MIEXAMGHISTXQLGeneral Histopathologic Exam, QualMicroscopic ExaminationAdenoma: tubulostromal (benign neoplasm), leftADENOMA, TUBULOSTROMAL, BENIGN

BENIGN

OVARY


LEFT

N2015-10-27365
9123MI123-0391MASS 2MIEXAMGHISTXQLGeneral Histopathologic Exam, QualMicroscopic ExaminationSarcoma: endometrial stromal (malignant neoplasm), PrimarySTROMAL SARCOMA, ENDOMETRIAL, MALIGNANT

MALIGNANT

UTERUS





N2015-10-27365
10123MI123-03102MIEXAM
GHISTXQLGeneral Histopathologic Exam, QualMicroscopic ExaminationLymphoma: metastasisLYMPHOMA, MALIGNANT

METASTATIC

UTERUS





U2015-10-27365
11123MI123-03111MASS 3MIEXAMGHISTXQLGeneral Histopathologic Exam, QualMicroscopic ExaminationSarcoma: metastasis; Uterus was the primary siteSARCOMA, MALIGNANT

METASTATIC

VAGINA





N2015-10-27365
12123MI123-03122MIEXAM
GHISTXQLGeneral Histopathologic Exam, QualMicroscopic ExaminationLymphoma: metastasisLYMPHOMA, MALIGNANT

METASTATIC

VAGINA





U2015-10-27365
13123MI123-03132MIEXAM
GHISTXQLGeneral Histopathologic Exam, QualMicroscopic ExaminationLymphoma: multicentricLYMPHOMA, MALIGNANT

MALIGNANT

SITE, UNCERTAIN PRIMARY





Y2015-10-27365
14123MI123-0414MIEXAM

GHISTXQLGeneral Histopathologic Exam, QualMicroscopic ExaminationInfiltrate, mononuclear cell, grade 1INFILTRATE

NON-NEOPLASTIC

MENINGES




MINIMAL
2015-10-27365
15123MI123-0415MIEXAM

GHISTXQLGeneral Histopathologic Exam, QualMicroscopic ExaminationAtrophy, multifocal, grade 2ATROPHY
MULTIFOCALNON-NEOPLASTIC

TESTIS




MILD
2015-10-27365
16123MI123-0416MIEXAM

GHISTXQLGeneral Histopathologic Exam, QualMicroscopic ExaminationIntra-alveolar hemorrhage, right, grade 2HEMORRHAGE

NON-NEOPLASTIC

LUNGCRANIAL LOBE

RIGHT
MILD
2015-10-27365
17123MI123-0417MIEXAM

GHISTXQLGeneral Histopathologic Exam, QualMicroscopic ExaminationCyst, right, anteriorCYST

NON-NEOPLASTIC

KIDNEY


RIGHTANTERIOR

2015-10-27365
18123MI123-0518MIEXAM

GHISTXQLGeneral Histopathologic Exam, QualMicroscopic ExaminationInflammation, moderate, chronic, multifocal, mucosal, forestomach, grade 3INFLAMMATIONCHRONICMULTIFOCALNON-NEOPLASTIC

STOMACH




MODERATE
2015-10-27365
19123MI123-0619MIEXAM

GHISTXQLGeneral Histopathologic Exam, QualMicroscopic ExaminationHepatocellular carcinoma (malignant neoplasm without metastasis), incidentalCARCINOMA, HEPATOCELLULAR, MALIGNANT

MALIGNANT

LIVER





N2015-10-07345

...