This example shows the representation of circumferential and longitudinal strain findings in the CV domain. The sponsor used the "CMRBRANDTYP Feature Tracking" analysis method (CVANMETH).
See questions highlighted in red/orange.
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- Is row 4 to delineate between 2D/3D/4D strain analysis LV chamber views? no
- Question for Jon Neville - does ANMETH fit for the place to put the chamber view ofr the MR visualization? - not the right analysis method. The analysis method is related to the intrinsic algorithm performed by the MRI/CMR machine. It is important to know what method was used. These are types of "Feature Tracking".
- Would it be better to show one segment across the different dimensional chamber views at 2 or 3 timepoints? 1, 2, 5 yr point - could do one with change and one without change. Whenever do an MRI - do this; all data can allow feature tracking strain
- Is there a best terminology to use for the dimensions? check CT, 2D, 3D, 4D OR two-dimensional, three-dimensional, four-dimensional (2D is peak radial strain; 3D is peak circumferential strain, 4D is peak longitudinal strain..... is "peak" assumed or does that need to be there?)- not out clinically, more experimentally.
- What test is used to measure fibrosis - is it LGE or strain? May use strain if you think may see... LGE is the answer. Strain is a marker of actual function. It worsens before the LVEF
- (normal - -18 to 20) - -9 is poor
- The LV Global is the average of base/mid/apex circumferential readings/values.
- Longitudinal strain normal is -18%
- LV Global Longitudinal strain is the average of LV 4, 3, 2 chamber readings/values
-20 is a good result, -10 is a poor result. Could show change over time with first assessment normal, one example could have poor 1 year follow-up and the other can have stable cardiomyopathy disease. Or could just do this.
Circumferential and Longitudinal Strain are CMR measurement parameters used to evaluate progression of cardiac dysfunction.
SME add relatsionship to DMD
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Rows 1-3: | Show circumferential strain using the CMR Brand Type (CMRBRANDTYP) Feature tracking analysis for the left ventricular ventricle base, mid, and apex regions (CVLOC). | Row 4: | Shows the left ventricular global circumferential strain (CVLOC=LV Global) and (CVTEST=CIRCUMFERENTIAL STRAIN)circumferential strain for the LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENT. | Row 5: | Shows the global circumferential strain for the LV Basal Inferoseptal segment (CVLOC= LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENT). | Rows 6-8: | Show the longitudinal strain for 4 chamber, 3 chamber, and 2 chamber of the left ventricleviews. | Row 9: | Shows the left ventricular global longitudinal strain (CVLOC=LV Global) and (CVTEST=LONGITUDINAL STRAIN)longitudinal strain for the LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENT. | Row 10: | Shows global longitudinal strain for the left ventricular 4 chamber basal inferoseptal segment. - check this? was it left over or is correct? |
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Dataset2 |
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Row | STUDYID | DOMAIN | USUBJID | CVSEQ | CVTESTCD | CVTEST | CVORRES | CVORRESU | CVSTRESC | CVSTRESN | CVSTRESU | CVLOC | CVMETHOD | CVANMETH | CVLOBFXL | VISITNUM | VISIT | CVDTC |
| CVIMVIEW |
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1 | DMD-CLS | CV | DMD-CLS-01-401 | 1 | CFSTRAIN | CIRCUMFERENTIAL STRAINCARDIAC MAGNETIC RESONANCE IMAGING | Circumferential Strain | | % | | -9 | % | HEART, LEFT VENTRICLE, BASE |
OR LEFT VENTRICULAR BASE CURRENT CT HAS, HEART, RIGHT VENTRICLE, BASE AND HEART, RIGHT VENTRICLE, MID-LEVEL ***IT MAY BE A DIFFERENT USE CASE. CMRBRANDTYP Feature Tracking |
| 1 | SCREENINGVISIT 1 | 2023-09-01 |
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| 2 | DMD-CLS | CV | DMD-CLS-01-401 | 2 | CFSTRAIN | CIRCUMFERENTIAL STRAINCircumferential Strain | | % | | -12 | % | HEART, LEFT | VENTRICULAR CARDIAC MAGNETIC RESONANCE IMAGINGMRI | CMRBRANDTYP Feature tracking |
| 1 | SCREENINGVISIT 1 | 2023-09-01 |
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| 3 | DMD-CLS | CV | DMD-CLS-01-401 | 3 | CFSTRAIN | CIRCUMFERENTIAL STRAINCircumferential Strain | | % | | -10 | % | HEART, LEFT | VENTRICULAR CARDIAC MAGNETIC RESONANCE IMAGINGMRI | CMRBRANDTYP Feature tracking |
| 1 | SCREENINGVISIT 1 | 2023-09-01 |
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| 4 | DMD-CLS | CV | DMD-CLS-01-401 | 4 | CFSTRAIN | CIRCUMFERENTIAL STRAIN101010% GLOBALBASAL INFEROSEPTAL SEGMENT | MRI | CARDIAC MAGNETIC RESONANCE IMAGING | CMRBRANDTYP Feature tracking |
| 1 | SCREENINGVISIT 1 | 2023-09-01 |
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| 5 | DMD-CLS | CV | DMD-CLS-01-401 | 5 |
CFSTRAIN | GCS | Global Circumferential Strain | CIRCUMFERENTIAL STRAIN121212LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING | CMRBRANDTYP Feature tracking |
| 1 | SCREENINGVISIT 1 | 2023-09-01 |
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| 6 | DMD-CLS | CV | DMD-CLS-01-401 | 6 | LNGSTRAINLONGITUDINAL STRAIN, 4 CHAMBERCARDIAC MAGNETIC RESONANCE IMAGING | MRI | CMRBRANDTYP Feature Tracking |
| 1 | SCREENINGVISIT 1 | 2023-09-01 |
| 4-CHAMBER | 7 | DMD-CLS | CV | DMD-CLS-01-401 | 7 | LNGSTRAINLONGITUDINAL STRAIN, 3 CHAMBERCARDIAC MAGNETIC RESONANCE IMAGING | MRI | CMRBRANDTYP Feature tracking |
| 1 | SCREENINGVISIT 1 | 2023-09-01 |
| 3-CHAMBER | 8 | DMD-CLS | CV | DMD-CLS-01-401 | 8 | LNGSTRAINLONGITUDINAL STRAIN, 2 CHAMBERCARDIAC MAGNETIC RESONANCE IMAGING | MRI | CMRBRANDTYP Feature tracking |
| 1 | SCREENINGVISIT 1 | 2023-09-01 |
| 2-CHAMBER | 9 | DMD-CLS | CV | DMD-CLS-01-401 | 9 | LNGSTRAINLONGITUDINAL STRAIN181818 GLOBALBASAL INFEROSEPTAL SEGMENT | MRI | CARDIAC MAGNETIC RESONANCE IMAGING | CMRBRANDTYP Feature tracking |
| 1 | SCREENINGVISIT 1 | 2023-09-01 |
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| 10 | DMD-CLS | CV | DMD-CLS-01-401 | 10 |
LNGSTRAIN | LGS | Global Longitudinal Strain | LONGITUDINAL STRAIN141414LEFT VENTRICULAR 4 CHAMBER BASAL INFEROSEPTAL SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING | CMRBRANDTYP Feature tracking |
| 1 | SCREENING |
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| Variable | Label | Type | Role | Origin |
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| Imaging View | text | Non-standard Record Qualifier | CRF |
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