This example shows the representation of circumferential and longitudinal strain findings in the CV domain. The sponsor used the "CMRBRANDTYP Feature Tracking" analysis method (CVANMETH).
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- Is row 4 to delineate between 2D/3D/4D strain analysis LV chamber views?
- Question for Jon Neville - does ANMETH fit for the place to put the chamber view ofr the MR visualization?
- Would it be better to show one segment across the different dimensional chamber views at 2 or 3 timepoints? 1, 2, 5 yr point - could do one with change and one without change. Whenever do an MRI - do this; all data can allow feature tracking strain
- Is there a best terminology to use for the dimensions? check CT, 2D, 3D, 4D OR two-dimensional, three-dimensional, four-dimensional (2D is peak radial strain; 3D is peak circumferential strain, 4D is peak longitudinal strain..... is "peak" assumed or does that need to be there?)- not out clinically, more experimentally.
- What test is used to measure fibrosis - is it LGE or strain? May use strain if you think may see... LGE is the answer. Strain is a marker of actual function. It worsens before the LVEF
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-20 is a good result, -10 is a poor result. Could show change over time with first assessment normal, one example could have poor 1 year follow-up and the other can have stable cardiomyopathy disease. Or could just do this.
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| Rowcaps |
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| Rows 1-3: | Show circumferential strain |
with a 3 dimensional chamber view (CVANMETH) of the left ventricular basal anterior segment, left ventricular basal anteroseptal segment, and left ventricular basal inferoseptal segment (CVLOC)| for the left ventricle base, mid, and apex regions. | | Row 4: |
? - delete? If yes, shall we delete the 4D in the location of rows 5 & 6? | | Shows circumferential strain for the LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENT. | | Row 5: | Shows global circumferential strain. | | Rows 6-8: | Show longitudinal strain for 4 chamber, 3 chamber, and 2 chamber views. | | Row 9: | Shows longitudinal strain for the LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENT. | | Row 10: | Shows global longitudinal strain |
Rows 5-6: | Show circumferential strain with a 4 dimensional chamber view of the left ventricular basal inferoseptal segment and the left ventricular mid inferoseptal segment |
| Dataset2 |
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Row | STUDYID | DOMAIN | USUBJID | CVSEQ | CVTESTCD | CVTEST | CVORRES | CVORRESU | CVSTRESC | CVSTRESN | CVSTRESU | CVLOC | CVMETHOD | CVANMETH | CVLOBFXL | VISITNUM | VISIT | CVDTC |
| CVIMVIEW |
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| 1 | DMD-CLS | CV | DMD-CLS-01-401 | 1 | CFSTRAIN |
CIRCUMFERENTIAL STRAIN | -20 (normal - -18 to 20) -LV HEART, LEFT VENTRICLE, BASE |
CARDIAC MAGNETIC RESONANCE IMAGING| MRI | CMRBRANDTYP Feature Tracking |
- make is generic (specify the software program used - Medis/Circle/HeartIT as example, add more)SCREENING| VISIT 1 | 2023-09-01 |
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| | 2 | DMD-CLS | CV | DMD-CLS-01-401 | 2 | CFSTRAIN |
CIRCUMFERENTIAL STRAIN| Circumferential Strain | | % | | -12 | % |
LV | HEART, LEFT VENTRICLE, MID |
CARDIAC MAGNETIC RESONANCE IMAGING | Medis feature SCREENING| VISIT 1 | 2023-09-01 |
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| | 3 | DMD-CLS | CV | DMD-CLS-01 |
LV APEX | LV Global (average of base/mid/apex | | -401 | 3 | CFSTRAIN | Circumferential Strain | | % | | -10 | % | HEART, LEFT VENTRICLE, APEX | MRI | CMRBRANDTYP Feature tracking |
| 1 | VISIT 1 | 2023-09-01 |
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| | 4 |
33CIRCUMFERENTIAL STRAIN| Circumferential Strain | | % | | -12 | % | LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENT |
CARDIAC MAGNETIC RESONANCE IMAGING | | MRI | CMRBRANDTYP Feature tracking |
| 1 | VISIT 1 | 2023-09-01 |
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| | 5 | DMD-CLS | CV | DMD-CLS-01-401 | 5 | GCS | Global Circumferential Strain | | % | | -10 | % | HEART, LEFT VENTRICLE | MRI | CMRBRANDTYP Feature |
Medis feature SCREENING44 | LNGSTRAIN | | 6 | LOSTRAIN | Longitudinal Strain | | % |
LONGITUDINAL STRAIN - (normal) | CARDIAC MAGNETIC RESONANCE IMAGING | Medis feature tracking | 1 | | -18 | % | | MRI | CMRBRANDTYP Feature Tracking |
| 1 | VISIT 1 | 2023-09-01 |
| 4-CHAMBER | | 7 | DMD-CLS | CV | DMD-CLS-01-401 | 7 | LOSTRAIN | Longitudinal Strain | | % | | -20 | % | | MRI | CMRBRANDTYP Feature tracking |
| 1 | VISIT 1 |
SCREENINGLONGITUDINAL STRAIN | Medis feature tracking | LONGITUDINAL STRAIN | | Medis feature tracking | LONGITUDINAL STRAIN | Global (average of 4,3,2) | Medis feature tracking | | | 8 | DMD-CLS | CV | DMD-CLS-01-401 | 8 | LOSTRAIN | Longitudinal Strain | | % | | -15 | % | | MRI | CMRBRANDTYP Feature tracking |
| 1 | VISIT 1 | 2023-09-01 |
| 2-CHAMBER | | 9 |
55LNGSTRAINLONGITUDINAL STRAIN| Longitudinal Strain | | % | | -14 | % | LEFT VENTRICULAR |
4 CHAMBER | BASAL INFEROSEPTAL SEGMENT |
CARDIAC MAGNETIC RESONANCE IMAGING | | MRI | CMRBRANDTYP Feature tracking |
| 1 | VISIT 1 | 2023-09-01 |
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| | 10 | DMD-CLS | CV | DMD-CLS-01-401 | 10 | LGS | Global Longitudinal Strain | | % | | -18 | % | HEART, LEFT VENTRICLE | MRI | CMRBRANDTYP Feature |
Medis feature SCREENING |
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| Variable | Label | Type | Role | Origin |
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| Imaging View | text | Non-standard Record Qualifier | CRF |
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