Aortic Aneurysms in the aorta are classified based on their anatomical locations. Largely, they can be divided into two classes: thoracic aortic aneurysm (TAA), those that are in the thoracic aorta, and abdominal aortic aneurysm (AAA), those that are in the abdominal aorta.
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Thoracic aortic aneurysm (TAA) can further be divided into:
- Aortic root aneurysm
- Ascending aortic aneurysm
- Aortic arch aneurysm
- Descending aortic aneurysm
- Aneurysm that straddles multiple portions of the aorta (i.e. from aortic arch to descending aorta)
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Abdominal aortic aneurysm (AAA) can AAA can be classified as:
- Suprarenal aortic aneurysm: above the kidneys
- Infrarenal aortic aneurysm: below the kidneys.
- Others: Pararenal, Jaxtarenal aortic aneurys.
Most patients with aortic aneurysms (AA) are asymptomatic at the time of diagnosis, because the aneurysms are typically discovered incidentally on imaging studies. When an AA reaches medium to large size (>5cm), symptoms may manifest.
Symptoms for TAA are: patients may suffer a local mass effect, such as compression of the trachea or mainstem bronchus (if in the area of the lungs, will cause cough, dyspnea, wheezing, or recurrent pneumonitis), compression of the esophagus (causing dysphagia), or compression of the recurrent laryngeal nerve (causing hoarseness). Chest pain, generally described as deep and aching or throbbing.
Symptoms of AAA are: pain in the chest, abdomen, lower back, or flank (over the kidneys). A pulsating feeling in the abdomen. A "cold foot" or a black or blue painful toe.
The patient had undergone a diagnostic intervention, during which a CT scan was done on the chest and abdomen of the subject. The CT scan created images of the thoracic and abdominal regions. An evaluator then reviewed the images of the thoracic region and abdominal region, to find whether aneurysms and arterial dissections are present and where they are located.
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| TAA and AAA concept map 2 |
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| TAA and AAA concept map 2 |
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When a patient has abdominal aortic aneurysm of a substantial size, the patient may also have synchronous and metachronous thoracic aortic aneurysm. If causes and conditions are present to create an aneurysm in a large-medium size vessel in one place, you are more likely than those without those causes and conditions to have (or develop) another aneurysm somewhere.Case 1 - Subject has both TAA and AAA
The subject had CT scans performed at on the chest and abdomen.
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Row | STUDYID | DOMAIN | USUBJID | PRSEQ | PRTRT | PRLOC | VISIT |
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| 1 | ABC | PR | ABC-123 | 1 | CT SCAN | CHEST | BASELINE |
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| 2 | ABC | PR | ABC-123 | 2 | CT SCAN | ABDOMEN | BASELINE |
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An evaluator examines the images of the thoracic and abdominal regions produced by the CT scan and decides whether TAA and AAA are present as well as their location. Modeling both TAA and AAA in the CV domain, note for viewing simplicity, some variables are omitted from the table below.
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| Row 1: | I examined the image of the thoracic |
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cavity | region (test location) and found an aneurysm in the Thoracic Aorta (result location) spanning from the aortic arch to the descending aorta (result location detail). In this case result location detail further qualifies both ORRES and RESLOC, hence this is a variable qualifier. | | Row 2: | I measured the diameter of the aneurysm from aortic arch to the descending |
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aortic aneurysm| aorta (test location). | | Row 3: | I examined the image of the thoracic |
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cavity | region (test location) and found |
out | that the descending aorta (result location) had severely dissected (the artery is tore and a false lumen had formed), most likely due to the enormous pressure caused by the large aneurysm in this area. | | Row 4: | The dissected descending aorta (test location) is classified based on the Stanford Aortic Dissection System as type B. |
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| Row 5: | I examined the image of the abdominal |
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cavity | region (test location) and found an aneurysm in the infrarenal aorta (result location), proximal to the iliac bifurcation (result location detail). In this case result location detail is a variable qualifier for the result, I am trying to say that the aneurysm is located in the segment of the infrarenal aorta closer (proximal) to the iliac bifurcation. | | Row 6: | I measured the diameter of the infrarenal aortic (test location) aneurysm. |
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| Row 7: | I examined the image of the abdominal |
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cavity out | that the infrarenal aorta (result location) had dissected. |
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Row | STUDYID | DOMAIN | USUBJID | CVSEQ | CVGRPID | CVTEST | CVORRES | CVORRESUCVORRESU | CVLOC | CVLOCDTL | CVMETHOD | VISITNUM | VISIT | CVDTC |
| CVRESLOC
| CVRESLOC Detail |
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| 1 | ABC | CV | ABC-123 | 1 | 1 | Aneurysm Indicator | Y |
| Thoracic Cavityregion |
| CT SCAN | 1 | BASELINE | 2020-04-27 |
| Thoracic Aorta | Aortic Arch to Descending Aortaaorta |
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| 2 | ABC | CV | ABC-123 | 2 | 1 | Aneurysm Diameter | 6 | cm | Thoracic Aorta | Aortic Arch to Descending Aortaaorta | CT SCAN | 1 | BASELINE | 2020-04-27 |
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| 43 | ABC | CV | ABC-123 | 43 | 2 | Dissection Indicator | Y |
| Thoracic Cavityregion |
| CT SCAN | 1 | BASELINE | 2020-04-27 |
| Descending Aortaaorta |
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| 64 | ABC | CV | ABC-123 | 64 | 2 | Stanford AoD Classification | Stanford B |
| Descending Aortaaorta |
| CT SCAN | 1 | BASELINE | 2020-04-27 |
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| 75 | ABC | CV | ABC-123 | 75 | 3 | Aneurysm Indicator | Y |
| Abdominal Cavityregion |
| CT SCAN | 1 | BASELINE | 2020-04-27 |
| Infrarenal aorta | proximal to the iliac bifurcation |
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| 86 | ABC | CV | ABC-123 | 86 | 3 | Aneurysm Diameter | 7 | cm | Infrarenal aorta | proximal to the iliac bifurcation | CT SCAN | 1 | BASELINE | 2020-04-27 |
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| 107 | ABC | CV | ABC-123 | 107 |
| Dissection Indicator | Y |
| Abdominal Cavityregion |
| CT SCAN | 1 | BASELINE | 2020-04-27 |
| Infrarenal aorta | proximal to the iliac bifurcation |
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Case 2 - Subject has AAA but TAA is not found
The subject had CT scans a MRI performed at the chest and abdomenon the torso (trunk).
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| Dataset2 |
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Row | STUDYID | DOMAIN | USUBJID | PRSEQ | PRTRT | PRLOC | VISIT |
| PRLOC1 | PRLOC2 |
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| 1 | ABC | PR | ABC-456 | 1 | CT SCANMRI | CHESTMultiple | BASELINE | 2
| Chest | ABC | PR | ABC-456 | 2 | CT SCAN | ABDOMEN | BASELINE | Abdomen |
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The MRI scan produced images about the thoracic and abdominal regions of the subject. The evaluator then examined the MRI images of the thoracic region and abdominal region, and found the presence of a large AAA, but Modeling the presence of AAA and the absence of TAA in CV.
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| Row 1: | I examined the MRI image of the thoracic region (test location) and didn't find the presence of an aneurysm. |
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| Row 2: | I examined the MRI image of the abdominal region (test location) and found an aneurysm in the left (Result LAT) renal artery (Result Loc). |
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| Row 3: | I examined the image of the abdominal region (test location) and found an aneurysm in the infrarenal aorta (Result Loc). |
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| Row 4: | I measured the diameter of the aneurysm in the left renal artery (test location). |
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| Row 5: | I measured the diameter of the aneurysm in the Infrarenal Aorta (test location). |
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| Dataset2 |
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Row | STUDYID | DOMAIN | USUBJID | CVSEQ | CVGRPID | CVTEST | CVORRES | CVORRESUCVORRESU | CVLOC | CVLAT | CVMETHOD | VISITNUM | VISIT | CVDTC |
| CVRESLOC
| CVRESLAT |
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| 1 | ABC | CV | ABC-456 | 1 |
| Aneurysm Indicator | N |
| Thoracic CavityRegion |
| CT SCANMRI | 1 | BASELINE | 2020-04-27 |
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| 2 | ABC | CV | ABC-456 | 2 | 1 | Aneurysm Indicator | Y | Thoracic Cavity |
| Abdominal Region |
| MRICT SCAN | 1 | BASELINE | 2020-04-27 |
| Renal Artery | Left |
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| 3 | ABC | CV | ABC-456 | 3 | 2 | Aneurysm Indicator | Y | Thoracic Cavity |
| Abdominal Region |
| MRICT SCAN | 1 | BASELINE | 2020-04-27 |
| Infrarenal Aorta |
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| 54 | ABC | CV | ABC-456 | 54 | 1 | Aneurysm Diameter | 23 | cm | Renal Artery | Left | CT SCANMRI | 1 | BASELINE | 2020-04-27 |
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| 65 | ABC | CV | ABC-456 | 65 | 2 | Aneurysm Diameter | 5 | cm | Infrarenal Aorta |
| CT SCANMRI | 1 | BASELINE | 2020-04-27 |
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