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This crossmulti-domain example shows domain example shows a PC domain for a rodent sparse sampling study of 9 animal subjects, where all timing information was readily available electronically. The subjects were dosed daily and sampled to construct 2 time-concentration profiles, with one referencing the day 1 dose and the other referencing the day 42 dose. The concentration data were then combined by reference dose (day 1 or day 42) to create composite rat exposures in the PP domain.

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In this example, even though all subjects in the pool shared the same date as the reference time point for the profile, the sponsor applicant chose to leave PPRFTDTC as null.

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