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•  Add text to say that the MB domain is used for the characterization, detection and identification of the non-host microorganism, so data pertain to the host immune response to the non-host microorganism should not be mapped into this domain

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•  MB is used for the direct assessment of the non-host microorganism, through detection of the microbial antigen, genetic martial (nucleic acids), toxin, etc. Anti-microbial antibodies are indirect, surrogate measures to detect a non-host microorganism that may or may not even be there at the time of the test, and therefore had been remodeled in IS since 3.4.