Versions Compared

Key

  • This line was added.
  • This line was removed.
  • Formatting was changed.
  • T1 levels are elevated in patients with DMD, compared to healthy individuals.
  • "Both native and post-contrast T1 and ECV estimates are promising diagnostic CMR biomarkers for assessing myocardial remodeling in Duchenne muscular dystrophy."
  • "Additionally, from pre- and post-contrast T1 measurements (and if the patient’s hematocrit is measured), the extracellular volume (ECV) fraction can be calculated and used to quantify diffuse fibrosis."
  • "Elevated myocardial ECV in DMD subjects compared to healthy controls has been shown by multiple studies , thus ECV is promising as a quantitative metric for detecting myocardial microstructural remodeling."

(ref: https://jcmr-online.biomedcentral.com/articles/10.1186/s12968-020-00687-z)

The following SDTM example shows parametric mapping (T1, T2, and extracellular volume) results. For brevity, a limited sample of tests after contrast are shown in this example. The example includes some device information (i.e., device manufacturer, software, version information, and the specific settings for each subject); however, study requirements will determine what data should be included.

Example

Include Page
SDTM. Parametric Mapping
SDTM. Parametric Mapping

...