- T1 levels are elevated in patients with DMD, compared to healthy individuals.
- "Both native and post-contrast T1 and ECV estimates are promising diagnostic CMR biomarkers for assessing myocardial remodeling in Duchenne muscular dystrophy."
- "Additionally, from pre- and post-contrast T1 measurements (and if the patient’s hematocrit is measured), the extracellular volume (ECV) fraction can be calculated and used to quantify diffuse fibrosis."
- "Elevated myocardial ECV in DMD subjects compared to healthy controls has been shown by multiple studies , thus ECV is promising as a quantitative metric for detecting myocardial microstructural remodeling."
(ref: https://jcmr-online.biomedcentral.com/articles/10.1186/s12968-020-00687-z)
The following SDTM example shows parametric mapping (T1, T2, and extracellular volume) results. For brevity, a limited sample of tests after contrast are shown in this example. The example includes some device information (i.e., device manufacturer, software, version information, and the specific settings for each subject); however, study requirements will determine what data should be included.
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