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The computed total score consists of integer values ranging from 0 to 71. The classification system consists of 11 physiology measures based on a numeric rating scale 0 to 4 where 0 reflects values within the normal range and an increase in the numeric rating scale represents an increase in the abnormality of the physiology measure in either the high or low direction. For Serum Creatinine, the measure is assessed on the same scale but double points are assigned for subjects with acute renal failure. The measure evaluating extent of impaired consciousness is calculated as 15 minus the Glasgow Coma Scale (GCS) Score, so that lower scores indicate mild or no impairment and higher scores represent more severe impairment (possible head and/or central nervous system injury) and range from 0 to 12. Chronological age is divided into age groups which are assigned values of 0, 2, 3, 5, or 6. For subjects with a history of severe organ system insufficiency or who are immunocompromised, a numeric rating of 2 or 5 is assigned for chronic health points, where 2 is assigned “for elective postoperative subjects” and 5 is assigned “for nonoperative or emergency postoperative subjects”. For subjects who do not have a history of severe organ system insufficiency or who are not immunocompromised, a NOT DONE record may be retained from the source RS domain with the conditional branching flag (RSCBRFL="Y") populated. Additionally, a sponsor may choose to set AVAL=0 for subjects who are "healthy" or do not meet the criteria for assigning chronic health points. This decision must be clearly documented, as the analysis value of 0 is logically derived or implied.

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