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TSVALNF contains a “null flavor,” a value that provides additional coded information when TSVAL is null. For example, for TSPARM = "AGEMAX" (Planned Maximum Age of Subjects), there is no value if a study does not specify a maximum age. In this case, the appropriate null flavor is "PINF", which stands for "positive infinity." In TSVALNF can also be used in a case where the value of a particular parameter is unknown.   However, in a tobacco study conducted in healthy volunteers where the trial phase classification is not established, the value (TSVAL) for TSPARM = "TPHASE" would be "NOT APPLICABLE". TSVAL should not be left null in this case.

Sequence number is given to ensure uniqueness within a parameter. In this example, TSPARMCD (FCNTRY) is repeated twice to indicate that the study was conducted in the US and Canada. TSSEQ is assigned "1" for the US and "2" for Canada.   

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