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The Acute Physiology and Chronic Health Evaluation (APACHE II) is a severity of disease measurement and mortality estimation tool for adult patients applied within 24 hours of admission to an intensive care unit (ICU). The instrument's intended use is for newly admitted patients to the ICU. The instrument consists of individual items that are summed up to create a total score. This instrument is generally collected once at Screening/Baseline and used as a predictor of mortality rather than an outcome measure. The total score is normally collected as part of the instrument with no instructions provided for handling missing data. In the majority of cases, where APACHE II is only assessed once and the collected total score used as a baseline covariate, the SDTM RS domain may be sufficient to support the analysis requirements, as a variable in ADSL copied directly from a result/value in SDTM.

The APACHE II total score is designed as a mortality prediction tool. It is not intended to influence the medical management or care of patients during their ICU stay or to be calculated sequentially to show improvement or effect of interventions. The worst values recorded during the initial 24 hours in the ICU are recommended to be used to calculate in calculation of the total score but alternatively, the measurements initially recorded during the patient’s admission can be used for practical reasons. 

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