See questions highlighted in red/orange.
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- Is row 4 to delineate between 2D/3D/4D strain analysis LV chamber views? no
- Question for Jon Neville - does ANMETH fit for the place to put the chamber view ofr the MR visualization? - not the right analysis method. The analysis method is related to the intrinsic algorithm performed by the MRI/CMR machine. It is important to know what method was used. These are types of "Feature Tracking".
- Would it be better to show one segment across the different dimensional chamber views at 2 or 3 timepoints? 1, 2, 5 yr point - could do one with change and one without change. Whenever do an MRI - do this; all data can allow feature tracking strain
- Is there a best terminology to use for the dimensions? check CT, 2D, 3D, 4D OR two-dimensional, three-dimensional, four-dimensional (2D is peak radial strain; 3D is peak circumferential strain, 4D is peak longitudinal strain..... is "peak" assumed or does that need to be there?)- not out clinically, more experimentally.
- What test is used to measure fibrosis - is it LGE or strain? May use strain if you think may see... LGE is the answer. Strain is a marker of actual function. It worsens before the LVEF
- (normal - -18 to 20) - -9 is poor
- The LV Global is the average of base/mid/apex circumferential readings/values.
- Longitudinal strain normal is -18%
- LV Global Longitudinal strain is the average of LV 4, 3, 2 chamber readings/values
-20 is a good result, -10 is a poor result. Could show change over time with first assessment normal, one example could have poor 1 year follow-up and the other can have stable cardiomyopathy disease. Or could just do this.
Circumferential and Longitudinal Strain are CMR measurement parameters used to evaluate progression of cardiac dysfunction.
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