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"T1 mapping stands for registering the course of recovery of longitudinal magnetism", this means the relaxation time after either the preparation step (saturation or inversion prepulse) followed by the acquisition of images at several time points during the T1 recover/relaxation. T1 value represents the time when recovery of magnetism has reached a percentage of its original state (63%). The recovery rate relates to the myocardial tissue properties that may be altered by pathological tissue presence (https://www.ahajournals.org/doi/10.1161/circresaha.116.307974). T1 mapping values increase with disease, and decrease post contrast.

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For extracellular volume - use percent. Normal is under 28.5%; Abnormal is in the mid 30%; mid 20% 

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Post contrast longitudinal relaxation time is 400s to 500s

Post contrast transverse relaxation time is not done

Stopped here -

1. Do we need timepoints for the T1 measurement or just the point in time of the final assessment? Not applicable
   
2. Does Cardiac Motion correction need to be indicated? If yes, does the type need to be indicated (such as the modified LL (MOLLI) sequence)?  If yes, should this be reflected on each result? (Alana/Jon/Diane - I am considering a "Cardiac Motion Correction Indicator" NSV if this is important)- MOLLI shMOLLI, SHASHA, too much in the weeds. not applicable.
3. Three is a "gold" standard noted as the "T1 mapping based on the acquisition of single images by a T1 turbo spin-echo sequence". It is noted as the ultimate T1 mapping method. Does the method need to be called out by what kind of acquisition sequence was used? NA
   
4. For the location does the intracellular compartment need to be noted? (myocytes, fibroblasts, endothelial cells, smooth muscle cells)
5. Does the cardiac phase for the specific T1 segment need to be noted? (atrial systole-diastole; isovolumentric contraction-diastole; rapid ejection-systole; reduced ejection-systole; isovolumetric relaxation-diastole; rapid ventricular filling-diastole) - NA, done in diastole
6. Is it important to record the "MRI scanner type" (Avanto, Siemens; Best, Philips; Acheiva, Philips), the "reception coil" (16-channel; 32-channel), "the T1 mapping sequence" (MOLLI; ShMOLLI)

The following example shows the parametric mapping (T1 mapping, T2 mapping, and extracellular volume) results for USUBJID 301. For brevity, after contrast a limited sample of tests were shown in this example.

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Changeable properties and parameters of the devices identified in DI are represented in the DU domain. These settings could be linked to the record in the CV domain by their shared SPDEVID and DTC values. For the sake of brevity, only 1 subject's parameters are shown. For more information on relating records, see SDTMIG v3.4 Section 8.2, Relating Peer Records. 

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Notes for discussion

Interslice Distance - aligns with "Gap"

A minimum of 12 slices were performed, with 20 phases/slice... ?

Imaging protocol - would this be put somewhere? It seems like it would be helpful - would a GRPID be used and then defined somewhere? Or, would it be in the study protocol and not required in the data. If aggregating across studies, it seems like it would be helpful to have it in the data.

Number of excitations =2 for breath hold; 4 to 5 for free breathing (what would this DUTEST be?)

Radiofrequency flip angles were set between 50 degrees and 70 degrees

Grid tag spacing was 7 to 8 mm

TE/TR = 3ms/6.6 ms (by type of machine)

views per segment = views/segment = 7 to 9  based on machine type (one was = 8)

Data analysis was via "standard planimetry techniques" using semi-automated computer software - this is where Medis is mentioned... is this perhaps what should be in ANMETH?  Do we have a definition for "Feature Tracking" (in the Circum and Long Strain examples)

https://www.jacc.org/doi/abs/10.1016/j.jacc.2008.12.032 - article is for strain - find one for CMR and Parametric mapping .... if different parameters.

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