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- What is the difference between T1 and T2? Should there be any differences in the data collected for each of these? one is longitudinal relaxation time and the other is transverse relaxation time. The results vary by the physics of the MRI. It shows how the protocns relax after a period of excitation. 1.5 Tesla has a different constant than for another type of scanner. It detects edema/fibrosis. Transverse relaxation time - under 49 change to 40 to 50; 50,60 is high.
- Do we need minimum and maximum values? for SI mean, area, circumference, SI mean, SI min/max?- will change depending on the (also changes after contrast)- NA; in the context of research do they collect this - no. Not relevant.
For extracellular volume - use percent. Normal is under 28.5%; Abnormal is in the mid 30%; mid 20% Post contrast longitudinal relaxation time is 400s to 500s Post contrast transverse relaxation time is not done
Stopped here - - Do we need timepoints for the T1 measurement or just the point in time of the final assessment?
- Does Cardiac Motion correction need to be indicated? If yes, does the type need to be indicated (such as the modified LL (MOLLI) sequence)? If yes, should this be reflected on each result? (Alana/Jon/Diane - I am considering a "Cardiac Motion Correction Indicator" NSV if this is important)
- Do we need a postcontrast indicator since those measurement differ? or is that what the terms "native T1" (no contrast) and "post-contrast T1" (after contrast) mean?
- Three is a "gold" standard noted as the "T1 mapping based on the acquisition of single images by a T1 turbo spin-echo sequence". It is noted as the ultimate T1 mapping method. Does the method need to be called out by what kind of acquisition sequence was used?
- For the location does the intracellular compartment need to be noted? (myocytes, fibroblasts, endothelial cells, smooth muscle cells)
- Does the cardiac phase for the specific T1 segment need to be noted? (atrial systole-diastole; isovolumentric contraction-diastole; rapid ejection-systole; reduced ejection-systole; isovolumetric relaxation-diastole; rapid ventricular filling-diastole)
- Is it important to record the "MRI scanner type" (Avanto, Siemens; Best, Philips; Acheiva, Philips), the "reception coil" (16-channel; 32-channel), "the T1 mapping sequence" (MOLLI; ShMOLLI)
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The PR dataset shows the procedure of cardiac magnetic resonance imaging using the device associated with SPDEVID ABC001 and the PRREFID of 12345678. This information shows what CMR device is used for the procedure and the accession number or procedure reference identifier associated with the specific procedure for USUBJID 301. The SPDEVID variable is used to relate records by the device (in this case, the CMR machine). The Device Identifier (DI) dataset holds the device information details.
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| Row | STUDYID | DOMAIN | USUBJID | SPDEVID | PRSEQ | PRREFID | PRLNKID | PRTRT | PRSTDTC |
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| 1 | DMD-RT | PR | 301 | ABC001 | 1 | 12345678 | 04 | CARDIAC MAGNETIC RESONANCE IMAGING | 2023-08-01 |
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The Cardiovascular System Findings (CV) dataset contains physiological and morphological findings related to the cardiovascular system so it holds the assessments from the parametric mapping. The CV dataset below shows how to represent longitudinal relaxation time, transverse relaxation time and extracellular volume findings from CMR.
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Rows 1-10: | Show the T1 Longitudinal Relaxation Time, the T2 Transverse Relaxation Time, Native T1 Mapping, and Extracellular volume for different segments of the heart prior to contrast for CMR. | Rows 11-13: | Show the T1 Longitudinal Relaxation Time, Native T1 Mapping, and Extracellular volume for different segments of the heart after contrast for CMR. |
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Row | STUDYID | DOMAIN | USUBJID | CVSEQ | CVTESTCD | CVTEST | CVCAT | CVORRES | CVORRESU | CVSTRESC | CVSTRESN | CVSTRESU | CVSTAT | CVREASND | CVLOC | CVMETHOD | CVLOBFXL | VISITNUM | VISIT | CVDTC |
| CVICNOIS | CVICMOTD | CVFOIIND | CVOIQ |
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| 1 | DMD-RT | CV | 301 | 1 | T1 | LONGITUDINAL RELAXATION TIME | | | ms | | 1315 | ms | | | LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 |
| LOW NOISE | NO MOTION DISTORTION | NO FOREIGN OBJECTS | EVALUABLE IMAGE | | 2 | DMD-RT | CV | 301 | 2 | T1 | LONGITUDINAL RELAXATION TIME | Pre-contrast | 1166 | ms | 1166 | 1166 | ms |
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| LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 |
| LOW NOISE | NO MOTION DISTORTION | NO FOREIGN OBJECTS | EVALUABLE IMAGE | | 3 | DMD-RT | CV | 301 | 3 | T1 | LONGITUDINAL RELAXATION TIME | | | ms | | 980 | ms |
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| LEFT VENTRICULAR BASAL INFERIOR SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 |
| LOW NOISE | NO MOTION DISTORTION | NO FOREIGN OBJECTS | EVALUABLE IMAGE | | 4 | DMD-RT | CV | 301 | 4 | T2 | TRANSVERSE RELAXATION TIME | | | ms | 45 | 45 | ms | | | LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 |
| LOW NOISE | NO MOTION DISTORTION | NO FOREIGN OBJECTS | EVALUABLE IMAGE | | 5 | DMD-RT | CV | 301 | 5 | T2 | TRANSVERSE RELAXATION TIME | | | ms | 40 | 40 | ms |
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| LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 |
| LOW NOISE | NO MOTION DISTORTION | NO FOREIGN OBJECTS | EVALUABLE IMAGE | | 6 | DMD-RT | CV | 301 | 6 | T2 | TRANSVERSE RELAXATION TIME | | | ms | 48 | 48 | ms |
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| LEFT VENTRICULAR BASAL INFERIOR SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 |
| LOW NOISE | NO MOTION DISTORTION | NO FOREIGN OBJECTS | EVALUABLE IMAGE | | 7 | DMD-RT | CV | 301 | 7 |
| NATIVE T1 MAPPING | Pre-contrast | 1070 | ms | | 1070 | ms |
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| CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 |
| LOW NOISE | NO MOTION DISTORTION | NO FOREIGN OBJECTS | NON-EVALUABLE IMAGE | | 8 | DMD-RT | CV | 301 | 8 | EXTRAVOL | EXTRACELLULAR VOLUME | | | /s | | 1.5 | /s | | | LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 |
| LOW NOISE | NO MOTION DISTORTION | NO FOREIGN OBJECTS | EVALUABLE IMAGE | | 9 | DMD-RT | CV | 301 | 9 | EXTRAVOL | EXTRACELLULAR VOLUME | | | /s | | 1.2 | /s |
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| LEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 |
| LOW NOISE | NO MOTION DISTORTION | NO FOREIGN OBJECTS | EVALUABLE IMAGE | | 10 | DMD-RT | CV | 301 | 10 | EXTRAVOL | EXTRACELLULAR VOLUME | | | /s | | 1.1 | /s |
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| LEFT VENTRICULAR BASAL INFERIOR SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 |
| LOW NOISE | NO MOTION DISTORTION | NO FOREIGN OBJECTS | EVALUABLE IMAGE | | 11 | DMD-RT | CV | 301 | 11 | T1 | LONGITUDINAL RELAXATION TIME | | | ms | 450 | 450 | ms | | | LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 |
| LOW NOISE | NO MOTION DISTORTION | NO FOREIGN OBJECTS | EVALUABLE IMAGE | | 12 | DMD-RT | CV | 301 | 12 |
| NATIVE T1 MAPPING | Post-contrast | 840 | ms | | 840 | ms |
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| CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 |
| LOW NOISE | NO MOTION DISTORTION | NO FOREIGN OBJECTS | EVALUABLE IMAGE | | 13 | DMD-RT | CV | 301 | 13 | EXTRAVOL | EXTRACELLULAR VOLUME | | | % | 25 | 25 | % | | | LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-01 |
| LOW NOISE | NO MOTION DISTORTION | NO FOREIGN OBJECTS | EVALUABLE IMAGE | | 1 | DMD-RT | CV | 302 | 1 | CVALL | CMR TEST RESULTS | |
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| | | | CARDIAC MAGNETIC RESONANCE IMAGING |
| 1 | SCREENING | 2023-08-05 |
| HIGH NOISE | YES-NOT ACCEPTABLE MOTION DISTORTION | YES FOREIGN OBJECTS | NON-EVALUABLE IMAGE |
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| Variable | Label | Type | Role | Origin |
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| CVICNOIS | Image Condition r/t Noise | text | Non-standard Record Qualifier | CRF | | CVICMOTD | Image Condition r/t Motion Distortion | text | Non-standard Record Qualifier | CRF | | CVFOIIND | Foreign Object on Image Indicator | text | Non-standard Record Qualifier | CRF | | CVOIQ | Overall Image Quality | text | Non-standard Record Qualifier | CRF |
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Notes for discussion Interslice Distance - aligns with "Gap" A minium minimum of 12 slices were performed, with 20 phases/slice... ? Imaging protocol - would this be put somewhere? It seems like it would be helpful - would a GRPID be used and then defined somewhere? Or, would it be in the study protocol and not required in the data. If aggregating across studies, it seems like it would be helpful to have it in the data. Number of excitations =2 for breath hold; 4 to 5 for free breathing (what would this DUTEST be?) Radiofrequency flip angles were set between 50 degrees and 70 degrees Grid tag spacing was 7 to 8 mm TE/TR = 3ms/6.6 ms (by type of machiine) views per segment = views/segment = 7 to 9 based on machine type (one was = 8)
Data analysis was via "standard planimetry techniques" using semi-automated computer software - this is where Medis is mentioned... is this perhaps what should be in ANMETH? Do we have a definition for "Feature Tracking" (in the Circum and Long Strain examples)
https://www.jacc.org/doi/abs/10.1016/j.jacc.2008.12.032 - article is for strain - find one for CMR and Parametric mapping .... if different parameters. |
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