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"T1 mapping stands for registering the course of recovery of longitudinal magnetism", this means the relaxation time after either the preparation step (saturation or inversion prepulse) followed by the acquisition of images at several time points during the T1 recover/relaxation. T1 value represents the time when recovery of magnetism has reached a percentage of its original state (63%). The recovery rate relates to the myocardial tissue properties that may be altered by pathological tissue presence (https://www.ahajournals.org/doi/10.1161/circresaha.116.307974). T1 mapping values increase with disease, and decrease post contrast.


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Do you we need minimum and maximum values? for SI mean, area, circumference, SI mean, SI min/max?

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Medis Medical Imaging

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urlhttps://www.youtube.com/watch?v=Cn5WyfYKIjc
  October 2022

T1 mapping in CMR, elevated T1 values  pointing to edematous tissue.

2 types of myocardial fibrosis - 1) interstitial , 2: replacement fibrosis (post MI), interstitial fibrosis subtypes - reactive and infiltrative fibrosis. Reactive: HT, DCM, volume/pressure overload; infilstrative: amyloid, Anderson Fabry

Diseases characterized by diffuse myocardial fibrosis cannot be evaluated by LGE since there are no reference regions of normal myocardium (Rosario J. Perea et al).

T1 mapping:

  1. A T1 map of the myocardium is a parametric reconstructed image
  2. Each pixel's intensity directly corresponds to the T1 relaxation time of the corresponding myocardial voxel.
  3. Quantification of diffuse myocardial fibrosis.
  4. Native T1 reflects myocardial disease involving the myocyte and interstitium.
  5. The use of gadolinium allows measurement of the extracellular volume fraction, reflecting interstitial space.

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urlhttps://www.youtube.com/watch?v=OeRUMBDez1A

TMT: Cardiac MRI: Value of T1 Mapping by Dr. Avanti Gulhane

Do we need timepoints for the T1 measurement or just the point in time of the final assessment?

Does Cardiac Motion correction need to be indicated? If yes, does the type need to be indicated (such as the modified LL (MOLLI) sequence)?  If yes, should this be reflected on each result? (Alana/Jon/Diane - I am considering a "Cardiac Motion Correction Indicator" NSV)

Do we need a postcontrast indicator since those measurement differ? or is that what the terms "native T1" (no contrast) and "post-contrast T1" (after contrast) mean?

Three is a "gold" standard noted as the "T1 mapping based on the acquisition of single images by a T1 turbo spin-echo sequence". It is noted as the ultimate T1 mapping method. Does the method need to be called out by what kind of acquisition sequence was used?

For the location does the intracellular compartment need to be noted? (myocytes, fibroblasts, endothelial cells, smooth muscle cells)

Does the cardiac phase for the specific T1 segment need to be noted? (atrial systole-diastole; isovolumentric contraction-diastole; rapid ejection-systole; reduced ejection-systole; isovolumetric relaxation-diastole; rapid ventricular filling-diastole)

Is it important to record the "MRI scanner type" (Avanto, Siemens; Best, Philips; Acheiva, Philips), the "reception coil" (16-channel; 32-channel), "the T1 mapping sequence" (MOLLI; ShMOLLI)



The following example shows the T1 mapping results for USUBJID 301.

Dataset2

Row

STUDYID

DOMAIN

USUBJID

CVSEQ

CVTESTCD

CVTEST

CVORRES

CVORRESU

CVSTRESC

CVSTRESN

CVSTRESU

CVLOC

CVMETHOD

CVLOBFXL

VISITNUM

VISIT

CVDTC

1DMD-RTCV3011T1LONGITUDINAL RELAXATION TIME

1315

ms

1315

1315ms

LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT

CARDIAC MAGNETIC RESONANCE IMAGING
1SCREENING2023-08-01
2DMD-RTCV3012T1LONGITUDINAL RELAXATION TIME1166ms11661166msLEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENTCARDIAC MAGNETIC RESONANCE IMAGING
1SCREENING2023-08-01
3DMD-RTCV3013T1LONGITUDINAL RELAXATION TIME

980

ms

980

980msLEFT VENTRICULAR BASAL INFERIOR SEGMENTCARDIAC MAGNETIC RESONANCE IMAGING
1SCREENING2023-08-01
4DMD-RTCV3014T2TRANSVERSE RELAXATION TIME

962

ms

962

962

ms

LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT

CARDIAC MAGNETIC RESONANCE IMAGING
1SCREENING2023-08-01
5DMD-RTCV3015T2TRANSVERSE RELAXATION TIME

976

ms

976

976

msLEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENTCARDIAC MAGNETIC RESONANCE IMAGING
1SCREENING2023-08-01
6DMD-RTCV3016T2TRANSVERSE RELAXATION TIME

985

ms

985

985msLEFT VENTRICULAR BASAL INFERIOR SEGMENTCARDIAC MAGNETIC RESONANCE IMAGING
1SCREENING2023-08-01
7DMD-RTCV3017
NATIVE T1 MAPPING1070ms

1070

1070ms
CARDIAC MAGNETIC RESONANCE IMAGING
1SCREENING2023-08-01
8DMD-RTCV3018EXTRAVOLEXTRACELLULAR VOLUME

1.5

/s

1.5

1.5/s

LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT

CARDIAC MAGNETIC RESONANCE IMAGING
1SCREENING2023-08-01
9DMD-RTCV3019EXTRAVOLEXTRACELLULAR VOLUME

1.2

/s

1.2

1.2/sLEFT VENTRICULAR BASAL INFEROSEPTAL SEGMENTCARDIAC MAGNETIC RESONANCE IMAGING
1SCREENING2023-08-01
10DMD-RTCV30110EXTRAVOLEXTRACELLULAR VOLUME

1.1

/s

1.1

1.1/sLEFT VENTRICULAR BASAL INFERIOR SEGMENTCARDIAC MAGNETIC RESONANCE IMAGING
1SCREENING2023-08-01