Late Gadolinium Enhancement (LGE) is an assessment made with CMR imaging that includesr gadolinium contrast administration. The test is done to assess for gadolinium contrast material accumulation in the tissue with increased extracellular space to determine both left and right ventricle fibrosis (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801263/). For LGE, the assessment relates to the timing of the reading showing whether or not the contrast is present or not at the specific time of the reading (would be determined by the protocol but typically is noted approximately 10 minutes after contrast injection). If the LGE is noted as present, more assessments may be done such as presence per segment and the percentage of presence per segment.
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- Is "CARDIAC WALL" okay for location?
- It is the only term in CT that fits. It seems wrong because technically if there is a mass within the heart, it would be seen on the CMR imaging.
- All the segments in the CT is for the LV, is it safe to assume the same segments for RV?
- Request SME review and update of text and values.
Note from standards discussion - Determined this would be an indicator test and there is an additional term LGE percentage. → is there anything different to do with this? |
The Procedures (PR) dataset is an interventions domain that represents diagnostic, preventive, and therapeutic activity. The PR dataset shows the cardiac magnetic resonance imaging with two different MR machines.
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Row 1: | Shows a cardiac MRI for subject 201. | Row 2: | Shows a cardiac MRI for subject 202 with a different MRI machine. |
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| Row | STUDYID | DOMAIN | USUBJID | SPDEVID | PRSEQ | PRREFID | PRLNKID | PRTRT | PRLOC | PRFAST | PRSTDTC |
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| 1 | DMD-LGE | PR | 201 | ABC001 | 1 | 12345678 | 04 | CARDIAC MAGNETIC RESONANCE IMAGING | CARDIAC WALL | Y | 2023-07-01T08:55:00 | | 2 | DMD-LGE | PR | 202 | ABC002 | 2 | 98765432 | 05 | CARDIAC MAGNETIC RESONANCE IMAGING | CARDIAC WALL | N | 2020-07-02T10:05:00 |
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The Cardiovascular System Findings (CV) dataset contains physiological and morphological findings related to the cardiovascular system, including the heart, blood vessels and lymphatic vessels. The findings from the CMR procedure for LGE are noted in this example.
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Rows 1-5: | Show the late gadolinium enhancement (LGE) is present and affecting 4 segments with corresponding percentage for each segment for subject 201. | Row 6: | Shows the late gadolinium enhancement (LGE) is absent for subject 202. |
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Row | STUDYID | DOMAIN | USUBJID | CVSEQ | CVLNKID | CVTESTCD | CVTEST | CVORRES | CVORRESU | CVSTRESC | CVSTRESN | CVSTRESU | CVLOC | CVMETHOD | VISITNUM | VISIT | CVDTC |
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| 1 | DMD-LGE | CV | 201 | 1 | 04 |
| LATE GADOLINIUM ENHANCEMENT | |
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| CARDIAC MAGNETIC RESONANCE IMAGING | 1 | SCREENING | 2023-07-01 | | 2 | DMD-LGE | CV | 201 | 2 | 04 |
| LATE GADOLINIUM ENHANCEMENT (# of segments) | |
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| CARDIAC MAGNETIC RESONANCE IMAGING | 1 | SCREENING | 2023-07-01 | | 3 | DMD-LGE | CV | 201 | 3 | 04 | LGEPER | LATE GADOLINIUM ENHANCEMENT PERCENTAGE | | % | | 20 | % | LEFT VENTRICULAR BASAL ANTERIOR SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING | 1 | SCREENING | 2023-07-01 | | 4 | DMD-LGE | CV | 201 | 4 | 04 | LGEPER | LATE GADOLINIUM ENHANCEMENT PERCENTAGE | | % | | 30 | % | LEFT VENTRICULAR BASAL ANTEROSEPTAL SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING | 1 | SCREENING | 2023-07-01 | | 5 | DMD-LGE | CV | 201 | 5 | 04 | LGEPER | LATE GADOLINIUM ENHANCEMENT PERCENTAGE | | % | | 45 | % | LEFT VENTRICULAR MID INFERIOR SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING | 1 | SCREENING | 2023-07-01 | | 5 | DMD-LGE | CV | 201 | 6 | 04 | LGEPER | LATE GADOLINIUM ENHANCEMENT PERCENTAGE | | % | | 50 | % | RIGHT VENTRICULAR MID INFERIOR SEGMENT | CARDIAC MAGNETIC RESONANCE IMAGING | 1 | SCREENING | 2023-07-01 | | 1 | DMD-LGE | CV | 202 | 1 | 05 |
| LATE GADOLINIUM ENHANCEMENT | |
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| CARDIAC MAGNETIC RESONANCE IMAGING | 1 | SCREENING | 2023-07-01 |
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The Procedure Agent (AG) dataset is an interventions domain that contains the agents administered to the subject as part of a procedure or assessment. The AG dataset shows the timing of the Gadolinium based contrast, GD-DOTA.
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Row | STUDYID | DOMAIN | USUBJID | AGSEQ | AGLNKID | AGTRT | AGCAT | AGDOSE | AGDOSU | AGDOSFRM | AGROUTE | AGSTDTC |
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1 | DMD-LGE | AG | 201 | 1 | 04 | Gd-DOTA | CONTRAST AGENT | 8 | mL | SOLUTION | INTRAVENOUS | 2023-07-01T08:45:00 | 1 | DMD-LGE | AG | 202 | 1 | 05 | Gd-DOTA | CONTRAST AGENT | 10 | mL | SOLUTION | INTRAVENOUS | 2023-07-05T09:55:00 |
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