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Clinical trials involving a tobacco product may include assessments of pattern of product use, extent of exposure to toxicants and biological effects, abuse potential and consumer perception of the product, as well as other physiological and subjective effects . This may include nicotine pharmacokinetics, questionnaires, and daily diaries to assess tobacco and nicotine use status, biomarkers of exposure as well as medical history, physical examination and other routine data. These studies types include abuse liability studies, in-laboratory clinical trials (subject uses the product once or a few times, but only in a laboratory setting), short-term clinical trials (<2 weeks of duration on a particular product), intermediate-term clinical trials (> 2 weeks and ≤ 12 months), or long-term clinical trials (>12 months), 

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