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Biomarkers of tobacco exposure are typically measured in blood (serum or plasma) and urine. Urine testing is usually recommended to detect chronic use because analytes are detectable for a longer period of time in urine than in serum or plasma. 

Biomarkers of exposure may be used to evaluated the pharmacokinetics of tobacco products. After the specific tobacco product is used, these biomarkers are measured serially to determine well-defined pharmacokinetic parameters ( e.g., AUC, TMX, T 1/2 ), the concentration level at the pre-specified timepoints would be represented in the PC/PK SDTM domains (Section 3.3.3.2 Pharmacokinetics Concentration and Parameters (PC, PP)). Otherwise, these biomarkers would be represented in the Laboratory Testing Results (LB) domain. 

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